Flagship Pioneering’s Post

Read more about the recent advances that have made Abiologics possible from members of our founding team Mike Hamill and Jaclyn Dunphy.

👩🔬 👨🔬 Shout out to the incredible team of scientists at Abiologics, who have been pushing the boundaries of biotechnology over the past three years. 🚀 With the power of computational design and advanced peptide synthesis, we’re unlocking new therapeutic possibilities and creating biologics with unparalleled properties, reshaping the future of medicine. 📖 Dive deep into the story of our journey here

Do you hate, hate, hate low throughput, dyes, and dilutions when it comes to quantification of your biologics? See how Lunatic, the next-gen protein quantification system, has researchers' hearts growing by delivering quantification of up to 96 samples in just 10 minutes. Learn more here: https://lnkd.in/e7pgF8y 

Macrocyclic peptides, known for their enhanced specificity, stability, and bioavailability, are gaining prominence in peptide drug discovery. Automating head-to-tail cyclization on-resin, a traditionally challenging step, has the potential to boost recovery and minimize manual intervention in peptide synthesis. Take a closer look at our poster and learn more about automated peptide synthesis: https://hubs.ly/Q02Rsygl0 #peptidesynthesis #automation #biotage

Canton Biologics' DTEasy (Difficult to Express) platform is distinguished by its efficacy and versatility. We provide a comprehensive range of vectors meticulously engineered to address varying levels of expression difficulty. 📌 In one instance, regarding tissue plasminogen activator (t-PA): Challenges we faced: 1) the non-covalent complex formed between t-PA and its inhibitor exhibited a loosely structured nature, facilitating separation; 2) the traditional purification process for t-PA generally requires three to four steps to achieve purity exceeding 90%. Solutions: We developed a dual expression vector that co-expresses t-PA in conjunction with its inhibitor, complemented by an efficient one-step chromatographic purification process. Results: The final purified yield of t-PA reached an impressive 361.5 mg/L, surpassing current technological benchmarks by more than threefold. 📈 📩 Contact us: BD@cantonbio.com #BiotechInnovation #DTEasyPlatform #ProteinExpression 

Headed to Biologics by Oxford Global meeting next week? Our biologists have worked on many types of #biologics including #genetherapy #celltherapy #antibodies #vaccines #proteinresearch If you need reliable #assaydevelopment or #translationalresearch for your biologic speak to Andrew Scott or Luka Wright

Explore the mechanism of #protein unfolding with 𝐔𝐧𝐜𝐥𝐞. 𝐔𝐧𝐜𝐥𝐞 is an all-in-one platform for understanding thermal melting, aggregation, and sizing of biologics. Measuring thermal stability can be challenging for proteins that lack intrinsic #fluorescence. That’s where the “𝐓𝐦 𝐮𝐬𝐢𝐧𝐠 𝐒𝐘𝐏𝐑𝐎” application on 𝐔𝐧𝐜𝐥𝐞 comes into play! This app uses differential scanning fluorimetry (𝐃𝐒𝐅) with SYPRO dye to easily assess protein stability. Check out the technical note to learn more. #ThermalStability #DynamicLightScattering  #lifescience #LifescienceResearch #mabs #bioanalytical #formulation #pharma #ThermalMelting

Cell-based in vitro bioassays are widely used in the biopharmaceutical and biotechnology industries to support the research, development, and validation of new products 🧫 🔬 However, cell culture can be time- and resource-intensive, and not all cell-based consumables are created equal. In this blog from our partner ATCC, learn about how its ThawReady™ consumable cell format can streamline and standardise your bioassay workflows ⤵️ https://okt.to/7bPMvw

📰📰 As you have seen this week, 2024 looks to be an amazing year for our industry. Here at Nucleus Biologics, we also have some big plans! Navigate over to our NEWS section to stay up to date on the latest, including our recent collaboration agreement with Core Biogenesis. Our blog section also contains interesting industry insights and in-depth analysis of cell culture products and processes, new product releases, and more. #biotech #lifescience #cellculture https://hubs.ly/Q02gHqfj0

Assessing Photostability of mAb Formulations In Situ Using Light-Coupled NMR Spectroscopy Biopharmaceuticals, such as monoclonal antibodies (mAbs), need to maintain their chemical and physical stability in formulations throughout their lifecycle. In this study, we used light-coupled NMR spectroscopy to monitor in situ live spectral changes in sealed samples during and after UV-A illumination of different formulations of four mAbs without added photosensitizers. We observed a complex evolution of spectra, reflecting the appearance within minutes of transient radicals during illumination and persisting for minutes to tens of minutes after the light was switched off. Both mAb and excipient signals were strongly affected by illumination, with some exhibiting fast irreversible photodegradation and others exhibiting partial recovery in the dark. These effects varied depending on the mAb and the presence of excipients, such as polysorbate 80 (PS80) and methionine. https://lnkd.in/g4V6aJQS #aspenalert #biotech #bioprocess