Surface Measurement Systems’ Post

In the ever-evolving landscape of pharmaceuticals, there's a crucial yet often overlooked aspect that demands recognition: peptide API production. Despite the spotlight often shining on #drugformulations, the real innovation & expertise lie in the complexities of peptide API manufacturing. Peptide APIs are the unsung heroes of pharmaceutical manufacturing in past or present or in future, requiring precision & expertise often overlooked. It's crucial to dispel misconceptions and understand the complexities involved in peptide API production. Unlike common formulations, creating #sterileinjectables like peptides involves rigorous chemistry, purification techniques & stringent quality control. The real challenge lies in the #peptideAPI, not #APIsector, not #formulation, where steps like solid-phase peptide synthesis (#SPPS) & Chromography Purification (RPHPLC) & Sublimation technic demand meticulous attention & profound #AdvancedChemistry & #chemicalengineering #knowledge. While formulation is key for stability & delivery, true innovation & investment shine during #PeptideAPIProduction. Despite the significance of peptide API work, there is a misdirected focus on formulation, undermining the pivotal role of API quality in the final product's effectiveness & safety. Recognizing the intricacies of peptide manufacturing is crucial as the industry progresses. It's time to acknowledge the expertise and innovation driving the production of these life-changing APIs. #Pharmaceuticals #API #PeptideManufacturing #Innovation #QualityControl #HappyFreedomDay for investments(#Time, #Cost, #Process) into #PeptideAPI never ever than before to get more than 10 times Return (#Sustainability, #Cost, #Health).

🔎🔎 Solubility of API in pharmaceutical solutions 🔸 Preformulation solubility studies usually include: • determinations of pKa. • temperature dependence. • pH solubility profile. • solubility products. • possible solubilization mechanisms. • rate of dissolution. 🔸 Factors effecting solubility: • pH • temperature • ionic strength • buffer concentrations. 🔎 For pH: - for weakly acid ⏩ increasing pH of solution Increasing solubility of API. - for weakly bases ⏩ increasing pH of solution decreasing solubility of API. ⚠️ It must be considerable for the STABILITY of the pharmaceutical solution: - the pH rate profile of API. - unionized/inonized ratio of API. - The possibility of acid-base catalysis of API in aqeous acidic or basic solution. 🔎 For ionic strength of API & interactions between two ionic moieties in same solutions: if your drug is ionic and reacts with one of the ionic additives of similar charges (e.g. the buffer components) make sure to keep the concentration of electrolytes in the formula as low as possible to slow down the degradation rate of the drug and visca varse with the different charges. 🔎 Common solubilization methods includes: • Co-solvency • Micronization • Using complexing agent • eutectic mixures by loading API on a Carrier. #pharmaceutical #solution #formulation #sterile #liquid

Today’s active pharmaceutical ingredients (APIs) are increasingly complex in structure and challenging for isolation. Effective API particle engineering is playing a critical role in meeting the demands for drug substance and drug product development. Although crystallization process is desired and commonly used as final isolation step for API production, there are many practical challenges from early process development to process scale-up and implementation in the plant. Some of the challenges are inherently related to the molecular structure and/or API crystal properties, such as high solvation propensity, low chemical stability, high oiling tendency, impurity/API structure similarity, etc.. Some are related to the inherent scale-up issues of batch processing, with drastic changes in mass, heat, and momentum transfers in large batch crystallizers. At AIChE annual conference next week, I'll present in the “495 Continuous Crystallization Processes” session and share case studies when continuous crystallization offers robust processing solutions to challenging APIs that are otherwise hard to isolate and produce at large scale. I look forward to fruitful discussions and further learning. #AIChE #crystallization #continuouscrystallization #particleengineering #API #isolation

"Ultraselective Macrocycle Membranes for Pharmaceutical Ingredients Separation in Organic Solvents" 📚 Summary 👨🏫 A recent study from Nature Communications introduces a breakthrough in membrane technology. Those, made from fully crosslinked crown ethers, show remarkable improvements in selectivity and solvent permeance, achieving up to 90% higher selectivity than existing commercial membranes. Why It’s Interesting 💡 This approach offers significant advancements for the pharma industry. The ability to efficiently separate and retain active pharmaceutical ingredients (APIs) with molecular weights around 800 g/mol could revolutionize how we process and purify sensitive compounds ! In NUVISAN The Science CRO, we have expertise in API synthesis, separation and characterization ? DM me or comment "API" to get more informations about our capabilities ! #Chemistry #Pharmaceuticals #MembraneTechnology #DrugDevelopment #SeparationProcesses #Nanofiltration #NatureCommunications #Innovation

🔬 RP vs NP Chromatography: What Sets Them Apart? 🌟 High-Performance Liquid Chromatography (HPLC) offers two distinct methods—Normal Phase (NP) and Reverse Phase (RP) Chromatography—that can significantly impact your analytical outcomes. Whether you’re working in pharmaceuticals, environmental analysis, or quality control, understanding the differences between these techniques is key to achieving accurate results. 🧪 RP-HPLC (Reverse Phase) is a go-to technique for separating non-polar to moderately polar compounds. With its non-polar stationary phase, typically C18-bonded silica, it excels in analyzing pharmaceuticals, proteins, and other complex mixtures, providing high resolution and sensitivity. ⚗ NP-HPLC (Normal Phase) is tailored for very polar compounds, using a polar stationary phase like silica. It’s particularly effective for chiral separations, lipid analysis, and small polar molecules that may not perform well under RP conditions. ✨ Key Differences: Stationary Phases: RP-HPLC uses a non-polar stationary phase, while NP-HPLC relies on a polar one. Mobile Phases: RP-HPLC typically involves polar solvents mixed with water (e.g., acetonitrile), whereas NP-HPLC utilizes non-polar solvents like hexane. Separation Mechanisms: RP-HPLC retains non-polar compounds longer, making it ideal for hydrophobic substances, while NP-HPLC retains polar compounds longer, focusing on polarity-based separations. 💡 When to Use Each Method: RP-HPLC: Ideal for pharmaceuticals, proteins, and complex mixtures where non-polar compounds dominate. NP-HPLC: Best for polar compounds, chiral separations, and applications involving lipids. 🌟 Advantages and Disadvantages: RP-HPLC: Broadly applicable with high sensitivity but can be costly and complex to optimize. NP-HPLC: Excels with polar compounds and chiral separations but may require expensive columns and the use of non-aqueous solvents. Choosing the right method not only enhances your analytical precision but also ensures effective separation and accurate quantification. ✨ Explore the full comparison in our latest article 👇 https://lnkd.in/dg2FkGBp #GMPInsiders #Chromatography #RPvsNP #ReversePhaseChromatography #NormalPhaseChromatography #HPLC #Pharmaceuticals #AnalyticalChemistry #QualityControl #LabTech

Jet Milling is a cutting-edge technology that has revolutionized the way pharmaceutical particle size reduction is achieved. In this post, we'll delve into five fundamental ways in which Jet Milling enhances the process, leading to more precise and effective results.🔬💊 #ParticleSize

The Science of Lyophilization in the Pharmaceutical Industry 🌡️👩🔬 In the fast-paced world of pharmaceuticals, where stability and longevity are paramount, lyophilization has become an indispensable technique. But what is lyophilization? Lyophilization, also known as freeze drying, is one of the most critical yet often overlooked technologies in the pharmaceutical industry. By carefully controlling the removal of water from a product through freezing and sublimation, this process ensures that medications remain effective and safe over extended periods, even in challenging storage conditions. Without lyophilization, many of the drugs and biologics we rely on today would be far less stable and more prone to degradation.   Here’s a closer look at the steps involved:   1. Freezing: The product is cooled below its eutectic point, ensuring that all the water forms solid ice crystals. 2. Primary Drying (Sublimation): Under low pressure, the ice converts directly into vapor without passing through the liquid phase. This step removes the bulk of the water. 3. Secondary Drying (Desorption): Any remaining water molecules are removed, often requiring higher temperatures to break the bonds between water and the product.   Join us as we unpack the intricacies of this fascinating technology and discuss its profound impact on the pharmaceutical industry, and explore the meticulous science behind lyophilization, including the critical parameters that must be carefully controlled; such as temperature, vacuum pressure, and the use of cryoprotectants.   Follow the link to the article here 👉 https://lnkd.in/dYzS9K7P #lyophilization #freezedrying #pharmaceuticals

𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗟𝗶𝗾𝘂𝗶𝘀𝗼𝗹𝗶𝗱 𝗣𝗲𝗹𝗹𝗲𝘁𝘀 𝗧𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 𝗳𝗼𝗿 𝗜𝗺𝗽𝗿𝗼𝘃𝗶𝗻𝗴 𝗗𝗶𝘀𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗼𝗳 𝗣𝗼𝘀𝗮𝗰𝗼𝗻𝗮𝘇𝗼𝗹𝗲: 𝗔 𝗗𝗼𝗘 𝗕𝗮𝘀𝗲𝗱 𝗣𝗿𝗼𝗰𝗲𝘀𝘀 𝗢𝗽𝘁𝗶𝗺𝗶𝘇𝗮𝘁𝗶𝗼𝗻 The present investigation was aimed to formulate and evaluate liquisolid pellets of PSZ for improving its dissolution. Liquisolid pellets were prepared using #Transcutol® HP, #Neusilin® US2, and #Aerosil® 200 as non-volatile liquid, carrier, and coating materials respectively. A 32 full factorial design having excipient ratio (R) and spheronization speed as independent variables and the cumulative amount of drug dissolved at 135 min and 165 min as dependent variables were used for the process optimization. #pharmaceutical #excipients Gattefossé Pharmaceuticals Fuji Chemical Industries USA, Inc Evonik Health Care https://lnkd.in/eGncM2qH

Did you know that the amylase enzyme revolutionized the pharmaceutical industry? Amylase is a natural enzyme that can help improve the efficiency of making tablets  By reducing the friction between molecules,  Amylase can make tablet filling machines run more smoothly and efficiently. Use of amylase can lead to: ⏺ Reduce filling time by up to 50% ⏺ Reduce the number of breakdowns by up to 75% ⏺ Reducing the amount of wasted materials from medicines and capsules by up to 90%, and all of this is the result of getting rid of starchy impurities with only one solution, which is the amylase enzyme from PhytoBiochem. For more information, contact us +201024093532 #phytobiochem #maltodextrin #supplements #medicines #manufacturing #industry #production #increasing #productivity #makers