Dynamic42 GmbH

👏 To our amazing customers: Your groundbreaking research using our organ-on-chip platforms continues to inspire us! From personalized medicine breakthroughs to reducing animal testing, you're changing the face of drug development. We've highlighted some of your achievements in our year-end blog: https://lnkd.in/eqYs-8jz 🥂 Here's to more innovation in 2025!

We are curious! Which type of spheroid or organoids are you currently work with or would like to work with? Let us know and we will share the results in 1 week.

🥁 Drum roll.... And the lucky winner of our St. Nikolas 🎅 draw is: 🌟 Jelena Budimir 🌟 Congratulations to you and we will be in touch shortly.

From ornithology to biochemistry.   His love for biology and interest for laboratory technology was always a strong driver for Martin Raasch. The Federal Network 3R spoke to our CEO and Co-founder and found out about his path with Dynamic42 GmbH and his vision for the future.   Learn about our breakthroughs in lung, liver, and gut models, the challenges of integrating complex organ systems, and Martin’s vision for societal impact through science.   Dive deeper into his journey and the future of biotechnology here: https://shorturl.at/BG4Ra (Article in German only)   Image source: BMBF / Laurin Schmid / Bundesfoto

Our spheroid-on-chip technology in action This video contains a summary, of our project with Prof. Dr. Nicole Teusch and Alina Deipenbrock from the University of Düsseldorf, about the development of an immune competent PDAC biochip model for preclinical testing. Within this project, we have a developed an innovative biochip with three culture chambers. This biochip enables the cultivation of complex, three-dimensional tissue cultures and opens up the possibility of cultivating spheroids and stem cell-based organoids in one chip platform and to combine them with other tissue components, such as blood vessel tissue. In this video they explain their research on identifying fungi which are a rich source of potential active substances and what methods are being used to test the identified substances in their laboratory. Watch it here: https://lnkd.in/eu4Crfca

Didn't find a chip in your boot for St. Nicholas? No worries, we are giving away a FREE DynamicOrgan Developer Kit!   As a small Christmas gift, we are giving away a FREE DynamicOrgan Developer Kit (small) to a lucky winner of our draw. Here is how:   1. Follow our page. 2. Like this post. 3. Comment tagging someone who might like the kit as well. 4. Visit https://shorturl.at/kSHtj to learn more about the details and T&C of this draw.   The final winner will be drawn and announced on December the 12th, 2024. If you are the lucky winner, our staff will contact, you for further details soon after the draw.

Novel therapies are needed for Pancreatic ductal adenocarcinoma (PDAC). #PDAC is among the deadliest solid malignancies, with a five-year survival rate of less than 10%. Classically, drug screenings were performed on cultured pancreatic #tumor cells. However, such 2D-models showed limited translation relevance as they fail to recapitulate the cellular heterogeneity, structural complexity, and vascularization of PDAC tumors. We are developing a three-channel micro cavity-equipped microfluidic #biochip to generate patient-derived pancreatic cancer spheroid-on-a-chip models for screening novel therapeutic approaches. Here is a summary of the current outcome of this project: / The Dynamic42 3-chamber biochip allows controlled spatially separated coculture of spheroids and endothelial cells / PDAC spheroids in combination with perfusion strongly impact endothelial cell fitness / Integration of a CAF barrier promotes survival of the endothelial cell layer / We are now using this system to screen for novel PDAC therapeutics that are administered through the vasculature

Registration live! Be quick to secure 1 of only 6 slots in this course!   3-day Advanced Course “Cancer and Immune Cell Integration”   Within our #Dynamic42Academy we are now offering an advanced course where you can learn how to set up cancer and immune cell interaction on a biochip using organ-on-chip technology. Because cancer cells do not live on a plate! They are suspended in a 3D matrix where they interact with immune cells, fibroblasts and the vascular network. Organ-on-chip technology allows us to recreate this complex tumor microenvironment.   Here is what we will teach you in this 3-day course:   / Basic handling techniques of the Dynamic42 biochip / Integrate spheroids in a perfused vascular network within the biochip / Practice to embed and grow tumor structures in a 3D hydrogel inside a biochip / Observe immune cell invasion into a tumor via life imaging / Monitor how perfusion impacts all of these effects   When:   20 – 22. May 2025

New research alliance Together with Universitätsklinikum Jena we are working on the development of a stem cell-based liver model (Vascu Chip). The result will be a biochip-based model for personalized drug testing. The network is funded by the Thüringer Aufbaubank with #EU and #EFRE funds (FTI, Project nb. 2024 VFE 0050).   Our scientist, Joanna Nowacka will be working on the vascularized liver-on-chip model for personalized compound testing. Within her work, Joanna will be developing stem cell cultures, from which she can then differentiate multiple cell types.   Joanna says: “I believe organ-on-chip technology represents the future of drug testing models. I am eager to join Dynamic42 to contribute my stem cell expertise to their already remarkable platforms.”

Neuer Forschungsverbund Vascu Chip: Gemeinsam mit Dynamic42 GmbH arbeiten wir an der Entwicklung eines stammzellbasierten Lebermodells. Entstehen soll ein #Biochip zur personalisierten Wirkstofftestung. Der Verbund wird von der Thüringer Aufbaubank mit #EU- und #EFRE-Mitteln gefördert. https://lnkd.in/eExe2uD4