Main Sequence

Main Sequence

Venture Capital and Private Equity Principals

Eveleigh, NSW 12,767 followers

Australia’s deep tech investment fund tackling the world’s biggest challenges

About us

We are Australia’s deep tech investment fund tackling the world’s biggest challenges by turning today’s scientific discoveries into tomorrow’s industries. Main Sequence works closely with scientists, researchers and industry collaborators to create, fund and accelerate new companies and industries that accelerate humanity for a more prosperous future. Main Sequence was set up in 2017 to manage the CSIRO Innovation Fund, founded by the Australian Government and the national science agency to reinvest its historic contributions into the successes of the future. Over the past four years, Main Sequence has invested in 39 companies changing the way healthcare is delivered, food is produced, spaces are connected and more. These investments have led to more than 60 company collaborative projects with universities and 19 projects with CSIRO.

Website
http://www.mseq.vc
Industry
Venture Capital and Private Equity Principals
Company size
11-50 employees
Headquarters
Eveleigh, NSW
Type
Partnership
Founded
2016
Specialties
Deep tech, Innovation, Venture capital, and Startups

Locations

Employees at Main Sequence

Updates

  • What does it take to build and scale an AI startup in today’s landscape? Our Investment Associate, Danielle Haj-Moussa, joins In The Blink of AI to unpack what investors are really looking for in AI startups, how scaling laws are shaping the future of the industry, and whether we’re in an AI bubble. Danielle also dives into:  🤖 The intersection of AI and robotics and its real-world applications. ⚡ How foundational AI models are reshaping industries. 🇦🇺 Why Australian founders are uniquely positioned to thrive in deep tech. 🎧 Plus, why so many deep-tech VCs are also DJs! A must-listen for founders, investors and anyone curious about where AI is headed. Tune in below. 👇 #DeepTech #AI #VentureCapital

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  • Two of our portfolio companies are teaming up to push the boundaries of space technology! 🚀 Advanced Navigation and Gilmour Space Technologies are joining forces as part of the Australian Space Agency’s Moon to Mars Initiative. This partnership will accelerate the development of Advanced Navigation’s high-shock Inertial Navigation System (INS)—designed to withstand the extreme forces of rocket launches—and support Gilmour Space’s Eris rockets and Elara satellite platforms in reaching Low Earth Orbit. This collaboration exemplifies what’s possible when #DeepTech companies work together to advance Australia’s sovereign aerospace capabilities. By combining cutting-edge navigation systems with innovative rocket technology, they’re paving the way for more resilient, cost-effective access to space for global customers. #SpaceTech #Innovation

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  • Our Principal Elaine Stead shared her insights on #healthtech trends in the latest State of Australian Startup Funding Report from Cut Through Venture. Here’s what we’ve learned: 🏥 There’s a notable rise in activity for 2024, with medtech deal flow outpacing biotech by 3:1—a reflection of Australia’s decades of strong capability in this space. 🌍 There’s a need for deeper capital to keep our brightest innovators onshore, especially at Series A/B stages. 📈 With the IPO window re-opening in the US and strong international interest, 2025 could mark a resurgence for healthtech startups. Read the full report to explore how the sector is evolving and where the opportunities lie. Link in comments. #DeepTech #Startups

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  • Welcome to our first newsletter of 2025, filled with Deep Tech Adventures! This is where we share the most exciting updates and insights from our team and portfolio for #founders, #researchers and #investors in the world of deep tech venturing. Take a read below for events on our radar, our most up-to-date ecosystem news and job opportunities calling your name. 👇

    Deep Tech Adventures with Main Sequence #16

    Deep Tech Adventures with Main Sequence #16

    Main Sequence on LinkedIn

  • Main Sequence reposted this

    Calling all founders, marketers and growth leaders—JDoodle is inviting beta testers to explore its latest prototype—an AI-powered web and app builder. This tool is built for those with bold ideas who want to move fast. Whether it’s: 🚧 Launching a product landing page. 🚧 Creating an app for your team. 🚧 Designing a micro-site for your next campaign. JDoodle’s platform empowers you to create with ease. Want to get involved? Sign up to beta test at doodle.new. Connect with Lucas Hakewill, Head of Growth at JDoodle to share your feedback and unlock free credits to bring your ideas to life. #DeepTech #AI #Innovation

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  • Calling all founders, marketers and growth leaders—JDoodle is inviting beta testers to explore its latest prototype—an AI-powered web and app builder. This tool is built for those with bold ideas who want to move fast. Whether it’s: 🚧 Launching a product landing page. 🚧 Creating an app for your team. 🚧 Designing a micro-site for your next campaign. JDoodle’s platform empowers you to create with ease. Want to get involved? Sign up to beta test at doodle.new. Connect with Lucas Hakewill, Head of Growth at JDoodle to share your feedback and unlock free credits to bring your ideas to life. #DeepTech #AI #Innovation

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  • The food tech sector is experiencing a “funding winter,” but as James Petrie, CEO of Nourish Ingredients points out, this correction isn’t the end—it’s the beginning of a more resilient & focused industry. 🌱 In his piece, James breaks down why the transformation of our food system is inevitable and highlights the shift investors are making toward tangible market opportunities. Here are some key takeaways: 🍔 Resetting expectations: The days of capital-intensive promises are over. The new focus? Proven pathways to revenue, strategic partnerships, and commercial adoption. 🌍 Existential drivers: Climate change, resource constraints, and vulnerabilities in traditional food systems are accelerating the need for food tech solutions. 🔬 Deep tech solutions: Hybrid foods, underpinned by scalable, climate-resilient supply chains, present massive market opportunities. At Nourish Ingredients, the team is meeting these challenges head-on—developing solutions that enhance taste and functionality, while building strong commercial relationships from day one. Read the full op-ed to explore how food tech can navigate this reset and emerge stronger. 👇 #FoodTech #DeepTech #Sustainability

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  • Presien has been selected for the prestigious 2025 John Deere Collaborator Program, an initiative connecting trailblazing startups with one of the world’s leading innovators in agricultural, construction, and forestry equipment. Presien’s cutting-edge AI solutions have been honed for over nearly a decade in on-machine sensing, computer vision, and machine learning. Below you can see a Presien computer vision system fitted onto a truck to improve site safety, efficiency and operations. Congratulations to CEO Mark Richards and the Presien team on this incredible milestone—opening the doors to expand its impact and deliver smarter, safer solutions to teams around the globe. #DeepTech #AI #ConstructionTech

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  • Amber Electric has acquired Charge HQ, a smart EV charging platform helping Australians optimise charging for cost savings and renewable energy use. 🚗⚡ By integrating Charge HQ’s solar-first technology with Amber Electric’s real-time wholesale pricing, this partnership empowers EV owners to: 🔋Charge directly from rooftop solar.  💸 Reduce costs with smarter scheduling.  🌍 Maximise renewable energy usage. This milestone strengthens Amber Electric’s leadership in the energy transition and aligns with its advancements in vehicle-to-grid technology—shaping a smarter, more sustainable energy future for Australia. #ClimateTech #RenewableEnergy #Innovation

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  • We’re constantly seeking breakthrough solutions that address humanity’s greatest challenges. When it comes to critical minerals, the energy transition depends on scalable, sustainable innovation. Enter ElectraLith. 🌍🔋 Its single-step, electrochemical Direct Lithium Extraction solution is a game-changer, here’s why: ⚡ Modular, cost-efficient, and scalable design. 🌱 Cleaner and more sustainable than traditional methods. 🌍 Applicable across a wide range of lithium resources. Under the leadership of CEO Charlie McGill, CTO SJ Oosthuizen, and VP of Engineering Damien Edwards, ElectraLith is scaling its technology to meet global demand and fuel the energy transition. Our investment Manager, Jun Qu recently took the pen to share our investment story with ElectraLith, read more in the comments. #Lithium #ClimateTech #Energy

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