Unchained Labs’ Post

GTxResolve SEC Columns offer high resolution, low adsorption, and robust performance for analyzing lipid nanoparticles (LNPs), nucleic acids, and viral vectors. They enable accelerated aggregate and size variant analysis, reproducible data for platform methods, and cost savings through their long shelf life. Additionally, these columns achieve low secondary interaction and provide low adsorption hardware, enhancing recovery for biologics. https://bit.ly/4ch20w2 #cellandgenetherapy #viralvectors #lipidnanoparticles #aggregateanalysis

Use of Raman Spectroscopy and PCA for Quality Evaluation and Out-of-Specification Identification in Biopharmaceutical Products In the present study, Raman spectroscopy, coupled with Principal Component Analysis (PCA), has proven to be an excellent tool for characterizing protein-based products. Notably, it offers the advantages of being minimally invasive, rapid and relatively insensitive to water. Therefore, it was successfully employed to discriminate between various stresses impacting a monoclonal antibody (mAb). The molecule used in this study is a fully human IgG1 fusion protein. Thermal stress was induced by incubating the samples at 50 °C for one month, while oxidative stress was induced by introducing hydrogen peroxide. Additionally, dilutions were performed to explore a broader range of protein concentrations. https://lnkd.in/gAfN-S87 #aspenalert #biotech #bioprocess

Lock in to compliant-ready quantification of your biologics with Lunatic, the next-gen protein quantification system! Learn how Lunatic gets you high-throughput quantification of your proteins by measuring up to 96 samples in just 10 minutes – all while flexing 21 CFR part 11 tools. Learn more here: https://lnkd.in/e7pgF8y 

Cell-based in vitro bioassays are widely used in the biopharmaceutical and biotechnology industries to support the research, development, and validation of new products 🧫 🔬 However, cell culture can be time- and resource-intensive, and not all cell-based consumables are created equal. In this blog from our partner ATCC, learn about how its ThawReady™ consumable cell format can streamline and standardise your bioassay workflows ⤵️ https://okt.to/7bPMvw

Read more about the recent advances that have made Abiologics possible from members of our founding team Mike Hamill and Jaclyn Dunphy.

Supranatural... Not a common term in biophysics and biotech space, but I love it! Flagship Pioneering, can you tell us, and/or point us the literature, to give a flavor of what AI you're leaning into for this cool direction? The prefix "supra-" means "above" or "beyond." "Natural" pertains to something existing in or derived from nature. Together, "supranatural" can imply something that goes beyond the natural, often associated with extraordinary, enhanced, or superior properties compared to what is typically found in nature. "Biologics": Biologics are products derived from living organisms or contain components of living organisms, including a wide range of products such as vaccines, blood components, gene therapies, tissues, and recombinant proteins.

Learn how #FlagshipFounded Abiologics is unlocking the next generation of biologics called Synteins™, a new biotherapeutic class with supranatural properties, revealing a world of new possibilities for patients. Jaclyn Dunphy and Mike Hamill explain how advances in generative protein design and optimization paired with automated chemical peptide synthesis are enabling this new approach to programmable biotherapeutics. Read more: https://bit.ly/4fy3sNf

👩🔬 👨🔬 Shout out to the incredible team of scientists at Abiologics, who have been pushing the boundaries of biotechnology over the past three years. 🚀 With the power of computational design and advanced peptide synthesis, we’re unlocking new therapeutic possibilities and creating biologics with unparalleled properties, reshaping the future of medicine. 📖 Dive deep into the story of our journey here

Discover how the storage stability of biologics can be improved dramatically through spray drying in our latest whitepaper - Spray Drying Biologics: An Alternative To Freeze Drying. Richard Johnson, Chief Scientific Officer, discusses the increase in complex biologics entering the market, alongside an in-depth look at the ability of spray drying to process biologics to create stable dry powders whilst maintaining tertiary structure. Download our latest whitepaper ⬇ https://lnkd.in/gPSErAft

Programmable medicines are an emerging field in medical science that combines principles from #nanotechnology, #biotechnology, and #pharmacology. These innovative therapies are designed to be more targeted, controllable, and customizable than traditional medicines. Here's a brief overview: 1. Key features: - Targeted delivery: Can be directed to specific cells or tissues - Controlled release: Medication release can be timed or triggered - Adjustable dosing: Dose can be modified based on patient response - Multifunctionality: Can perform multiple tasks, like diagnosis and treatment 2. Technologies involved: - Nanoparticles - Smart polymers - DNA/RNA-based systems - Optogenetics - #CRISPR 3. Advantages: - Increased efficacy - Reduced side effects - More precise treatment - Potential for real-time monitoring and adjustment Kudos to Flagship Pioneering to always being in the forefront of science.