TITAN Project EU’s Post

Our paper is out! A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex https://lnkd.in/eNq9y63e

💢How do agouti genes affect anxiety in zebrafish? Our team's newest publication uncovers the role of central serotonergic pathways. ✨Explore findings and their implications: https://lnkd.in/dm2b7bV8 CIIMAR

Characterization of the Complete Mitochondrial Genome of Eight Diurnal Hawkmoths (Lepidoptera: Sphingidae): New Insights into the Origin and Evolution of Diurnalism in Sphingids 👉Access the paper: https://lnkd.in/gnJPdgZX #mdpiinsects #Lepidoptera

de Crécy-Lagard et al. say "Analysis of 4,245 complete representative genomes in the BV-BRC database (version 3.31.12) revealed they encoded 3,714 proteins annotated as queuine tRNA-ribosyltransferase (EC 2.4.2.29)." They also note that "bDpdA proteins are currently annotated as “archaeosine tRNA-ribosyltransferase (EC 2.4.2.-) type 5” in the BV-BRC database so they cannot be mistaken for bTGT." https://lnkd.in/ei6kwDAw

Attending AGBTAg or have questions on how to simplify and extend the multiplexing capabilities for long read sequencing? Come meet the leader of the team that developed our novel Tn5 based fragmentation and tagging solution to increase your throughput and help you get more data out of your PacBio sequencing runs. #NGS #workflow #longread

🔬 How can we better understand the global HIV-1 reservoir? At #CROI2024 in Denver, Senior Scientist Dr. Hannah MacLeod presented work revealing conserved #HIV-1 reservoir landscape composition across Group M. Using AccelevirDx’s high-throughput sequencing assay, her research highlights critical insights into HIV-1 proviral defects outside Subtype B, which is key for advancing cure research globally. 🌍 👉 Discover the full findings and the development of IPDA® Version 2: https://bit.ly/3TghsBT

In a recently published study, the record-breaking largest eukaryotic genome in Tmesipteris oblanceolata, a fork fern, measured in at 160 Gbp, or more than 50 times larger than the human genome. Its massive genome likely arose through repetitive DNA accumulation and polyploidy combined. Only ~6% of fern species have been sequenced, with genome sizes ranging ~630-fold. https://hubs.ly/Q02Hkz-X0

Dorcus stag beetles are the most diverse group in Lucanidae and important saproxylic insects playing a crucial role in nutrient recycling and forest biomonitoring. We undertook mitochondrial genome sequencing of 18 species from East Asia and provided a phylogenetic analysis to construct the phylogenetic framework of  Dorcus stag beetles and thus to understand their rapid phenotypic evolution. We classified beetles into eight taxa of Linnaean taxonomy in terms of nomenclature. https://lnkd.in/dUqj4E9R

Check out our review, put together with Charikleia Karageorgiou and Omer Gokcumen on functional SVs contributing to human evolution.

My first paper is out today in GBE! A genome assembly and annotation for the webbing clothes moth. Tineola bisselliella, the webbing clothes moth, is a prolific pest species that is globally-distributed and has the ability to digest keratin. As larvae they leave their signature holes in clothes, rugs, and taxidermy. Here we present the first reference quality, pseudochromosome-level genome for the species and a genome annotation. The lack of quality genomic resources has severely limited investigations to identify the mechanism of keratin digestion and chromosome evolution of this Ditrysian moth. Now we hope this genome and annotation will be a resource for the pest management and genomics communities. https://lnkd.in/eMmZD5i5