Journal of Thrombosis and Haemostasis (JTH)

"Kyle J Comishen et al. have conducted a systematic review and meta-analysis exploring the etiology and diagnostic approaches for Heavy Menstrual Bleeding (HMB) among adolescents and adults. Their research, which included over 41,000 patients, highlights the significant prevalence of bleeding disorders in this population, particularly among adolescents. This study underscores the importance of comprehensive evaluations for HMB to improve management and patient quality of life." Read more about this study: https://lnkd.in/gMFCduDk Authors: Kyle Comishen | Meha Bhatt | Katie Yeung | Jehan Irfan | Ayesha Zia, MD, MSCS | Robert Sidonio, MD,MSc Jr | Paula James

New research by Helen Hy Yao and Walter Ha Kahr delves into the molecular intricacies of platelet granule biogenesis, uncovering the genetic and protein structures that underpin defects in platelet function. Their comprehensive review highlights crucial findings from studies on conditions like ARPC1B deficiency and Hermansky-Pudlak Syndrome, enhancing our understanding of platelet biology and its implications for clotting, inflammation, and disease treatment. Read more about this study: https://lnkd.in/gCi5acgr Authors: Helen Hy Yao | Walter Ha Kahr

Explore the newly published ISTH Hemophilia Guidelines with a critical review by Guy Young et al. in the latest JTH in the Clinic article. This review deconstructs the guidelines, addressing the challenges clinicians face due to the predominantly conditional nature of the recommendations. The team provides a clearer, more actionable path forward by integrating recent literature and extensive clinical experience from across four continents. Read more about this study: https://lnkd.in/gxb9qA5u Authors: Guy Young | Riitta Lassila | Jane Mason | SASKIA PRASCA

JTH Countdown Top 10 Article of 2024! Anticoagulation for stroke prevention in atrial fibrillation and treatment of venous thromboembolism and portal vein thrombosis in cirrhosis: guidance from the SSC of the ISTH Read more about this study: https://lnkd.in/gAGabkcF Authors: Stephanie Carlin | Adam Cuker | Alexander Gatt | Nicolas Gendron | Virginia Hernández-Gea | Karina Meijer | Deborah Siegal | Simon Stanworth | Ton Lisman | Lara Roberts

JTH Countdown Top 10 Article of 2024! Endothelial protein disulfide isomerase A1 enhances membrane stiffness and platelet-endothelium interaction in hyperglycemia via SLC3A2 and LAMC1 Read more about this study: https://lnkd.in/gNN_vePs Authors: Renato Gaspar | Álefe Roger Silva França | Percillia Victoria Santos Oliveira | Joel Félix Silva Diniz Filho | Livia Teixeira | Iuri Cordeiro Valadão | Victor Debbas | Clenilton Costa dos Santos | Mariana Pereira Silva | Silvina Odete Bustos | Luciana Magalhães Rebelo Alencar | Graziella Eliza Ronsein | FRANCISCO LAURINDO

JTH Countdown Top 10 Article of 2024! International Society on Thrombosis and Haemostasis clinical practice guideline for treatment of congenital hemophilia A and B based on the Grading of Recommendations Assessment, Development, and Evaluation methodology Read more about this study: https://lnkd.in/gpfKv2yb Authors: Suely Rezende | Ignacio Neumann | Pantep Angchaisuksiri | Omolade Awodu Awodu | Ana Boban | Adam Cuker | Julie Curtin | Karin Fijnvandraat | Samantha Gouw | Roberta Gualtierotti | Michael Makris | Paula Nahuelhual | Niamh O’Connell | Renu Saxena | Midori Shima | Runhui Wu | Frits Rosendaal

JTH Countdown Top 10 Article of 2024! Clinical outcomes after discontinuing anticoagulant therapy in patients with first unprovoked venous thromboembolism Read more about this study: https://lnkd.in/gprhp8jZ Authors: Cristina Gabara | Jesus Aibar | Yuji Nishimoto | Yugo Yamashita | Paolo Prandoni | Geoffrey Barnes | BEHNOOD BIKDELI | David Jimenez | Pablo Demelo Rodríguez MD, PhD | Ma Luisa Peris | Son Truong Nguyen | Manuel Monreal The Registro Informatizado Enfermedad Trombo Embólica Investigators

JTH Countdown Top 10 Article of 2024! Reversal of direct oral anticoagulants: guidance from the SSC of the ISTH Read more about this study: https://lnkd.in/g8hpCZNv Authors: Jerrold Levy | Joseph R. Shaw | Lana Castellucci | Jean Connors | Douketis James | Edelgard Lindhoff-Last | Bianca Rocca | Charles Marc Samama | Deborah Siegal | Jeff Weitz

JTH Countdown Top 10 Article of 2024! Three-year outcomes of valoctocogene roxaparvovec gene therapy for hemophilia A Read more about this study: https://lnkd.in/gdk7eh-B Authors: Bella Madan | Margareth C Ozelo | Priyanka Raheja | Emily Symington | Doris Quon | ANDREW H. LEAVITT, D.D.S., M.S.D., P.S | Steve Pipe | Gillian Lowe | Gili Kenet | Mark Reding | Jane Mason | Michael Wang | Annette von Drygalski | Robert Klamroth | Sue Shapiro | Hervé CHAMBOST | Amy L. Dunn | Johannes Oldenburg | Sheng-Chieh Chou | Flora peyvandi | Carolyn Millar | Dane O. | Hua Yu | Ebony Dashiell-Aje, PhD | Tara M. Robinson | Johnny Mahlangu

JTH Countdown Top 10 Article of 2024! Utility of the modified Ottawa score for identification of more preferable candidates of extended anticoagulation therapy in cancer-associated isolated distal deep vein thrombosis: insight from the ONCO DVT Study Read more about this study: https://lnkd.in/g7z4esmj Authors: Wei Xiong | Yugo Yamashita | Takeshi Morimoto | Nao Muraoka | Michihisa Umetsu | Yuji Nishimoto | Takuma Takada | Yoshito Ogihara | Tatsuya Nishikawa | Nobutaka Ikeda | Kazunori Otsui | Daisuke Sueta | Yukari Tsubata | Masaaki Shoji | Ayumi Shikama | Yutaka Hosoi | Yasuhiro Tanabe | Ryuki Chatani | Kengo Tsukahara | Naohiko Nakanishi | Kitae Kim | Satoshi Ikeda | Koh Ono | Takeshi Kimura ONCO DVT Study Investigators