Vesiculab’s Post

Exploring the potential benefits of food-derived extracellular vesicles: in this perspective article, Natalie Turner at QUT (Queensland University of Technology) made a case for intensifying community-wide attention towards comprehending the cellular uptake of food-derived EVs originating from diverse animal, plant, yeast, and bacterial species, and its potential impact on human function https://lnkd.in/eHAbRzPC This understanding bears implications for both human health and therapeutic strategies #extracellularvesicles #exosomes #foodresearch #translationalmedicine #Vesiculab

  • Top image: Pasteurisation and lyophilisation may change the surface profile of FDEVs. (1) Structural or conformational changes of the EV surface profile inhibits uptake by recipient cells. Reduced uptake of EVs limits their biological capabilities. (2) The mechanism of EV uptake by recipient cells is altered due to changes in EV membrane protein marker expression and thus the downstream fate of EV cargo is also altered. This has implications for the way EV cargo is processed and potentially changes or inhibits biodistribution. (3) The affinity for recipient cell type is affected such that EVs are taken up by, for example, immune cells rather than GI epithelial cells, also altering the fate of EV cargo. Created with BioRender.com. EV, extracellular vesicle; FDEVs, food-derived extracellular vesicles.
Bottom image: Schematic of possible changes occurring to the EV surface and structure due to pasteurisation and/or lyophilisation. Created with BioRender.com.
Mostafa Kamal Masud, PhD, MRSC

CCQ Next Generation Cancer Research Fellow at Australian Institute for Bioengineering and Nanotechnology (AIBN)

8mo

Congratulations

Petter Järemo

Consultant cardiology and scientist

8mo

Very interesting

See more comments

To view or add a comment, sign in

Explore topics