Xtalks’ Post

Isolation of monoclonal colonies, NOT single cells! The benefits of flask-like culture for improving single cell colony formation  We are excited to present the latest application note from our partner Cell Microsystems. The app note "Accelerate Cell Line Development by Isolating Monoclonal Colonies, NOT Single Cells," is now ready for download. This comprehensive study redefines cell line development strategies, spotlighting the effectiveness of flask-like culture conditions in significantly bolstering single-cell colony formation.  Check out the website and download the app note. https://lnkd.in/ea-WX5Ud #singlecells #celllines #cellculture #biotechnology

The identification and selection of optimal clones that express high levels of a desired antibody is a critical and time-consuming step in the antibody discovery process. Learn how CellCelector significantly accelerates the process, compared to conventional techniques. #antibodydiscovery #lifescience #cellcelector

Let's talk about the advantages of NanoEntek cell counters for your lab ☕ If it looks like a fit, next step could be a demo at your site ✔️

💾 Wrap 'n' Roll: Revolutionizing Tubular Organ-on-a-Chip Models with Cell Pre-Wrapping Organ-on-a-chip (OOC) models are the latest craze in studying human biology and developing new medicines, thanks to their microfluidic technology. But they’re not perfect—traditional OOCs struggle with flat designs, stiff materials, and tricky cell placement. Enter the hero: a new cell seeding technique that pre-wraps cells around sacrificial fiber templates. This game-changer creates more lifelike, circular tubular structures, like tiny kidneys with twists and turns. Demonstrated with a renal proximal tubule-on-a-chip, this approach promises a future of diverse and dynamic OOC models, making the study of diseases and drug development more exciting and accurate. Learn more! https://lnkd.in/gDaMVNfZ

Joshua Carter from Helix Biostructures will present his talk on "Gene-to-Structure Services: Helping Explore and Understand Molecular Modalities Using Biophysical and Structural Characterization" on October 9th from 1:40-2:10 PM ET. Talk Overview - Overview of Helix BioStructures gene-to-structure services (custom protein production, biophysical characterization, crystallography, SAXS, and cryo-EM) - Modality trends seen at Helix - Key changes seen in early drug discovery over the past 5-10 years - Learn how Helix is building into the future to meet demands and innovate the gene-to-structure process Register by clicking on the image below. #newmodalities #freewebinar https://lnkd.in/edCH-5bM

✨ In our latest blog post, we share some tips and tricks for harnessing the power of hydrogels for 3D cell culture, from selecting the right type of biomaterial to optimising cell culture conditions. Check it out here: https://lnkd.in/e3Mr4t2C #3dcellculture #hydrogels #animalfree #biomaterials

I noticed two very cool new single cell technologies at the ELRIG conference in London today. 𝗟𝗶𝗴𝗵𝘁𝗖𝗮𝘀𝘁: This innovative technology uses light to control picoliter droplets containing cells and/or reagents. It allows for the merging of droplets with different cells, enabling real-time imaging of cell-cell interactions on-chip. I think this will be particularly useful for studying the effects of antibodies or signaling at the single-cell level. https://www.lightcast.bio/ 𝗦𝗽𝗵𝗲𝗿𝗲 𝗙𝗹𝘂𝗶𝗱𝗶𝗰𝘀: This high-throughput device encapsulates cells in picoliter droplets along with reagents, maintaining cell viability for observation. While it doesn’t offer the droplet control and merging capabilities of LightCast, it looks like its throughput potential is more powerful. https://lnkd.in/d6hNUTcd Both technologies would greatly benefit from enhanced compatibility with downstream single-cell sequencing. Integrating phenotypic data from these platforms with molecular insights from sequencing would provide a more comprehensive solution for single cell analysis. #Biotech #SingleCellAnalysis #Innovation #ELRIGConference #LightCast #SphereFluidics

💊 𝗔𝘁 𝗣𝗵𝗶𝗻𝗖 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁, 𝘄𝗲 𝘂𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱 𝘁𝗵𝗮𝘁 𝘁𝗵𝗲 𝗔𝗗𝗠𝗘 𝗽𝗿𝗼𝗰𝗲𝘀𝘀 𝗶𝘀 𝗰𝗿𝘂𝗰𝗶𝗮𝗹 𝗶𝗻 𝘆𝗼𝘂𝗿 𝗱𝗿𝘂𝗴 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁. This step determines how a drug is absorbed into the bloodstream, distributed to tissues, metabolized by the body, and ultimately eliminated. Through advanced modeling and simulation, particularly using #PBPK (Physiologically Based Pharmacokinetic) approaches, we can predict these processes with remarkable accuracy. By considering the physicochemical properties of the drug, 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 biotransformation and transport data, and the anatomy and physiology of the human or animal body, our models facilitate dose optimization and regimen design. ➡ Learn how: https://lnkd.in/dSatNmtA

Navigate the complexities of CAR-T cell manufacturing with confidence using the Maxwell® RSC instrument. From the extraction of genomic DNA to the final analysis of STR profiles, ensuring cell identity has never been more streamlined. Our solutions help secure the accuracy of patient-derived CAR-T cells, crucial for the success of personalised therapies. Discover how we can support your science by requesting a demonstration today! 🔗 Learn more about enhancing your CAR-T cell workflows at https://bit.ly/3MThbkM #GenomicIntegrity #NucleicAcidExtraction