INITIALISE

🧬 Metabolism, Immunity & Type 1 Diabetes Progression A recent study, "Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children," reveals a compelling connection between immune system modulation and metabolic pathways in diabetes progression. Beyond glucose metabolism, researchers found that rapid progressors to Type 1 diabetes exhibited increased levels of specific amino acids, including tryptophan metabolites, which play a crucial role in immune regulation. 🔬 These findings highlight potential biomarkers for early intervention and open avenues for precision medicine approaches targeting immune-metabolic interactions. 🔍 Such insights could shape early interventions and new strategies to support immune and metabolic health. 📖 Read the full study: https://lnkd.in/eynVHEBM #Type1Diabetes #MetabolicHealth #AminoAcids #ImmuneRegulation #EarlyLifeHealth #DiabetesResearch #PrecisionMedicine #AutoimmuneDiseases #Tryptophan #Biomarkers #Immunometabolism #Endocrinology #TranslationalResearch #PreventiveMedicine #SystemsBiology Tuulia Hyötyläinen Matej Oresic

The INITIALISE project uses eight longitudinal birth cohort studies to track immune development and environmental exposures, providing valuable insights into how these factors influence health from early life. 🧬👶 Through this detailed tracking, the project aims to uncover connections that may lead to personalised interventions and preventative strategies against immune-mediated diseases.🛡️💡 🔗For more information on INITIALISE's research, visit the project website: https://lnkd.in/eDvEEWYU #EarlyIntervention #EarlyLife #ImmuneSystem #MultiOmics #GutMicrobiome #Exposure #Immune #Immunemediated #Disease #Genomics #Environment #Chemicals #Childhealth #Personalised #Health #HealthResearch #ImmuneMediatedDiseases #PreventiveCare #Strategies #EUproject

🥗 The Power of Maternal Nutrition 🍽️: A recent study reveals that a high-fat diet during pregnancy can alter a newborn's gut microbiota 🧬, potentially leading to inflammation and increased risks of obesity and metabolic diseases. 🌱 This underscores the importance of balanced maternal nutrition for a healthy start to life. Moms-to-be, let’s make nutrition a priority for our little ones' futures! 🤰🍎 👉 Explore the study in full: https://lnkd.in/eXdxUtwm #MaternalHealth #PregnancyNutrition #GutHealth #EarlyLifeHealth #Inflammation #Risk #Obesity #Highfatdiet #Diet #Metabolic #Diseases #MetabolicHealth #ObesityPrevention #PublicHealth #NutritionMatters

🌍 🧬Transforming Precision Medicine through Omics and Metabolic Modeling  Integrating omics data into genome-scale metabolic models (GEMs) is setting new standards in personalized healthcare. 💡 This innovative shift offers deeper insights into metabolic ⚙️ and microbiome 🦠 interactions, powered by advanced machine learning 🤖. As we boost model accuracy and precision 🎯, the potential for tailored medical treatments 💊 grows exponentially! 📈 👉Dive into this comprehensive perspective authord by Matej Oresicšič and Partho Sen, MS, PhD: https://lnkd.in/eCkFAhZP #PrecisionMedicine #PersonalizedMedicine #OmicsData #MetabolicModeling #MachineLearning #Genomics #HealthInnovation #PersonalizedHealthcare #Turun yliopisto - University of Turku Örebro University

On October 25 -29th, the V Argentine Congress of Mass Spectrometry (V-CAEM) convened in Buenos Aires, Argentina, focusing on advancements in mass spectrometry. Our Principal Investigator, Matej Oresic from our work package partner Turun yliopisto - University of Turku presented on : 🎤“Microbiome-Derived Bile Acids During Early Life: Insights into the Progression to Islet Autoimmunity” The presentation explored the role of gut microbiome-derived bile acids in early-life immune development and their association with the onset of islet autoimmunity, a precursor to Type 1 Diabetes. 💡 Key Takeaways from the Presentation: 🔹 Gut Microbiome and Bile Acids: The gut microbiome shapes bile acid composition, playing a critical role in immune regulation during early life. 🔹 Islet Autoimmunity: Altered bile acid profiles were linked to islet autoimmunity, a precursor to Type 1 Diabetes, offering potential pathways for early intervention. 🔹 Mass Spectrometry Insights: Cutting-edge mass spectrometry techniques revealed intricate details about bile acid metabolites and their role in immune modulation. 📈 This research underscores the importance of the gut microbiome and its metabolites in immune system development and offers potential biomarkers for early detection of autoimmune conditions. 🔗 For more information on V-CAEM, visit: https://lnkd.in/eNdjehHG #MassSpectrometry #GutMicrobiome #Autoimmunity #BileAcids #T1DResearch #ScientificAdvancements 🔬🧪

🍼🦠 Breastfeeding's Hidden Superpower! Exclusive breastfeeding can help C-section babies develop gut microbiota similar to those born vaginally! 🌟 This highlights the incredible role of breastfeeding in supporting early-life gut health and paving the way for overall long-term wellness. 💡 Discover how early nutrition shapes lifelong health in this study. 🔗 Read more here: https://lnkd.in/e8cY-uym #Breastfeeding #GutHealth #EarlyLifeNutrition #InfantHealth #MaternalWellness #LongTermHealth #ChildDevelopment #HealthcareResearch #PublicHealth #Wellbeing 👶🌱✨

🌟The first 1,000 days of life represent a critical window of opportunity for developing gut microbiota 🦠 and the immune system. 🧬 During this time, maternal factors like obesity and diet 🥗 can play a significant role in shaping a child's health for years to come. 🌱 Explore how early life influences long-term wellness and what this means for future generations👶. 📚👉 Read more in the study: https://lnkd.in/e8cY-uym #EarlyLifeHealth #GutMicrobiota #MaternalHealth #InfantNutrition #LongTermHealth #Immunity #ChildDevelopment #HealthcareResearch #PublicHealth #HealthyStart #PrenatalCare #Wellbeing

Our work package partners, the Department of General Practice University Medical Center Groningen (UMCG) and the Spanish National Research Council (CSIC) have made significant strides in understanding the early life microbiome and its impact on health. Here's a snapshot of their recent contributions at two prestigious international conferences. 🌐 UMCG at the Cold Spring Harbor Microbiome Conference On October 29 - November 2, Professor Alexandra Zhernakova presented on the topic of 🦠 "Evaluating Early Life Virome Using Metagenomic and VLP-Enriched Methods." This highlights important research on how the gut virome—the collection of viruses in our digestive system—develops during early life, the crucial role of the early virome in shaping immune responses, and its potential impact on long-term health outcomes. 🍼 CSIC at the XIII International Conference on Immunonutrition (ISIN) On October 28 - 31, 2024, Dr. Maria Carmen Collado presented on 👶 "Beyond Nutrition: The Critical Role of Human Milk in Shaping Infant Microbiota and Health Outcomes." She highlighted how breastfeeding—including beneficial microbes, human milk oligosaccharides (HMOs), and metabolites—plays a vital role in developing an infant's microbiome and influences health outcomes well into later life, underlining the importance of breastfeeding in public health strategies. 🔗 Learn more about the conferences: https://lnkd.in/eSWg-fAA https://lnkd.in/eAx4R7h7 #Microbiome #Virome #GutHealth #EarlyLife #Breastfeeding #HumanMilk #InfantHealth #ImmuneSystem #PublicHealth #CSH2024 #ISIN2024 #Microbiota #HealthOutcomes #Immunonutrition #Metagenomics #VLPMethods #HumanMilkOligosaccharides #HMOs #InfantMicrobiota #Conference #Science #ResearchImpact #ViromeResearch #EarlyLifeHealth #InfantNutrition

🔬 Did you know PFAS, those man-made chemicals lurking in everyday products, can cross the placenta during pregnancy? This could potentially impact your baby's development and increase their risk of type 1 diabetes. 🚼 Expecting mothers, it's crucial to stay informed about the potential health risks of PFAS exposure. Your baby's long-term health starts now! 💪 Dive deeper into the research: https://lnkd.in/e9gNw553 #PrenatalCare #EnvironmentalHealth #EarlyLifeHealth #MaternalHealth #Type1Diabetes #PublicHealth #PregnancyWellness #LongTermHealth #HealthcareResearch

Early Life Matters: The Impact of Birth Mode on Infant Health🤰👶 🦠🤱 👶The way a baby enters the world can significantly influence their long-term health. Vaginal delivery exposes newborns to beneficial maternal microbiota, setting the stage for a healthy gut microbiome. Let's work towards understanding and promoting practices that support optimal infant health from the very beginning. Link to the study:  https://lnkd.in/e8cY-uym #InfantHealth #BirthMode #EarlyLifeWellness #GutHealth #Microbiota #MaternalHealth #Microbiome #PublicHealth #Pediatrics #Healthcare #NewbornCare #PublicHealth #ChildDevelopment #Pediatrics #HealthcareResearch #Wellbeing #HealthyStart #PrenatalCare