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Human PBMC-derived killer cells are incubated with various target cancer cells, representing solid and hematologic malignancies. Target cell death can be measured using rapid and cost-effective methods, including flow cytometry, IFNg secretion, luminescence, and Calcein-Acetyoxymethyl release. interested in learning more about our capabilities? contact us to schedule a meeting ==> pharmaseed@pharmaseedltd.com visit our website ==> https://lnkd.in/d-zS3V26 #cro #preclinical #preclinicalresearch #invitro #immunotherapy #immunooncology

Are you interested in having a quick overview of approved targeted therapies and #CDx assays for non-small cell lung cancer (NSCLC) patients? If the answer is yes, keep reading! Did you know that there are: - 62 CDx approvals (all methodologies included) - based on 16 assays (out of which 4 are tissue- and 2 liquid biopsy NGS-based assays) and - they are manufactured by 9 providers only! On a leading position is #Roche (including Foundation Medicine) which holds 37 CDx approvals, followed by #LifeTechnologies (8 CDx's), #Qiagen (6), #GuardantHealth (4), #Agilent (Dako) (3), #Abbott (2), #PillarBiosciences (1) and #ExactSciences (Resolution Biosciences (1)).  This goes along with 24 molecularly matched therapies, of which, 3 are combo therapies. I also provide you with the list of new approvals/extensions that have occurred during Q1 2024. Let me know if this is useful (and shout if anything is missing!) ! Have a great Friday everyone! #molecularlymatchedtherapies #targetedtherapies #precisiononcology #CDx

Durable benefit from poly(ADP-ribose) polymerase inhibitors in metastatic prostate cancer in routine practice: biomarker associations and implications for optimal clinical next-generation sequencing testing

How can aligning cancer treatments with circadian rhythms improve outcomes? Ector et al. provide a high-throughput method [experimental and computational techniques] to optimize drug efficacy, paving the way for personalized medicine research. - - - Ector, C., Schmal, C., Didier, J. et al. Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping. Nat Commun 15, 7205 (2024). https://lnkd.in/dw_Nbcpn #Chronotherapy #CancerResearch #ComputationalBiomedicine - - -

Cell cycle analysis is crucial for investigating cancer therapeutics, especially to understand population heterogeneity and identify outliers with drug resistance. Livecyte combines label-free Quantitative Phase Imaging (QPI) with fluorescence to provide deep insights into cell-cycle changes. Analyse both at the population and single-cell levels to assess dry mass, growth, and time spent in each phase of the cycle. 🧬 Check out the video to see this in action 👇 #CancerResearch #CellBiology #Microscopy #DrugDiscovery #LifeSciences

Immunotherapy: Opportunities and advances Immunotherapies are at the cutting edge of therapeutics research, offering some of the most advanced treatments for cancer and other diseases.   This eBook, sponsored by Sino Biological, Inc., examines the latest innovations that are driving the market and overcoming the challenges associated with these treatments.   Download this exclusive eBook to learn more about:  - Recent developments in immunotherapy drug discovery - The risks and benefits of using immunotherapies to treat cancer - The potential of T-cell receptor (TCR) T cell therapies - Using AI and spatial biology to develop better immunotherapies   Access this eBook for FREE now https://lnkd.in/e3evyZ3n #Immunotherapy #DrugDiscovery #CellTherapy

We’re pleased to share 𝐏𝐫𝐞𝐜𝐢𝐬𝐢𝐨𝐧 𝐌𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐢𝐧 𝐋𝐮𝐧𝐠 𝐂𝐚𝐧𝐜𝐞𝐫: 𝐇𝐨𝐰 𝐂𝐨𝐦𝐩𝐫𝐞𝐡𝐞𝐧𝐬𝐢𝐯𝐞 𝐓𝐞𝐬𝐭𝐢𝐧𝐠 𝐎𝐩𝐭𝐢𝐦𝐢𝐳𝐞𝐬 𝐏𝐚𝐭𝐢𝐞𝐧𝐭 𝐎𝐮𝐭𝐜𝐨𝐦𝐞𝐬: https://lnkd.in/gu9En-em   Over the past two decades, targeted therapies and immunotherapy have revolutionized the treatment of metastatic non-small cell lung cancer (#NSCLC). Comprehensive #biomarker testing, including next-generation sequencing (#NGS), is essential but underutilized. Experts recommend broad molecular profiling to guide treatment and improve outcomes.   For optimized testing strategies, contact us at 866.776.5907 or client.services@neogenomics.com.

Cells cleansing themselves by removing pathogens, unfolded proteins, and malfunctioning organelles, is a process called autophagy. This is an essential process for cell stability and balance which malfunctions in cancer cells. The authors synthesize two highly fluorescent compounds, called Boron Dipyrromethenes (BODIPYS), to target lysosomes and lipid droplets in cancer cells. Upon irradiation with light, they generate molecules called Reactive Oxygen Species that trigger cancer cell death by inducing autophagy. The use of these BODIPYs, as markers in cancer diagnostics, and in therapeutics using light (Photodynamic therapy), is an effective alternative to chemotherapy or invasive treatments for cancer, which cause side effects. Read the paper here:https://lnkd.in/gs6J3ytZ  #science #scicomm #research #phd #IITGNResearchSnips  #IITGNResearchers #IIT #IITGNResearchSnips #Research #IITGNResearchers Jaydeepsinh Chavda Iti Gupta

Consider combining nanotechnology with immunotherapy for enhanced lung cancer treatment. By utilizing nanoparticles loaded with anticancer drugs that target multiple proteins on cancer cells, this dual approach can boost the immune system's ability to combat tumors and minimize side effects. This innovative strategy shows promise in preclinical testing, offering hope for more effective and personalized cancer care. #Nanomedicine #Immunotherapy #CancerResearch #PrecisionMedicine #InnovativeTherapies BioMedHack.com is your leading source for the latest news, breakthroughs, and insights in medicine, biohacking, and alternative medicine. Our mission is to help you live healthier and longer by bringing you cutting-edge information and expert advice. Follow us on Facebook, Instagram, and X. Read more about this post here: https://lnkd.in/en7ysBub

Identifying extracellular vesicle lncRNAs as circulating cancer biomarkers: in this review article, Panagiotis Papoutsoglou and Antonin Morillon at Institut Curie aimed to advance understanding of the functional roles of extracellular vesicles and their non-coding RNA cargo in cancer progression, emphasising the potential of EV RNA as novel diagnostic and prognostic biomarkers https://lnkd.in/g9mSntnQ The study also addresses recent technological advances and challenges in identifying EV RNA, assessing its integrity, and preserving its functionality for clinical applications. #extracellularvesicles #exosomes #biomarkers #tumorgenesis #Vesiculab