Virmedex’s Post

Our NT-proBNP ELISA #Assay was utilized in a recent study investigating factors contributing to the high mortality rate among #dialysis patients with #kidneyfailure, beyond the conventional #cardiovascular risk factors. The research focused on the relationship between #gutpermeability, circulating bacterial fragments, and volume overload in peritoneal dialysis patients. Find out more: https://buff.ly/3z9nzR2 #biomedica #biomedicaimmunoassays #heartdisease #endstagerenaldisease #dialysis #NT-proBNP

ECMELLA or ECMO+Impella is a very effective technique to achieve systemic perfusion AND LV offloading for myocardial recovery. This is increasingly used in post-cardiotomy patients, ECPR/STEMI patients with excellent outcomes. #ECMO #IMPELLA #ECPR #Shock #cardiacarrest #criticalcare

This study explores the efficacy of a novel ECMELLA setup combining veno-arterial extracorporeal membrane oxygenation (va-ECMO) with a micro-axial flow pump in treating cardiogenic shock (CS). Analyzing data from 67 patients treated between December 2020 and December 2022, the study found the technique feasible and effective, with a 27% myocardial recovery rate and a 24% transition rate to #CardiogenicShock #ECLS #ECMELLA #Impella #VAECMO

❓ What’s the best vascular access for haemodialysis patients? Thus far, arteriovenous fistulas (AVF) have been the primary choice among experts. (1,2) Central-venous catheters (CVC) come next in line as a secondary option, due to the risk of complications. ❗ Recent findings, however, have challenged this approach: In 2023, Navarro et al. published a study comparing the inflammatory profiles of patients with native AVFs and CVCs. (3) Patients with CVCs used either heparin or TauroLock™-HEP500 as a lock solution.  The results after a period of 3 months: ➡️ No significant changes of inflammatory markers with AVF   ➡️ Significant increase of inflammatory markers with CVC + heparin  ➡️ Significant decrease of inflammatory markers with CVC + TauroLock™-HEP500 Eventually, the inflammatory profile of patients with CVCs using TauroLock™-HEP500 did not differ from that of patients with native AVFs. (3) This discovery is of particular importance considering the correlation between inflammation and biofilm. (4,5) 💡 If TauroLock™-HEP500 can reliably prevent both – might CVCs locked with this product work just as well as AVFs? #taurolock #tauropharm #dialysis #infectionprevention #antimicrobial 1) Schmidli et al. Eur J Vasc Endovasc Surg 2018. DOI: 10.1016/j.ejvs.2018.02.001  2) Lok et al. Am J Kidney Dis 2020. DOI: 10.1053/j.ajkd.2019.12.001   3) Navarro et al. Nephrol Dial Transplant 2023. DOI: 10.1093/ndt/gfad063b_3195  4) Cappelli et al. Nephrol Dial Transplant 2005. DOI: 10.1093/ndt/gfh571  5) Fontseré et al. Antimicrob Agents Chemother 2014. DOI: 10.1128/AAC.02421-14 

Elevated plasma fibrinogen levels in multiple sclerosis patients during relapse Miranda Acuña J, Hidalgo de la Cruz M, Ros AL, Tapia SP, Martínez Ginés ML, de Andrés Frutos CD. Elevated plasma fibrinogen levels in multiple sclerosis patients during relapse. Mult Scler Relat Disord. 2017 Nov;18:157-160. doi: 10.1016/j.msard.2017.09.033. Epub 2017 Sep 30. PMID: 29141800. https://lnkd.in/ek8MhES2 If measurements of 25(OH)D3 and/or calcitriol reveal deficiency, supplement to bring fibrinogen to 2.5 grams/liter. Otherwise, consider Ivermectin to reduce fibrinogen from elevated levels down to 2.5 grams/liter. Feedback from those I dealt with during COVID-19 with MS reveal a stark improvement with supplementation to correct D3 deficiency. #MS #hyperfibrinogenemia #supplement D3 #lab tests when feasible

The Biomedica soluble #SEMAPHORIN 4D #Assay Kit was utilized in a recent study assessing the role of #SEMA4D as a #biomarker in #criticallyill and septic patients. The results revealed that blood SEMA4D concentrations are significantly increased in patients with #liver cirrhosis and are positively correlated with liver function tests. The study suggests that SEMA4D may be associated with #hepaticinjury and #inflammation. Learn more: https://lnkd.in/gRYF3KBr #biomedica #biomedicaimmunoassays #ELISA #Semaphorin4D #CD100 #ICU #sepsis #organfailure

Epoetin alfa reduces transfusion dependence and improves hemoglobin in low-risk #MDS patients, especially those with lower baseline EPO levels, a new study finds. #hematology Cureus Journal of Medical Science Read more here: https://lnkd.in/eHS5Szk4

publication of our manuscript: Comparison between the effect of angiotensin-converting enzyme inhibitors and angiotensin receptors blockers and their combination on mortality in maintenance dialysis patients: a systematic review and meta-analysis https://lnkd.in/dyr_TpRU

The study demonstrates that basal and interim [68Ga]Ga-DOTA-TOC PET/CT scans, through proportional changes in WTV and TRE, effectively predict PFS in neuroendocrine tumour patients receiving PRRT https://lnkd.in/dq7bEu8g

Meta-analysis of clopidogrel monotherapy vs aspirin alone long-term after DES.. “ Clopidogrel reduced the risk of major adverse cardiovascular events by 28% versus aspirin and there was a similar risk of major bleeding after adequate dual antiplatelet therapy in acute coronary syndrome patients post-drug-eluting stent implantation.” https://lnkd.in/e7xPt2gB