Tess Sergio, DVM, MSc, MBA’s Post

I’ve just attended a very interesting seminar on reviewers’ bias for animal models. The seminar was promoted by Johns Hopkins Center for Alternatives to Animal Testing (CAAT). The speaker, Catherine E. Krebs, presented data indicating that the bias is real and provided interesting suggestions on how to handle it. This might be of use for scientists relying on the latest in vitro models, organoids, spheroids, human-on-chip who might have at some point in their career experienced this bias from manuscript and grant reviewers requesting additional, unnecessary, in vivo experiments to corroborate their findings. More information can be found at: AnimalMethodsBias.org ckrebs@pcrm.org

The #mdcBerlin is getting on #BOARD24! "𝗕𝗢𝗔𝗥𝗗" stands for 𝗕e 𝗢pen about 𝗔nimal 𝗥esearch 𝗗ay. This global social media campaign is organized by the European Animal Research Association (EARA) and supported by the wider biomedical community, both public and private. Below, you will find several #research findings from some of our labs that would not have been possible without animals. Transparency about #AnimalResearch is a fundamental value for us, as it is for #EARA, all of its members, and participants of today's campaign. Get on #BOARD24!   Learn more about the Max Delbrück Center's open and transparent communication regarding animal research: https://lnkd.in/eci5ijT3 𝗔 𝗻𝗲𝘄 𝗰𝗵𝗮𝗻𝗻𝗲𝗹 𝗳𝗼𝗿 𝘁𝗼𝘂𝗰𝗵 | Every hug requires touch perception. To understand its molecular basis, a team led by MDC-Berlin scientist Gary Lewin used mice – and discovered an ion channel associated with touch that is also a possible target for #PainTherapy. More information 👉 https://lnkd.in/dVWtHu9i 𝗚𝗲𝗻𝗲 𝗲𝗱𝗶𝘁𝗶𝗻𝗴 𝗽𝗿𝗲𝗰𝗶𝘀𝗲𝗹𝘆 𝗿𝗲𝗽𝗮𝗶𝗿𝘀 𝗶𝗺𝗺𝘂𝗻𝗲 𝗰𝗲𝗹𝗹𝘀 | Imagine you could help infants with a rare #ImmuneDisease by repairing a faulty gene in their T cells. The gene scissors #CRISPR-Cas9 would need to be precise –and MDC-Berlin's Klaus Rajewsky has shown that it’s possible in mice. More information 👉 https://lnkd.in/eQ9--zDD 𝗛𝗼𝘄 𝘀𝗸𝗮𝘁𝗲𝘀 𝗹𝗲𝗮𝗿𝗻𝗲𝗱 𝘁𝗼 𝗳𝗹𝘆 𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝘄𝗮𝘁𝗲𝗿 | A new way of thinking about how genomes evolve: Instead of looking at variations in the #DNA sequence, former MDC-Berlin scientist Darío Lupiáñez focuses on the 3D structures the DNA is folding into. He discovered how skates learned to fly through water. More information 👉 https://lnkd.in/erEAMuGq 𝗛𝗲𝗮𝗿𝘁 𝗿𝗲𝗽𝗮𝗶𝗿 𝘃𝗶𝗮 𝗻𝗲𝘂𝗿𝗼𝗶𝗺𝗺𝘂𝗻𝗲 𝗰𝗿𝗼𝘀𝘀𝘁𝗮𝗹𝗸 | Unlike humans, #zebrafish can regenerate their hearts after injury. They owe this ability to crosstalk between their autonomous nervous and immune systems, a team of MDC-Berlin group leader Suphansa Sawamiphak discovered studying zebrafish larvae. More information 👉 https://lnkd.in/e5dbe-H7

#ResearchNews from Université de Montréal: #StemCell -derived retinal tissue transplants have successfully restored vision in animal models of #Photoreceptor degeneration. Read the full study in The Company of Biologists: https://bit.ly/3CXBE67 #VisionResearch #ResearchNews #NationalEyeInstitute #StemCellResearch #StemCells

Great talk by #CAPKR PhD researcher Alex Foster-Powell on Leveraging machine learning to evaluate animal models of Alzheimer’s. 💡highlights include an introduction of workflow to evaluate the transalatability of various animal models for Alzheimer’s disease and validated the workflow with drug treated mice The University of Manchester #CAPKR #Alzheimers #Alzheimerresearch #animalmodels #machinelearning

How many of my connections are routinely performing immunohistochemistry (IHC) or other applications where you need to block background signal with animal sera. - Background staining may become an issue with the use of secondary antibodies. - A common cause of background staining is improper blocking of the tissues or cells. - Blocking should not be carried out using serum from the same host species as the primary antibody as this will result in higher background. Life Science Group Ltd. provides a wide range of sera suitable for use in blocking applications. https://lnkd.in/dcd6BBTF

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Proud to have completed the workshop on "Laboratory Techniques & Guide for Animal Research: Models Designing, Handling, and Dissection" at the 39th Annual Conference of the Faculty of Medicine, Tanta University. Excited to apply these new skills in my research! #MedicalResearch

Learn how to quantify bioluminescent cells in your animal models! Read the full protocol: https://ow.ly/rOcI50T2keQ #invivo #preclinical #imaging #research #immunooncology #immunotherapies #optical #smallanimalimaging #invivoimaging

This prospective animal study aimed to mimic arthropathic and neuropathic changes seen in human Charcot Foot in diet-induced obese mice by inducing neuro-trauma through treadmill running. Read in FAI: https://lnkd.in/g8VKgij7

I am enjoying these insightful talks from around the world at the #multiomics conference December #2024 in #Brisbane. Really eye opening! Very excited to learn about how these state of the art technologies (all the omics modalities) are being used to improve human health worldwide with lots of translational values to incorporate these into Animal health, biosecurity, agriculture and more! #spatial #transcriptomics #Pathology #H&E #Multiplex