EMILY KWONG: You're listening to Short Wave from NPR.
REGINA BARBER: Hey, Short Wavers, Regina Barber here. And I'm here with my colleague, NPR health correspondent and awesome guy, Rob Stein. Hey, Rob.
ROB STEIN: Hey, Gina.
BARBER: I hear that you've been working on this really interesting story for the past year.
STEIN: Yeah, yeah. I've been the developments of a biotech company called Revivicor that's been moving towards a very ambitious goal. And that is to use cloned, genetically modified farm animals to provide organs for transplants for humans.
BARBER: OK, so you're saying farm animals. So there's, like, a farm just full of cloned animals?
STEIN: Yeah, yeah. In fact, I went to visit this farm. I drove down a road through the Blue Ridge Mountains in southwest Virginia to visit the Revivicor farm back in February. This farm, it has like 22 buildings and around 300 pigs.
[PIGS OINKING]
STEIN: We had to change into hospital scrubs before going inside to protect the pigs. They're really careful to make sure visitors don't bring in any pathogens that could infect the pigs. When we went into the buildings, we stepped into these tubs of disinfecting fluid to sterilize our boots. And then I got to see these cloned, genetically-modified adult female pigs.
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SPEAKER: Do you want to hold one?
STEIN: Aw. It's OK. Yeah, yeah, it's OK.
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STEIN: And some of them were pregnant with cloned pig embryos that were also genetically modified.
BARBER: Wow, you're, like, breaking my brain here. OK, so there are these identical organs in all of these pigs, so they can be used in humans, right?
STEIN: That's the idea. That's right.
BARBER: Wow.
STEIN: They cloned these pigs. They all have these 10 identical genetic modifications. And they're designed to make sure their organs-- these piglets that are born-- don't grow too big, won't cause complications like blood clots, and won't be rejected by the human immune system.
BARBER: This sounds very like sci-fi film.
STEIN: It did to me, too, especially when I first heard about it. But it's real. And they're trying to address a very real problem, which is that more than 100,000 people are on the waiting list for transplants in the US, and about 17 die every day without getting one, because there just aren't enough human organs available.
BARBER: It is devastating.
STEIN: Yeah. And last month, I was there for the very first transplant surgery of one of the Revivicor kidneys with these 10 genetic modifications into a living patient.
BARBER: Wow, you saw the surgery?
STEIN: Yeah, I was inside the OR for the entire operation. And, you know, Gina, this is, I should say, very controversial, in a lot of ways. I talked to bioethicists and scientists who have a lot of concerns, you know, concerns about the pigs, about the patients themselves, who are desperate for anything, and even the possibility that this could cause a pandemic by spreading pig viruses to people.
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BARBER: So today on the show, the first living person to receive a new kind of genetically modified pig kidney, and what that could mean for the future of transplant medicine. You're listening to Short Wave, the science podcast from NPR.
BARBER: OK, Rob, so you were the only journalist allowed in the operating room, right? So, like, set the scene. How was it?
STEIN: So this operating room is in New York City. And in the room, there was this huge screen on the wall with the flight path of one set of surgeons. They're flying back from rural Virginia with two kidneys from one of the cloned gene-edited pigs being bred at the Revivicor research farm.
BARBER: Wow. OK, so who is this patient being operated on, receiving this transplant?
STEIN: Yeah, I met her a few minutes before they brought her into the OR. She's a 53-year-old grandmother. Her name is Towana Looney. She donated one of her kidneys to her mother in 1999.
BARBER: Aw.
STEIN: A few years later, she developed chronic high blood pressure during a pregnancy, and her remaining kidney failed in 2016. And since then, she's been on dialysis four hours a day, three days a week.
BARBER: So she's been dealing with this for almost a decade.
STEIN: Yeah.
BARBER: OK, and this treatment, like transplanting an organ from another animal, it's a new experimental approach, right?
STEIN: Oh, absolutely. It's very experimental. There have been other patients who've received other kinds of gene-edited pig kidneys and even hearts, and those organs seem to work well.
BARBER: Yeah?
STEIN: But the patients in those cases were gravely ill with many other health problems and only survived weeks or maybe months.
BARBER: Oof.
STEIN: But like I said earlier, this is the first transplant of this specific kind of genetically modified pig kidney into a living person.
BARBER: Yeah, I don't think I've heard of clinical trials for this. Aren't those required before human patients can get these, like, experimental treatments?
STEIN: Yeah, that's right. In fact, the company's in conversation with the FDA to get approval for this right now, but it hasn't happened yet. So this was an exception to the FDA's usual requirements. It's called a compassionate use case, which, you know, gives patients who are desperately ill and basically have no other options access to experimental treatments. And Towana has an especially sensitive immune system, so doctors knew her body would reject a human kidney.
BARBER: Oh, no.
STEIN: But in the operating room, everyone was pretty optimistic.
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ROBERT MONTGOMERY: She's in better condition than the other patients who have undergone this procedure, so we're hopeful.
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STEIN: That's the lead surgeon, Dr. Robert Montgomery. I watched as an anesthesiologist put Towana under.
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MONTGOMERY: Everybody ready?
SPEAKER: Yeah.
BARBER: Wow.
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STEIN: And then the surgical team got to work. Robert, the surgeon, made an incision in Tijuana's lower abdomen to begin painstakingly preparing a spot to implant the pig kidney.
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MONTGOMERY: OK, scissors, the long ones. OK, there's the artery.
SPEAKER: Mm-hmm.
MONTGOMERY: Branch.
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BARBER: This is fascinating.
STEIN: Yeah, it was all very dramatic, you know, because as this was happening, the screen on the wall shows the helicopter approaching NYU Langone Health--
BARBER: Wow.
STEIN: --with the pig kidneys. The chopper swooped through the clear blue sky along the East River and sets down on the helipad. The arriving crew places a white box about the size of a microwave oven that contains the pig's two kidneys on a wheelchair and rushes it into the operating room.
BARBER: Wait, wait. So the organs arrive, like, during surgery?
STEIN: Exactly. While one team of surgeons was flying back with the pig kidneys, Robert Montgomery, the surgeon, and his team were preparing Towana to get the transplant. When the chopper arrived with the pig kidneys, they had both the left and right kidneys from the pig, just in case something went wrong with one.
BARBER: Wow.
STEIN: Robert removed them from their plastic bags and then meticulously started preparing one of them.
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MONTGOMERY: Let's sew this thing in.
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BARBER: Wow. And then they check to make sure, like, everything's working, right?
STEIN: Yeah, this is a big moment. They checked to see if blood from Towana's body is flowing into the pig kidney for the first time.
BARBER: Wow.
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MONTGOMERY: All right, so we're about to reperfuse. How's our blood pressure? You'll see it'll be kind of a little bit dark-colored initially. And now I'm taking the clamp off the artery.
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STEIN: And then it happened.
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MONTGOMERY: Oh, yeah.
[CELEBRATION]
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BARBER: Oh, thank goodness. Like, my heart's racing, and I'm just, like, hearing all this, like-- so the surgery was a success? Like, how's Towana doing now?
STEIN: Yeah, it was very dramatic. They then checked to make sure the kidney was doing its job, which was producing urine. And then she was discharged from the hospital less than two weeks after the surgery, which was earlier than they expected. And-- yeah, and then I went to her at an apartment where she's staying for, you know, probably about three months, not far from the hospital, so the doctors can keep an eye on her.
BARBER: OK.
STEIN: And I have to say, she is in amazing spirits. Most of the symptoms that had limited her before the surgery had disappeared.
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TOWANA LOONEY: No weakness, no tiredness, no fatigue, no swelling from fluid intake. I can eat more. I can drink more. I can walk a longer distance. It's just amazing.
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BARBER: Wow. Wow. That's amazing.
STEIN: Yeah, Towana says she'll never forget the first time she peed after the surgery. It was the first time she'd been able to do that in almost eight years.
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LOONEY: I was like, wow. I told the nurse I'm peeing. She said, no kidding. [LAUGHS] She said, you're peeing a lot, which is a good thing. That was exciting to me.
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BARBER: That is incredible.
STEIN: And she's really looking forward to spending more time with her daughters and grandchildren once she can go home and returning to her job as a cashier at Dollar General and activities she just couldn't do before.
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LOONEY: I just want to go shopping and not have to sit down. And I want to eat what I want to eat while I'm shopping. And I want to travel and stay more than three days. I ain't got to come back to dialysis. I ain't got to leave a day early to be at dialysis at 4:30 in the morning, 5 o'clock.
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BARBER: I am so happy for her. It seems like she's optimistic, and, like, her doctors are optimistic, too. But this procedure is still, like, very controversial, right?
STEIN: Oh, absolutely. You know, I talked to other scientists and bioethicists who said there's not a ton of scientific evidence to support these kinds of surgeries. Elsa Johnson is a bioethicist at SUNY Upstate Medical University in Syracuse. And she told me she's worried about the health of the pigs and about people getting these treatments. And she says the way it's happening now with individual experiments, all with different teams and protocols and organs and different genetic modifications, is not the best way to do science. Plus, she worries that these operations might be exploiting patients who are desperate for anything that could help them.
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ELSA JOHNSON: It's worrisome when patients do something because they believe it's going to save their life when we don't have good evidence that that will actually happen. And I worry about patients like that being exceptionally vulnerable and potentially exploited, even unintentionally, and just being exceptionally vulnerable to false hope in a situation where hope is, at this point, perhaps not warranted.
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STEIN: She's also concerned about the possibility of transmitting viruses from animals to patients, even something that could potentially be transmitted from person to person. The fear is another pandemic. In fact, everyone in the operating room that day, including me, is being tested to make sure we didn't catch a pig virus.
BARBER: Oh, that would be awful.
STEIN: Yeah, tell me about it. But on the other hand, patients like Towana are out of other options.
BARBER: Right, and given that, like, what do her doctors say about her chances for, like, long-term health? Will this kidney last her a long time?
STEIN: That's the big question. And, you know, Gina, we're in uncharted territory here. We just-- no one really knows what's going to happen. In fact, after being discharged early to an apartment near the hospital, Towana was back in the hospital for a few days because she had to get an additional anti-rejection drug.
BARBER: Oh, no.
STEIN: Yeah, that was a little worrisome. But her pig kidney is still working well, it seems. And doctors remain optimistic. And that's because, you know, she's a lot healthier than the other patients who had received other kinds of genetically modified organs before this. And also, even if this pig organ does fail, she still has the option to go back on dialysis, despite how unpleasant that would be. And, you know, Towana, who's very religious, says she's happy with the decision, despite what she's heard from some of her friends.
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LOONEY: I had one tell me, it's not in the Bible for us to receive human-- for a human to receive animal parts. I said, you ate bacon this morning for breakfast, didn't you? So [LAUGHS] it's life-saving.
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BARBER: Rob, thank you so much for bringing us this, like, incredible story. I hope you come back and, like, keep us updated.
STEIN: Oh, absolutely. I'll definitely be following this one.
BARBER: This episode was produced by Jessica Yung and Rachel Carlson. It was edited by our showrunner, Rebecca Ramirez, and Rob checked the facts. Patrick Murray was our audio engineer, Beth Donovan is our senior director, and Collin Campbell is our senior vice president of podcasting strategy. I'm Regina Barber. Thank you for listening to Short Wave from NPR.
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