Transthyretin Amyloidosis Treatment Market To Grow At 8.6% CAGR Till 2033

The global transthyretin amyloidosis treatment market size was exhibited at USD 6.72 billion in 2023 and is projected to hit around USD 15.33 billion by 2033, growing at a CAGR of 8.6% during the forecast period 2024 to 2033.

Transthyretin Amyloidosis Treatment Market by Overview 

Transthyretin Amyloidosis (ATTR) represents a complex and challenging condition within the realm of rare diseases, necessitating a nuanced understanding of its treatment landscape. With advancements in medical research and therapeutic interventions, the ATTR treatment market has witnessed notable evolution in recent years. This comprehensive overview aims to delve into the current state of the Transthyretin Amyloidosis Treatment Market, offering insights into key drivers, market dynamics, treatment modalities, and future prospects.

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Transthyretin Amyloidosis Treatment Market Growth Factors

The growth of the Transthyretin Amyloidosis Treatment Market is propelled by several key factors. Firstly, heightened awareness and improved diagnostic capabilities have led to early detection and intervention, driving market expansion. Additionally, advancements in therapeutic modalities, such as TTR stabilizers and gene-silencing therapies, offer novel treatment options, fostering market growth. Furthermore, regulatory initiatives aimed at expediting the approval process for orphan drugs stimulate research and development efforts, fueling innovation within the market. Collaborative endeavors between pharmaceutical companies, research institutions, and patient advocacy groups also play a pivotal role in driving research advancements and expanding the treatment landscape. Overall, these factors collectively contribute to the robust growth of the Transthyretin Amyloidosis Treatment Market, promising improved outcomes for patients afflicted with this challenging condition.

Key Takeaways:

• North America dominated the market with a revenue share of over 67.0% in 2021.
• ATTR-CM dominated the market for transthyretin amyloidosis and accounted for a revenue share of more than 80.0% in 2021. 
• ATTR-PN is estimated to register the highest growth rate over the forecast period.
• Hereditary transthyretin amyloidosis captured the largest revenue share of over 60.0% in 2021.
• Hospital pharmacies captured the largest revenue share of over 30.0% in 2021.
• The targeted therapy segment dominated the market and accounted for a revenue share of over 92.0% in 2021.

Transthyretin Amyloidosis Treatment Market Trends

• Emergence of Disease-Modifying Therapies: Disease-modifying therapies targeting the underlying cause of ATTR amyloidosis have been a significant advancement. Drugs like Tafamidis, Patisiran, and Inotersen have gained approval in various regions, offering options for both hereditary and wild-type forms of the disease. These drugs work by stabilizing transthyretin (TTR) or reducing its production, thereby slowing disease progression.
• Increased Focus on Early Diagnosis: Early diagnosis is crucial for effective management of ATTR amyloidosis. There's a growing emphasis on raising awareness among healthcare professionals about the disease's varied manifestations and the importance of early identification. Diagnostic techniques like imaging studies, genetic testing, and biomarker assays are aiding in timely diagnosis.
• Expanding Pipeline: The ATTR treatment pipeline continues to expand with various novel therapies in different stages of clinical development. This includes gene silencing therapies, small molecule inhibitors, monoclonal antibodies, and gene editing approaches. These investigational drugs aim to address unmet needs, such as improving efficacy, reducing treatment burden, or targeting specific patient populations.

Some of the prominent players in the Transthyretin amyloidosis treatment market include:

• Pfizer Inc.
• Johnson & Johnson Services, Inc.
• Ionis Pharmaceuticals, Inc.
• Alnylam Pharmaceuticals, Inc.
• BridgeBio Pharma, Inc.
• Bristol-Myers Squibb Company
• Acrotech Biopharma
• AstraZeneca
• Astellas Pharma, Inc.
• Prothena
• SOM Biotech 

Segments Covered in the Report

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Nova one advisor, Inc. has segmented the global transthyretin amyloidosis treatment market.

Type

• ATTR-PN
• ATTR-CM

Therapy

• Targeted Therapy
• Supportive Therapy
• Pipeline Therapy

Disease Type

• Hereditary Transthyretin Amyloidosis

• Polyneuropathy
• Cardiomyopathy
• Mixed Type

• Wild Type Amyloidosis

Distribution Channel

• Hospital Pharmacies
• Specialty Pharmacies
• Retail Pharmacies
• Online Pharmacies

Transthyretin Amyloidosis Treatment Market By Regional Insights

North America dominated the market with a revenue share of over 67.0% in 2023 and the region is anticipated to maintain its dominance during the forecast period. Increasing novel drugs prescription, proper reimbursement policies, and higher treatment rates in the region are factors supporting transthyretin amyloidosis treatment market growth in the region. The introduction of new therapies in the region is acting as a key market driver. For instance, in July 2019, Health Canada approved ONPATTRO for the treatment of hATTR with polyneuropathy in adults. This approval is projected to have a positive impact on the regional market.

The MEA region is projected to witness the fastest growth over the forecast period. The high unmet treatment needs, increasing prevalence of disease, and rising approval are expected to drive the market in the coming years. Moreover, major factors such as a large target population, good healthcare reforms, and an increase in disease awareness are expected to be the primary growth factors.

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