TowardPi

Regulatory mechanism of the circadian rhythm on CNV revealed by full range SS-OCTA！ Research recently published in < Biochemistry and Molecular Biology > investigated the regulatory mechanism of STRA6 in CNV under circadian rhythm disturbances via in vivo and in vitro animal study by using full range SS-OCTA. This study represented the first attempt to establish a connection between circadian rhythms and AMD. A circadian rhythm in VEGF expression was noted in this study that disturbed circadian rhythm might lead to a decrease during physiological conditions. STRA6 knockdown effectively mitigated the CNV promotion effect of circadian rhythm disturbance in mice and cell models. In vitro evidences suggested that STRA6 reduced CNV production by inhibiting JAK2/STAT3 phosphorylation after circadian rhythm disturbance. “All these results suggest that STRA6 may be a new direction for the treatment of AMD.” A 400kHz speed swept source OCTA (#BMizar, TowardPi Medical) was used in this study to achieve OCT and OCTA images of mice. No additional lens is needed to capture animal eyes. The thickness, area and blood flow of CNV lesion were automatically quantified with built-in software on the device. This research is authored by Dr. Ying Yang, Dr. Shenglai Zhang, etc. team of Prof. Jia Chen and Prof. Aimin Sang, from Affiliated Hospital of Nantong University. Link to full text: https://lnkd.in/gjqMnHjE #ophthalmology #SSOCT #medicaldevices  

TowardPi proudly presents our year-end sales report. 510+ OCT installation domestically plus 60+ outside China since our CE approval in the second half of this year. Our official international orders covered 23 countries and regions, they are: Greece, Guatemala, Singapore, Hong Kong, Switzerland, Türkiye, Mexico, Japan, Argentina, Spain, Netherlands, Italy, France, Australia, United Kingdom, Austria, Slovakia, Malaysia, Chile, Colombia, Venezuela, Kazakhstan, Peru. * Statistics are as of December 2024 (OCT products only) Non-formal orders (research cooperation, leasing & loaning, deferred payment, donation, temporary exhibition) are not included in oversea orders.   There are also 38 countries with confirmed distributors to be commercialized soon: Albania, Algeria, Bahrain, Bolivia, Bosnia Herzegovina, Bulgaria, Caribbean Islands, Croatia, Costa Rica, Cyprus, Czech Republic, Dominican Republic, Ecuador, Egypt, El Salvador, Honduras, India, Indonesia, Iraq, Ireland, Kosovo, Lebanon, Libya, Moldova, Montenegro, New Zealand, Nicaragua, North Macedonia, Panama, Paraguay, Poland, Romania, San Marino, Saudi Arabia, Serbia, Slovenia, Thailand, Uruguay, Vatican City. More countries are open for distribution, welcome to contact info@towardpi.com (Please send profile through company domain email boxes. No reply to public mailboxes for distribution issues.)   Sincerely thank our users and partners ❤️ and look forward to a fruitful 2025. Happy New Year 🎉 ! Accuvision; Acuarius Optical; ADBOS - Medical Solutions GmbH; ALBASAR FOR MEDICAL SUPPLIES CO.; Alfa Instruments srl; Alfa Intes Industria Terapeutica Splendore; Andrec; Berli Jucker Public Company Limited (BJC); CMI Slovakia & Czech Republic; EBC EUROPE; EYECO; İ-Tek Medikal; Insight Medical Supplies Co.; Laméris; Mainline Instruments; Mandarin Opto-Medic Co Pte Ltd; OCULUS Brasil; OCULUS Iberia; OMNI SRL ; Ophtalcom C.A; OPHTALMIC DEVICE; Optohellas; VISAVI - Instruments Suisses;  Spectrum Uruguay, etc.

An intraocular “secret eye” revealed by UWF SS-OCT! Case report recently published in <JAMA Ophthalmology> described a case of retinal detachment with a large retinal cystoid abnormality. A 400kHz speed full range swept source OCTA (#BMizar, TowardPi Medical) was used in this case to easily achieve the high-resolution B-scan image of the detached peripheral retina. No retinal hole was found in this case. This case is authored by Dr. Yue Zhang and Dr. Qiang Liu, team of Prof. Xiaobing Yu, from Beijing Hospital. Original text link: https://lnkd.in/gssP7rec #ophthalmology #SSOCT #medicaldevices

Retinal vein anastomoses revealed by UWF SS-OCTA！ The case report recently published in <Ophthalmology> described a patient with retinal venous-venous anastomoses associated with persistent high IOP. A 400kHz speed full range swept source OCTA (#BMizar, TowardPi Medical) was used in this case to acquire high-resolution 24mm x 20mm UWF OCTA image of the abnormal vein anastomoses. 24mm UWF high-resolution B-scans were captured to follow up the change of choroidal thickness after treatment. This case is authored by Dr. Nan Luo, Dr. Yuzhou Xiang, team of Prof. Jingjing Huang from Zhongshan Ophthalmic Center, Sun Yat-sen University. Original text link: https://lnkd.in/gvBExJ_G #ophthalmology #SSOCT #medicaldevices

Peripapillary Capillaries Changes in Myopia revealed by UWF full range SS-OCTA！ Research recently published in <Translational Vision Science & Technology> explored the effect of high myopia on peripapillary capillaries (RPCs) by using UWF full range SS-OCTA and analyzing superficial retina vascular density (SVD). By detecting the changes in peripheral SVD and the area of RPC, the results showed that high myopic individuals had significantly lower peripheral SVD and a smaller area of RPC corresponding to axial length and diopter. Early detecting the peripheral vasculature and structure might be beneficial in identifying some early changes in high myopia. And the area of RPC was proposed as a new biomarker for monitoring the progress of myopia. A 400kHz speed swept source OCTA (#BMizar, TowardPi Medical) was used in this study to achieve high-resolution 120° UWF OCTA images which can be used to detect peripheral retinal changes. Numerous vascular parameters, such as SVD, can be quantified in all sizes OCTA images with built-in software. This research is authored by Dr. Yishuang Xu, team of Prof. Zhen Chen and Prof. Dihao Hua, from Renmin Hospital of Wuhan University. Link to full text: https://lnkd.in/ggmft6t9 #ophthalmology #SSOCT #medicaldevices

Vortex vein drainage systems in healthy individuals imaged by UWF full range SS-OCTA！ New research recently published in <Translational Vision Science & Technology> investigated the choroidal characteristics of vortex vein (VV) drainage systems in healthy individuals by using ultra-widefield full range SS-OCTA. According to the results, one of the most significant characterizations of the VV drainage system identified was the superotemporal drainage system emerging as the preferential system in healthy eyes. The sex differences on perfusion in the VV drainage system was obvious. Higher CVI was observed for men compared to women. The occurrence of intervortex venous anastomosis, which is a common feature of pachychoroid spectrum disorders, was observed to be most frequent in the temporal quadrant. “The VV drainage system may be considered a promising biomarker for ocular diseases.” A 400kHz speed swept source OCTA (#BMizar, TowardPi Medical) was used in this study to achieve 24mmx20mm choroid OCTA with built-in AI-assisted algorithm. Five 24mmx20mm images can be intelligently montaged into a UWF choroid image (>200 degrees) automatically to visualize complete vortex vein ampullas in four quadrants. Quantification parameters of choroid OCTA, such as 3D-CVI, have high repeatability and accuracy based on precise segmentation algorithm. This research is authored by Dr. Zhonghua Luo, Dr. Xiaomei Xiong, Dr. Shengsong Huang, etc. team of Prof. Xiaoling Liang and Prof. Shanshan Yu, from Zhongshan Ophthalmic Center, Sun Yat-Sen University. Link to full text: https://lnkd.in/gQpxHTH3 #ophthalmology #SSOCT #medicaldevices

A new round of advanced service training for Alfa Instruments srl (Italy), and EYECO (Mexico) has successfully completed in TowardPi Shanghai office today. Sales is just the start, maintenance and service is the guarantee. Next round training, January 2025.

While booths were still being built around us, TowardPi welcomed the first batch of visitors. When the conference was over and the surroundings were empty, TowardPi were still introducing the OCTs. Early morning symposium before sunrise, images being presented in the main hall program, crowded exhibition booth at FLORetina/ICOOR… What supports the TowardPi’s growing strength? Our technology⚛️, and the love❤️ of our dearest users and global partners.

Posterior Gaussian curvature -- brand new parameter assessing retinoschisis in high myopia by UWF-SS-OCT! Research recently published in <American Journal of Ophthalmology> evaluated macular retinoschisis and paravascular retinoschisis in high myopia and the relationship between existence of retinoschisis and posterior Gaussian curvature (K) by using UWF full Range SS-OCTA, authored by Dr. Qing Zhao, etc. team of Prof. Zhikun Yang, from Peking Union Medical College Hospital. The results showed that the largest Gaussian curvature was predominantly found in the posterior pole. Macular retinoschisis and higher maximum curvature value were significantly associated with the presence of paravascular retinoschisis. Longer axial length and higher Gaussian curvature could be high risk factors of whole retinoschisis. 'UWF-SS-OCT holds promise as an imaging technique for the early detection of extrafoveal retinoschisis.' A 400kHz speed full range swept source OCTA (#BMizar, TowardPi Medical) was used in this research to quantify the posterior Gaussian curvature (K) with built-in software on the device based on UWF 3D structural reconstruction. Original text link: https://lnkd.in/gRv2v44A #ophthalmology #SSOCT #medicaldevices

7AM, December, Florence. Zero degrees Celsius, 35 minutes before sunrise. The only morning symposium in FLORetina. The congress program wouldn’t start in one and a half hour. An ultimate test of young TowardPi's influence who was just CE cleared in Europe a few months ago. Yet, our meeting room was packed! Nothing can stop the enthusiasm from learning advanced ophthalmic OCT technology. Huge thanks to our prestigious speakers and honorable guests. Lecturers: Dr. Ali ERGINAY (France), Dr. Andrea Govetto (Italy), Dr. Belkacem HAOUCHINE (France), Dr. Tommaso Rossi (Italy), and Dr. Jian Zhou (China)