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Posterior Composite Injection Over-Molding Following Root Canal Treatment Using 3M™ Filtek™ Bulk Fill Flowable Restorative. #Solvers #Solventum #Bioclear #Filtek

Posterior Composite Injection Over-Molding Following Root Canal Treatment Using 3M™ Filtek™ Bulk Fill Flowable Restorative. #Solvers #Solventum #Bioclear #Filtek

Black triangles are a growing concern for patients, but not every clinician knows how to treat them. Learn how one versatile, predictable technique could help you close the gaps, improve patient acceptance and satisfaction and build your practice. #Filtek #Bioclear #LifeAtSolventum

Thrilled to share my #RSCPoster for online RSC Poster Conference 2024 on LinkedIn platform entitled as "Ionic-molecular organocatalysis enabling allylic amination reactions". We report here an "ionic-molecular" organocatalysis as a viable substitute for the metal-dependent allylic amination reactions. Mechanistic highlights supported by 31P nuclear magnetic resonance, high-resolution mass spectrometry, and experimental studies highlight the prior covalent ligation of allylic alcohols via ionic catalysis coupled with nucleophilic phosphine catalysis, yielding allylamines via the SN2’ -SN2’ (or SN1-SN2’) pathway. Implementation of this ionic-molecular catalysis in heterocyclic functionalizations (N-allylation) with excellent chemo- (N vs. O), regio- (linear vs. branch), and stereo-selectivity (E vs. Z) and active pharmaceutical ingredient (flunarizine, cinnarizine, and naftifine) synthesis has been successfully demonstrated. #RSCPoster #RSCCat #RSCOrg

Solid-State Nuclear Magnetic Resonance Spectroscopy (ssNMR) focuses on issues directly related to solid-state properties of materials. The application of ssNMR has grown to a point where a general chapter is warranted. USP is now inviting industry experts to discuss fundamental principles and practical applications of ssNMR. Interested stakeholders can join this open forum👇 #usp #ssnmr #scienceandresearch

-> Read Blog: Utilizing advanced Nuclear Magnetic Resonance (NMR) technology - our latest research provides startling insights into MDMA content variability in street ecstasy tablets. This NMR-driven analytical accuracy sets a new standard in spectroscopy methods for #DrugAnalysis, significantly impacting harm reduction and public safety strategies. #Nanalysis #benchtopNMR #NMR #NMRchat https://lnkd.in/dC4E3NPu

Biochemical Befense Market 2024 Development Status and Future Statistics by 2031 As of my last update in January 2022, the "Biochemical Defense" market refers to the industry involved in #producing and #supplying products and #technologies aimed at defending against biochemical threats. This includes defense against #chemical, #biological, #radiological, and #nuclear (CBRN) threats. Biodefense: This includes the development and deployment of #vaccines, #antidotes, and #medicalcountermeasures against biological threats such as #anthrax, #smallpox, and other infectious agents. Chemical Defense: This involves technologies and products to detect, protect against, and respond to chemical threats such as nerve agents, toxic industrial chemicals, and other hazardous substances. Radiological and Nuclear Defense: This sector focuses on detection, protection, and response mechanisms against radiological and nuclear threats, including dirty bombs and nuclear accidents. 𝐑𝐞𝐪𝐮𝐞𝐬𝐭 𝐟𝐨𝐫 𝐒𝐚𝐦𝐩𝐥𝐞 𝐏𝐃𝐅: https://lnkd.in/gspdUUQ4 Biochemical Befense Market By Type: Anthrax Smallpox Botulism Radiation/Nuclear Other Biochemical Befense Market By Application: National Defense Military Companies Profiles in the Report: Emergent BioSolutions, Hytest, GSK, Sanofi, PharmAthene US Corp, Bavarian Nordic, SIGA Technologies, Arbutus Biopharma Corporation BIOPHARMA, DynPort Vaccine Company LLC, A GDIT Company , XOMA Corporation, Ichor Medical Systems, Aeolus Pharmaceuticals, Achaogen, Elusys Therapeutics, Inc. , Dynavax Technologies, Cleveland BioLabs, Soligenix, Inc., Alnylam Pharmaceuticals #𝒎𝒂𝒓𝒌𝒆𝒕𝒔𝒊𝒛𝒆 #𝒎𝒂𝒓𝒌𝒆𝒕𝒕𝒓𝒆𝒏𝒅𝒔 #𝒎𝒂𝒓𝒌𝒆𝒕𝒇𝒐𝒓𝒆𝒄𝒂𝒔𝒕 #𝒎𝒂𝒓𝒌𝒆𝒕𝒂𝒏𝒂𝒍𝒚𝒔𝒊𝒔, #producing ,#supplying #technologies , #chemical, #biological, #radiological, #nuclear, #vaccines, #antidotes, #medicalcountermeasures #anthrax, #smallpox.

A new paper released, titled "Is the Functional Response of a Receptor Determined by the Thermodynamics of Ligand Binding?" explores the Absolute-Binding Free Energy Perturbation (ABFEP) method's utility in predicting ligand efficacy across a broad spectrum of target-ligand pairs, chiefly focusing on G protein-coupled receptors (GPCRs) and a nuclear receptor. The methodology hinges on selecting ligands with available functional data, encompassing both congeneric series and diverse molecular frameworks. Researchers employed Molecular Dynamics (MD) simulations to generate template conformational ensembles reflecting both the active and inactive states of receptors. Notable elements of their approach include k-means clustering of Cα atom distances within the binding pocket, the creation of initial structures, and the application of restraints for Free Energy Perturbation (FEP) calculations. They employed a flat-bottom harmonic potential to restrain the receptor's Cα-atoms to refine their predictions. The results showed an impressive initial prediction accuracy of 93% across the examined target-ligand pairs using ABFEP, which was further enhanced to 98% by fine-tuning the classification thresholds for each receptor. This high predictive success is attributed to the method's ability to calculate the differential binding free energies between ligand interactions with the active and inactive receptor states. The research underscores that a receptor's functional response is dictated by the equilibrium between its conformational states rather than the binding affinity to a single state. This study highlights the critical role of accurately defining restraints and ligand positioning within the receptor's binding sites to achieve reliable predictions. https://lnkd.in/gFs7TkMz

Exciting news! Katrina Skerratt-Love PhD BEng(Hons) AFHEA MIMMM, Owen McGann, and Chris Holcroft from Glass Technology Services will be at stall C20 of the #MRE2024 tomorrow and Wednesday. Swing by and say hello to learn more about how #GTS can help you with all your glass needs in the #glass #biomedical #nuclear #space #energy #environment #food #drinks #photonics #optics #cosmetics #pharmaceutical industries. Check out our promo video and contact us now at enquires@glass-ts.com or sales@glass-ts.com. Trust the experts at #GTS for all your glass needs.

📢 Tiny Molecular Differences in Vaccines: A Game Changer 📢 In the world of vaccine manufacturing, even minuscule molecular variations matter. According to a recent article, small differences in the composition of polysaccharides, a vital component of some vaccines, can significantly impact their effectiveness. To tackle this issue, scientists are using advanced forms of nuclear magnetic resonance NMR spectroscopy to analyze the atomic structure of polysaccharides. This information can help ensure that vaccines meet regulatory requirements for safety and effectiveness. So, attention to detail is crucial in vaccine production. 💉❗️ #BioprocessUpdates #vaccinevariations #molecularanalysis #polysaccharides #effectiveness #safety #regulatoryrequirements #NMRspectroscopy #atomicstructure #vaccineproduction #attentiontodetail #vitalcomponent #scientificresearch #vaccinesafety #vaccineeffectiveness #nanoscaleanalysis ▷ Read the full article here: 📎 https://lnkd.in/dQCuXsWq