Sudarshan Shetty’s Post

🚀 Featured Publication - "Gut Microbiota Interactions in Multiple Sclerosis: The Role of SCFA-Producing Bacteria and Dietary Fiber" 👩🔬 First Author: Lucinda Toppen 👨🔬 Last Author: David Kleinschmidt 🗞 Full Publication: https://mtbln.co/gfdg1x   Today’s featured publication sheds new light on how gut microbiome composition, particularly Short Chain Fatty Acid (SCFA)-producing bacteria, may influence autoimmune conditions like multiple sclerosis (MS). Using an experimental MS model, the study shows that colonization by certain gut bacteria, such as L. reuteri, can significantly reshape the gut microbiome, leading to a reduction in beneficial SCFA-producing species—crucial contributors to anti-inflammatory responses in the body. What’s interesting? The research demonstrates that restoring SCFA levels in MS may not only depend on dietary fiber but may also require targeted modulation of the microbiome itself. Findings like these broaden our biological understanding and advance our efforts to unravel the complexities of this multifaceted autoimmune disease. #Metabolomics #MicrobiomeResearch #AutoimmuneDisease #MultipleSclerosis #GutBrainAxis #Microbiota #ShortChainFattyAcids

Very Important study shows that Fecal #microbial_load is a major determinant / confounder in #microbiome #studies, highlighting its importance for understanding microbiome variation in #health and disease. [Human/Mouse] [ML Analysis] NOTES: - The sequencing approaches determine the relative abundances of taxa and genes but do not provide information on their absolute abundances. - Microbial load is the major determinant of gut microbiome variation and is associated with numerous host factors, including #age, #diet, and #medication. - For several diseases, changes in microbial load, rather than the disease condition itself, more strongly explained alterations in patients’ gut #microbiome. - Adjusting for this effect substantially reduced the statistical significance of the majority of disease-associated species. #mbNotes: - Wondering why this very important factor is not properly taken into account.  Of course the amount of metabolites produced depends partly on the absolute volume of available microbiota ! The same problem may also apply to the #metabolites? - A STANDARD MICROBIOTA / METABOLITE LOAD INDEX !? Ref.: https://lnkd.in/epgxqYQD

[ #machinelearning #microbiome #disease ] ⛑️ HELP ! MACHINE LEARNING EXPERT NEEDED ! (and metagenomics specialists too)   💡 A few days ago, I posted about this revolutionary article published in Cell ( Linkedin : https://lnkd.in/gDPtxwMH , Free article in Cell : https://lnkd.in/gQ7xw6g8 ). This article described a collective work 🔬 led by Michael Kuhn and Peer Bork, about #microbial load as the major determinant of #gut #microbiome variation and its association with numerous host factors. The authors “further found that for several diseases, changes in microbial load, rather than the #disease condition itself, more strongly explained alterations in patients’ gut microbiome”. What caught my attention 👀 : 📌 Machine learning model capable of robustly predicting microbial load without requiring additional wet lab assays 📌 Predicted microbial loads are significantly associated with various host factors: #diet (#omnivore vs #vegetarian vs #vegan), high vs low-income countries, frequency of defecation, sex, lifestyle, and more important to me in regard to my #pharmacomicrobiomics interests : #diseases and #medication 📌Predicted microbial loads gradually recovered after antibiotics treatment (90-180 days) 📌 Majority of diseases (14/26) were significantly associated with the predicted microbial load : #Crohn’s disease, #ulcerative #colitis, #liver #cirrhosis C. difficile infection, #HIV (negative), #multipleSclerosis , #colorectal #cancer, #T2D , #Parkinson ‘s disease , #hypertension (positive) 📌Several bacterial species either lost or gained significance after adjustment, including some Clostridium, Bacteroides, Eubacterium, Ruminococcus species, Faecalibacterium prausnitzii . This was highlighted in diseases such as #CRC and #MS 🚀 In summary, these results might emphasize the need for analyses to take microbial load into account, which is of MAJOR IMPORTANCE. 🖐 YOUR OPINION (AND VALIDATION) NEEDED : - I would greatly appreciate your comments (I have the feeling most people don’t care about microbiome load) - Moreover, I am not a specialist in #machinelearning models. The whole results are based on this. Could some experts shed light about the freely available machine-learning model ? This would be so important for the community.   Many thanks in advance.   #microbiota #machinelearning #ai .

🌿Metabolite of the month: 3-Indoleacetic Acid (3-IAA) 🌿 Ever wondered how a compound can bridge plant growth and human health? Meet 3-IAA, a fascinating metabolite with a history stretching from its first synthesis in 1925 to its recent identification as a key player in the AhR pathway in 2020. Initially celebrated for its role in plant biology, 3-IAA has revealed its broader significance as a microbial metabolite of tryptophan in mammals, impacting immune function, inflammation, and metabolic health. Its exploration has been propelled by omics technologies, highlighting its therapeutic potential for cancer and autoimmune diseases. The synthesis of 3-IAA from dietary tryptophan underscores the intricate dance between our diet, microbiome, and overall health. Present in various bodily fluids, 3-IAA's relationship with the gut microbiota showcases its potential as a disease biomarker, thanks to metabolomic insights. Read more about the multifaceted world of 3-IAA, a metabolite that exemplifies the interconnectedness of life and its potential to unlock new avenues in health and disease management: https://zurl.co/avB8 #metabolomics #loveyourmetabolites

Lars Vliex Ellen Blaak John Penders Tuesday 3 December 2024 16.00 hrs. Lars Vliex will defend his PhD thesis on: “THE GUT MICROBIOME AND METABOLIC HEALTH IN HUMANS Individualised impact of antibiotic and prebiotic use“ Summary: Around the world, the rate of antibiotic prescription is high, and this comes with several downsides. As antibiotics do not only work against pathogenic bacteria, ingestion of these drugs disturbs beneficial bacteria of the gut microbiome as well. The gut microbiome plays an important role in regulating host metabolic health, and disruptions in gut microbial composition and function lead to detrimental health effects in the host. It is therefore important to develop strategies that limit antibiotic-induced disruption of the gut microbiome. One interesting strategy would be through the intake of prebiotics, which act as food for beneficial bacteria in the gut. Results from this thesis show that prebiotic intake after antibiotic use improved the recovery of the gut microbiome in the short term in adults with overweight or obesity. In addition, this thesis elucidated determinants of the individualised response to antibiotic and prebiotic use.    Supervisors: Prof. dr. Ellen E. Blaak, Maastricht University. Prof. dr. John Penders, Maastricht University Watch the livestream of Lars Vliex https://lnkd.in/eyTqhMQj #NUTRIM #nutrimresearchinstitute #nutrimdefence #nutrimphd #nutrimresearch #maastrichtuniversity #mumc+ #gutmicrobiome #metabolichealth #antibiotics #prebiotics

APC researchers Prof Noel Caplice, University College Cork and Prof Catherine Stanton Teagasc have published a new paper showing that gut inflammation can lead to heart damage - out now in the peer reviewed Journal of the American College of Cardiology: Basic to Translational Science. This study was a collaboration between Tate & Lyle and APC Microbiome Ireland, a Research Ireland centre at University College Cork and Teagasc (the Irish Agriculture and Food Development Authority). It’s the first time a synbiotic combination has been used to treat heart disease related to obesity and high blood pressure, showing results as effective as some of the best cardiac drugs. Read more: https://bit.ly/3D6IGW9 #GutHealth #HeartHealth #microbiome #Synbiotics #Probiotics #Prebiotics #Research #Nutrition

5G Alters Your Microbiome Scientific Reports February 12, 2024; 14, Article number 3571 Lastly, a February 2024 study by Wang et al. examined the impact of 5G RFR on the fecal microbiome and metabolome profiles in mice. The results indicated that the mice exposed to RFR experienced significant alterations in their intestinal microbial compositions, characterized by a decrease in microbial diversity and shifts in the microbial community distribution. Through metabolomics profiling, the researchers identified 258 metabolites that were significantly differentially abundant in the mice exposed to RF fields compared to controls, which suggests it can have a profound impact on metabolic processes. The authors concluded that exposure to 4.9 GHz RFR can cause intestinal microbiota dysbiosis in mice and hypothesized that the observed imbalances in gut microbiota and metabolism might be linked to depression-like behaviors in mice seen in so many studies. The imbalance in the metabolic profile may also be associated with changes in immune regulation or inflammation. We know we need a diverse and equilibrated microbiome to stay healthy, so this is clearly of concern to me… #lifestylemedicine #preventivemedicine #stayhealthy #biohacking #EMFprotection #microbiome

Probiotics, prebiotics, synbiotics and other microbiome-based innovative therapeutics to mitigate obesity and enhance longevity via the gut-brain axis https://lnkd.in/drkkbnmE Microbiome Research Reports. OAE Publishing Inc. Jacqueline Boyajian, Paromita Islam, Ahmed Abosalha, Sabrina Schaly, Rahul Thareja, Amal Kassab, Karan Arora, CPI, Madison Santos, Cedrique Shum-Tim, Dr. Satya Prakash (McGill University) This review discusses the interrelationship between obesity and aging, with a particular emphasis on the gut microbiome, and presents biotics as novel therapeutic agents for obesity, aging and related disease states. #microbiome #obesity #microbiomebasedtherapies #gutbrainaxis #aging #probiotics #prebiotics

You are what you eat! 🧬✨ #Epigenetics reveals how your diet, lifestyle, and environment can impact your health. Discover how the DNAge test can help you personalize your molecular nutrition plan—for you (and your furry friends!🐾) ! MyDNAge (Epimorphy LLC) #aging #diet #nutrition #lifestyle #DNA methylation

Huge publication in Nature Magazine by Calico Life Sciences disentangling the contribution of genetic diversity to dietary interventions! Treasure chest of results - like the observation that the biggest determinant of lifespan extension are immune- but not metabolism-related. Calico just keeps on delivering research of the highest tier. https://lnkd.in/gn8mE9Mc