Marisa Bedir’s Post

📣 Our second practice abstract is: High resolution analysis of multi-strain probiotic products by NGS using innovative molecular markers This abstract focuses on a new method that brings together a fast and standardized approach of NGS metabarcoding with an improved accuracy in distinguishing close related species, subspecies and strains of the same species in a blend, when compared with the current standard of 16S rRNA-based NGS metabarcoding. Authors: A. Del Casale, S. Campana, I. Campedelli, F. Fracchetti Microbion 🔗 Read the abstract here: https://ow.ly/6aRa50R86Tb #foodsafety #foodinnovation

Happy to see our latest manuscript describing the discovery and characterization of moorenaside published in the Journal of Natural Products! To the best of our knowledge, this is the first report of the anti-inflammatory activity of a cyanobacterial-derived macrolide glycoside belonging to the auriside class of natural products, targeting the Keap1/Nrf2–ARE pathway. https://lnkd.in/dM8y3_GQ

A November issue cover image from the Journal of Bacteriology highlighting work from our lab (with Archit Gupta, PhD as first author) which establishes that expelled, extracellular DNA, and proteins, together with bacterial cell surface-shed lipopolysachharide, create biofilm-simulacrums that exist in varying degrees of liquid-liquid phase separation, into which E. coli cells easily advance (with the lipopolysaccharide on their surfaces presumably also participating in the phase separation).

💢How do agouti genes affect anxiety in zebrafish? Our team's newest publication uncovers the role of central serotonergic pathways. ✨Explore findings and their implications: https://lnkd.in/dm2b7bV8 CIIMAR

Bacteriophages are highly host-specific; right? However, we have identified lytic phages against Klebsiella pneumoniae, capable of lysing at least 12 distinct bacterial species in vitro! Isn't it fascinating! Here is the link to our recent paper https://lnkd.in/gF9Tf_YT

😍 😍 😍 Welcome to read the paper "Exploring the Roles of Different DNA Repair Proteins in Short Inverted Repeat Mediated Genomic Instability: A Pilot Study" by Pooja Mandke and Karen M. Vasquez. ❤️ This pilot study shows that while ERCC1-XPF processes cruciform DNA similar to H- and Z-DNA, cruciform-induced genomic instability, unlike H- and Z-DNA, does not rely on NER and MMR mechanisms. Further, CtIP & MRE11 suppress this instability. ❤️ 👉 👉 👉 More details: https://lnkd.in/gBXfNzXk

I am super chuffed to announce that our 2024 paper on the structure-function of small heat shock proteins in tardigrades (also known as water bears) was accepted and now available online in the Cell Stress and Chaperones journal - my first publication as co-author! This was by no means an easy process as data collection came to an abrupt halt in 2020 when the COVID pandemic hit. However, I want to say a HUGE thank you to Roy Quinlan and Mohammad Al-Ansari for continuing with this work as soon as the labs were back up and running, and a special thanks to Roy for leading such an interesting research project.   In this paper, we characterise two members of the small heat shock protein family in the tardigrade Ramazzottius varieornatus, which exhibit extraordinary resilience to a range of environmental stresses (including the vacuum of space!). We explore how the structure of sHSPs impacts assembly and chaperone function. Title: The major inducible small heat shock protein HSP20-3 in the tardigrade Ramazzottius varieornatus forms filament-like structures and is an active chaperone Link: https://lnkd.in/eGX58szY

💌 💌 💌 Paper on "Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures" by Tonia T. Li and Karen M. Vasquez. 💓 💓 💓 ERCC1-XPF, a structure-specific endonuclease involved in nucleotide excision repair, can also process several mutagenic alternative (i.e. non-B) DNA structures, which can result in genome instability. https://lnkd.in/gZ--ytFK

Just published! My recent paper, "Highly Efficient Quenching of Singlet Oxygen by DNA Origami Nanostructures" has been published in Chemistry – A European Journal by Wiley In this research, we investigated the ability of different DNA origami nanostructures to scavenge reactive oxygen species during antimicrobial photodynamic inactivation of E. coli. Our findings suggest that the scavenging effect of DNA origamis are vastly superior to genomic DNA and even established reactive oxygen species scavengers in protecting the bacteria from ROS-induced damage. Read the full paper here: https://lnkd.in/ehWDWVN5 #DNA #bacteria #origami #PDT #aPDI #ROS #singletoxygen

Comparative Transcriptome Analysis between Cytoplasmic Male-sterile Line and Its Maintainer During the Floral Bud Development of Pepper https://lnkd.in/gfSmmxgS