Epigene Labs

Exploring New Frontiers in Multi-Omics Research at the HADACA Challenge Two weeks ago, two of our talented computational biologists (Solène Weill and Guillaume Appé) participated in the 3rd edition of the Health Data Challenge, diving deep into the complex world of multi-omics cell-type deconvolution in #CancerResearch. 🏔️ In the heart of Aussois's mountains, this event offered an incredible blend of scientific talks, technical challenges, collaborative writing sessions, and even mountain hikes! Many thanks to the organizing committees led by Magali Richard, Yuna Blum, and Anaïs Baudot for creating such a dynamic and enriching experience. 🔬 At Epigene Labs, we are committed to unlocking the potential of secondary data analysis in multi-omics research. Cell-type deconvolution is a key tool in gaining new insights from existing bulk omic #data, especially when integrated with cutting-edge single-cell data capabilities. 💡 This event was also the perfect opportunity to introduce our open-source Python package InMoose to the #bioinformatics community. We learned a lot about the challenges and opportunities in French academic research and explored ways Epigene Labs can contribute even more meaningfully to advancing #cancer research.

Thank you to France Biotech and the "AI & Biodiscovery" expert group for publishing this insightful mapping of business models in the TechBio sector. 👏 Studies like this help us better understand the evolution of the TechBio ecosystem in France 🇫🇷, highlighting key trends and opportunities shaping the future of AI-powered drug discovery.

We’re thrilled to announce that our CEO, Akpeli Nordor, and our VP of Business Development, Kevin Cho, will be representing Epigene Labs at the J.P. Morgan Healthcare Conference 2025 in San Francisco! 🙌

[ENG] Cancer: a disease with a global cost beyond imagination. Can you guess how much? 💸 Spoiler: it’s more than you think! The estimated global economic burden of #cancers from 2020 to 2050 is $𝟮𝟱.𝟮 𝘁𝗿𝗶𝗹𝗹𝗶𝗼𝗻 based on research published by Chen et al. in 2023. This staggering figure represents far more than medical expenses; it encompasses a range of direct, indirect, and intangible costs: 1️⃣ 𝗗𝗶𝗿𝗲𝗰𝘁 𝗰𝗼𝘀𝘁𝘀: Modern cancer treatments are among the most expensive, with medications reaching thousands of dollars per month, not to mention hospital stays, follow-ups, and palliative care. 2️⃣ 𝗜𝗻𝗱𝗶𝗿𝗲𝗰𝘁 𝗰𝗼𝘀𝘁𝘀: Productivity losses also weigh heavily. Patients and caregivers take time off work, leading to reduced income, while financial aid and disability pensions increase social spending. 3️⃣ 𝗜𝗻𝘁𝗮𝗻𝗴𝗶𝗯𝗹𝗲 𝗰𝗼𝘀𝘁𝘀: Physical and emotional suffering for patients and their families, which is difficult to quantify but just as real. Beyond this staggering cost lies an equally profound but often overlooked burden: the 𝗵𝘂𝗺𝗮𝗻 𝗮𝗻𝗱 𝗲𝗺𝗼𝘁𝗶𝗼𝗻𝗮𝗹 𝘁𝗼𝗹𝗹. 👫 Cancer doesn’t just impact economies; it reshapes lives. Families face immense physical, psychological, and emotional challenges, from the stress of navigating treatments to the pain of supporting loved ones through uncertainty. ---------------------------------------------------------------------------- [FR] Le cancer : une maladie dont le coût mondial dépasse l’imaginable. Pouvez-vous deviner combien ? 💸 Spoiler : c’est bien plus que ce que vous pensez ! L'estimation du coût économique mondial des cancers pour la période de 2020 à 2050 est de 25,2 trillions de dollars, selon une étude publiée par Chen et al. en 2023. Ce chiffre vertigineux ne se limite pas aux frais médicaux ; il englobe un large éventail de coûts directs, indirects et intangibles : 1️⃣ 𝗖𝗼𝘂̂𝘁𝘀 𝗱𝗶𝗿𝗲𝗰𝘁𝘀: Les traitements modernes contre le cancer figurent parmi les plus coûteux, avec des médicaments atteignant des milliers de dollars par mois, sans compter les séjours à l’hôpital, les suivis et les soins palliatifs. 2️⃣ 𝗖𝗼𝘂̂𝘁𝘀 𝗶𝗻𝗱𝗶𝗿𝗲𝗰𝘁𝘀: Les pertes de productivité pèsent également lourdement. Les patients et leurs aidants doivent souvent s’absenter du travail, entraînant une diminution des revenus, tandis que les aides financières et les pensions d’invalidité augmentent les dépenses sociales. 3️⃣ 𝗖𝗼𝘂̂𝘁𝘀 𝗶𝗻𝘁𝗮𝗻𝗴𝗶𝗯𝗹𝗲𝘀: Souffrances physiques et psychologiques pour les patients et leurs familles, difficilement chiffrables mais tout aussi réelles. Au-delà de ce coût faramineux se cache un autre fardeau tout aussi profond mais souvent négligé : l’impact humain et émotionnel. 👫 Le cancer n’impacte pas seulement les économies ; il bouleverse des vies. Les familles affrontent d’immenses défis physiques, psychologiques et émotionnels, entre le stress lié aux traitements et la douleur de soutenir leurs proches dans l’incertitude.

𝗜𝘁’𝘀 𝗵𝗲𝗿𝗲. 𝗜𝘁’𝘀 𝗽𝗼𝘄𝗲𝗿𝗳𝘂𝗹. 𝗔𝗻𝗱 𝗶𝘁’𝘀 𝗮𝗹𝗿𝗲𝗮𝗱𝘆 𝗺𝗮𝗸𝗶𝗻𝗴 𝘄𝗮𝘃𝗲𝘀 𝗶𝗻 𝗼𝗻𝗰𝗼𝗹𝗼𝗴𝘆 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵. 𝗠𝗲𝗲𝘁 𝗜𝗻𝗠𝗼𝗼𝘀𝗲 🫎, 𝘆𝗼𝘂𝗿 𝗻𝗲𝘄 𝗴𝗼-𝘁𝗼 𝗣𝘆𝘁𝗵𝗼𝗻 𝗲𝗻𝘃𝗶𝗿𝗼𝗻𝗺𝗲𝗻𝘁 𝗳𝗼𝗿 𝗯𝗶𝗼𝗶𝗻𝗳𝗼𝗿𝗺𝗮𝘁𝗶𝗰𝘀! At Epigene Labs, we developed InMoose, an open-source #Python package that revolutionizes large-scale #transcriptomic analysis. 📊 ➡️ Why was InMoose created? What are its key features? In which fields is it already being used? And why is it particularly relevant for pharma groups and oncology industries? We answer all these questions in our carousel! 👇 🌟 Downloaded over 30,000 times, InMoose simplifies the transition from R to Python while maintaining the precision and performance of the best bioinformatics tools. If you work in #oncology research or the #pharma industry, discover how InMoose can accelerate your projects. Find more details in our preprint article, and access the InMoose tool via the links in the comments below. Give InMoose a try and let us know your feedback!

[ENG] 💭 𝗗𝗿𝗲𝗮𝗺𝗶𝗻𝗴 𝗼𝗳 𝗮 𝗿𝗼𝗹𝗲 𝘄𝗵𝗲𝗿𝗲 𝘆𝗼𝘂𝗿 𝘄𝗼𝗿𝗸 𝗱𝗿𝗶𝘃𝗲𝘀 𝗿𝗲𝗮𝗹 𝗰𝗵𝗮𝗻𝗴𝗲? You’re not alone—we’re building a team of changemakers just like you! 🫵 At Epigene Labs, we accelerate the discovery of life-saving treatments through cutting-edge #technology and interdisciplinary collaboration. And we’re looking for passionate individuals to join our mission! 🎯 𝗢𝗽𝗲𝗻 𝗣𝗼𝘀𝗶𝘁𝗶𝗼𝗻𝘀: ➡️ Senior/Lead AI Researcher (full-time) ➡️ Front-End Development (internship) ➡️ Product Management (internship) ➡️ Computational Biology (internship) ➡️ Data Science (internship) 💡 𝗪𝗵𝘆 𝘄𝗼𝗿𝗸 𝘄𝗶𝘁𝗵 𝘂𝘀? - Contribute to impactful #CancerResearch. - Collaborate with a dynamic, remote-friendly team based in Paris and Boston. - Be part of a human-centered mission where your skills drive real change. ✨ 𝗖𝘂𝗿𝗶𝗼𝘂𝘀 𝗮𝗯𝗼𝘂𝘁 𝘄𝗵𝗮𝘁 𝗶𝘁’𝘀 𝗹𝗶𝗸𝗲 𝘁𝗼 𝘄𝗼𝗿𝗸 𝗮𝘁 𝗘𝗽𝗶𝗴𝗲𝗻𝗲 𝗟𝗮𝗯𝘀?—Meet Solène Weill, who started as a Computational Biologist, grew into the role of Senior Computational Biologist, and is now our Lead Computational Biologist 🚀! 👉 Apply today and let’s work together to accelerate cancer #treatmentdiscovery! 📩 Check out the details and apply on our Welcome to the Jungle page (link in the comments). ---------------------------------------------------------------------------- [FR] 💭 𝗩𝗼𝘂𝘀 𝗿𝗲̂𝘃𝗲𝘇 𝗱’𝘂𝗻 𝗿𝗼̂𝗹𝗲 𝗼𝘂̀ 𝘃𝗼𝘁𝗿𝗲 𝘁𝗿𝗮𝘃𝗮𝗶𝗹 𝗮 𝘂𝗻 𝗿𝗲́𝗲𝗹 𝗶𝗺𝗽𝗮𝗰𝘁 ? Vous n’êtes pas seul·e, nous construisons une équipe de visionnaires comme vous ! 🫵 Chez Epigene Labs, nous accélérons la découverte de traitements qui sauvent des vies grâce à des technologies de pointe et une collaboration interdisciplinaire. Et nous recherchons des personnes passionnées pour rejoindre notre mission ! 🎯  𝗣𝗼𝘀𝘁𝗲𝘀 𝗼𝘂𝘃𝗲𝗿𝘁𝘀 : ➡️ Senior/Lead AI Researcher (CDI) ➡️ Développement Front-End (stage) ➡️ Product Management (stage) ➡️ Biologie Computationnelle (stage) ➡️ Data Science (stage) 💡 𝗣𝗼𝘂𝗿𝗾𝘂𝗼𝗶 𝗻𝗼𝘂𝘀 𝗿𝗲𝗷𝗼𝗶𝗻𝗱𝗿𝗲 ? - Contribuez au progrès de la recherche contre le cancer - Collaborez avec une équipe dynamique et flexible en télétravail, basée à Paris et Boston - Faites partie d’une mission centrée sur l’humain où vos compétences font vraiment la différence ✨ 𝗩𝗼𝘂𝘀 𝘃𝗼𝘂𝘀 𝗱𝗲𝗺𝗮𝗻𝗱𝗲𝘇 𝗮̀ 𝗾𝘂𝗼𝗶 𝗿𝗲𝘀𝘀𝗲𝗺𝗯𝗹𝗲 𝗹𝗮 𝘃𝗶𝗲 𝗰𝗵𝗲𝘇 𝗘𝗽𝗶𝗴𝗲𝗻𝗲 𝗟𝗮𝗯𝘀 ?Découvrez Solène Weill , qui a commencé en tant que Computational Biologist, a évolué vers le poste de Senior Computational Biologist et est aujourd’hui notre Lead Computational Biologist 🚀! 👉 𝗣𝗼𝘀𝘁𝘂𝗹𝗲𝘇 𝗱𝗲̀𝘀 𝗮𝘂𝗷𝗼𝘂𝗿𝗱’𝗵𝘂𝗶 et travaillons ensemble pour accélérer la découverte de traitements contre le #cancer ! 📩 Retrouvez tous les détails et postulez sur notre page Welcome to the Jungle France (lien en commentaire).

Akpeli Nordor, our CEO, had the pleasure of connecting with innovators and investors at the Majycc Innovation Santé - UI Investissement meetup at Google in Paris! 🚀 Together, we're exploring how #AI and collaboration can drive transformative breakthroughs in #healthcare. 💡

𝗧𝗵𝗶𝘀 #𝗠𝗼𝘃𝗲𝗺𝗯𝗲𝗿, 𝗮 𝗠𝘂𝘀𝘁𝗮𝗰𝗵𝗲 𝗜𝘀𝗻’𝘁 𝗘𝗻𝗼𝘂𝗴𝗵 ❌ —𝗟𝗲𝘁’𝘀 𝗧𝗮𝗸𝗲 𝗔𝗰𝘁𝗶𝗼𝗻 𝗳𝗼𝗿 𝗠𝗲𝗻’𝘀 𝗛𝗲𝗮𝗹𝘁𝗵! This November, we want to highlight a cause close to our hearts: raising awareness and advancing research on male cancers, such as prostate and testicular cancer, as well as #MentalHealth. 🔬 𝗞𝗲𝘆 𝗳𝗮𝗰𝘁𝘀: - Prostate cancer is the most commonly diagnosed cancer in men, with approximately 1.6 million new cases and 366,000 deaths reported each year. (Pernar et al., 2018) - Testicular cancer is the most common malignant tumor among men aged 14 to 44, with its incidence steadily increasing in Western countries over the last 20 years. Its development is influenced by both genetic predispositions and environmental factors, with cryptorchidism identified as the primary risk factor. (Cheng et al., 2018) - A global study on #COVID19 trends and impacts revealed that 36.8% of men experience #depression and 33.8% face #anxiety, yet men are less likely than women to seek help for mental health concerns, making these issues harder to detect (Gottert et al., 2022). ✨ 𝗢𝘂𝗿 𝗰𝗼𝗺𝗺𝗶𝘁𝗺𝗲𝗻𝘁: At Epigene Labs, we contribute to accelerating research and making treatments more accessible. Because every breakthrough can save lives. 👉 𝗛𝗼𝘄 𝗰𝗮𝗻 𝘆𝗼𝘂 𝗷𝗼𝗶𝗻 𝘁𝗵𝗲 𝗺𝗼𝘃𝗲𝗺𝗲𝗻𝘁? - Get screened. - Share information. - Support research initiatives. Together, let’s advance #MensHealth. 💙 (Yes, you guessed it—these are indeed the mustaches of our very own team members! 😎)

[𝗘𝗡𝗚] 🧐 Did you know how #cancer treatments have evolved? From surgery to targeted and #immunotherapies, each step has saved lives and pushed the boundaries of #medicine. Discover this fascinating journey toward increasingly precise and effective treatments! 1️⃣ Surgery 2️⃣ Radiation Therapy 3️⃣ Chemotherapy 4️⃣ Targeted Therapy 5️⃣ Immunotherapy Today, research is advancing faster than ever to offer patients personalized options. 🔬 Click to explore each breakthrough! And what about the future? 🤖✨ With innovations like #nanorobots capable of targeting cancer cells at the molecular level, we are on the verge of even more groundbreaking treatments. Which future technology will have the biggest impact on cancer treatment? Share your thoughts! 👇🏻 ----------------------------------------------------------------------- [𝗙𝗥] 🧐 Saviez-vous comment les traitements contre le cancer ont évolué ? De la chirurgie aux thérapies ciblées et à l'#immunothérapie, chaque étape a sauvé des vies et repoussé les limites de la #médecine. Découvrez ce parcours fascinant vers des traitements de plus en plus précis et efficaces ! 1️⃣ Chirurgie 2️⃣ Radiothérapie 3️⃣ Chimiothérapie 4️⃣ Thérapie Ciblée 5️⃣ Immunothérapie Aujourd'hui, la recherche progresse plus vite que jamais pour offrir aux patients des options personnalisées. 🔬Cliquez pour explorer chaque avancée ! Qu'en est-il du futur ? 🤖✨ Avec des innovations comme des nanorobots capables de cibler les cellules cancéreuses au niveau moléculaire, nous sommes à l'aube de traitements encore plus révolutionnaires. Selon vous, quelle technologie future aura le plus grand impact sur le traitement du cancer ? Partagez vos idées ! 👇🏻

𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝘃𝗲 𝗶𝗱𝗲𝗮𝘀, 𝗻𝗲𝘄 𝗰𝗼𝗻𝗻𝗲𝗰𝘁𝗶𝗼𝗻𝘀, 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗹𝗮𝘁𝗲𝘀𝘁 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗶𝗻 #oncology 𝗥&𝗗 𝗮𝗻𝗱 𝗯𝘂𝘀𝗶𝗻𝗲𝘀𝘀 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁—#BioEurope 𝗵𝗮𝗱 𝗶𝘁 𝗮𝗹𝗹!🌟 It is truly an exciting time for #biotech and #pharma, with constant waves of innovative platforms and pioneering technologies emerging in oncology and across the therapeutic landscape. It was inspiring to dive into new types of modalities and witness the cross-pollination of these advancements. 🚀 A huge thank you to everyone who took the time to meet us and share ideas. Let’s keep the conversation going - together, we can drive the future of #cancer treatment forward! 🤝