🥳 Proud to share with you my latest research article as a preprint now online on #bioRxiv! "Dopamine reveals adaptive learning of action representation"
https://lnkd.in/eW6y2YHQ
🎯 In this research article, I delve into the theories of decision making, reinforcement learning and cognitive representations, through experiments on mice behavior and dopamine measures.
Like Pavlov’s dog associating a bell 🔔 with food 🍖 , humans and other animals continuously try to infer associations between predictive events and outcomes (good ✅ or bad ❌ ). Through experience, our brain 🧠 learns to assign predictive values to environmental items, building subjective preferences and updating our mental models of the world 🤔. This process, called reinforcement learning, involves computing a "Reward Prediction Error" (RPE, i.e. a comparison between what was expected and what was really obtained), signaled by the neurotransmitter dopamine, to adjust behavior.
Leveraging a decision game where mice 🐭 have to solve different reward delivery rules to gain rewards 🏁, I discuss in this paper how different items or features (e.g., a bell ring or a red light) can hold different predictive values depending on context, and how analyzing dopamine can reveal which features our brain uses to build expectations and predict outcomes. Moreover, I show that when changing context (e.g., from rule A to rule B), dopamine signal also reveals a change in the internal model of the world (e.g. now, it is the red light that matters to predict a reward and guide decision).
This work has been conducted in #ESPCI #BrainPlasticityLab #PSL and #SorbonneUniversités, with funding from the #FondationRechercheMédicale. On top of years of experiments and several presentations 👨🏫 in world-class congresses (#Dopamine2022, #NeuroFrance2022, #FENS2024), it also involves a great deal of data analysis 📈, statistics and AI to extract such exciting results! I thank my supervisor #PhilippeFaure and all my colleagues who were of great support to bring this project that far! 🚀
If you want to go deeper, please feel free to dive into the texts and figures, or message me for more details.