Humanitas Research

🎉 We are proud to share that two Humanitas researchers – Simona Lodato and Marianna Leonzino – are among the recipients of Fondazione Telethon’s multi-round grant. 🔬 Lodato Simona is exploring how mutations in the CXCR4 gene disrupt brain development in WHIM syndrome, aiming to uncover new therapeutic possibilities. 🔬 marianna leonzino is investigating VPS13D gene mutations and their impact on mitochondrial function in neurodevelopmental disorders, paving the way for novel treatments. Their work highlights the power of fundamental research in driving breakthroughs for rare diseases. A huge thanks to Fondazione Telethon for supporting these impactful projects! Together, we are bringing science closer to hope 💚 #HumanitasResearch #Hunimed #RareDiseases #ResearchInnovation

🗣️ On Monday, we had the honour of hosting Prof. #MarinoZerial – Group Leader and Scientific Director at Human Technopole, who shared groundbreaking insights into the interplay between cellular trafficking mechanisms and the biophysics of #liver tissue formation. His presentation not only captivated our audience of researchers and physician scientists, but also fuelled a dynamic discussion that highlighted the importance of collaboration in advancing scientific knowledge. Thank you, Prof. Zerial, for inspiring us all! 🙌💡 Luigi Maria Terracciano Michela Matteoli Maria Rescigno #AlbertoMantovani #HumanitasResearch #Hunimed #Biophysics #SeminarSeries

🔬 According to a new study conducted in the laboratories at Humanitas Research, the progression of heart failure is driven by an autoimmune reaction: the discovery could open up new strategies to treat one of the most common cardiovascular diseases. The study, published in Circulation Research was led by Prof. Marinos Kallikourdis – Group Leader of the Adaptive Immunity Lab, with Prof. Gianluigi Condorelli – Director of the Research Program in Cardiovascular Medicine and Head of the Cardio Center at Humanitas Research Hospital. Among the first authors Marco Cremonesi, Arianna Felicetta and Elisa Martini. The researchers identified several molecules, produced by the stressed heart, that initiate the autoimmune response and used them to create a prototype tolerising vaccine. Tested in an experimental model of the disease, the vaccine was able to dampen the immune response and to reduce inflammation in the heart. Find out more 👉 https://shorturl.at/e78Tr #HumanitasResearch #Cardiology #HeartFailure #Cardioimmunology

Yesterday, we had the pleasure of hosting a joint seminar featuring two esteemed researchers and genomics experts from Human Technopole and Karolinska Institutet: 🗣️ Nicola Crosetto shared fascinating insights into single-cell genomics approaches to dissect intratumor genetic heterogeneity. 🗣️ Magda Bienko delivered an inspiring talk on the role of intronic RNAs in shaping genome architecture of neurons. The sessions, introduced by Enrico Lugli, offered a fantastic platform for our researchers and PhD students to exchange ideas and explore cutting-edge methodologies in the genomics field. Collaborative events like this underscore the importance of cross-institutional partnerships in advancing science and inspiring the next generation of researchers. A heartfelt thank you to everyone involved for making this seminar such a success! #HumanitasResearch #Hunimed #PhDstudents #Genomics #ResearchInnovation

🔬 A recent study published in Cell Host & Microbe, found that #antibiotic treatment during gestation could contribute, via breast milk, to a higher risk of intestinal infections and bacterial translocation from the gut into the bloodstream in newborns, potentially leading to sepsis. The study was led by Prof. Maria Rescigno – Vice Rector for Research at Humanitas University and Deputy Scientific Director for Basic Research at Humanitas Research Hospital, in collaboration with Dr. Carlo Pietrasanta – researcher at Università degli Studi di Milano and physician in Neonatology and Neonatal Intensive Care at Ospedale Policlinico di Milano.   Although restricted to preclinical models, the study results could suggest new strategies to monitor and protect newborns, especially preemies, from the unwanted effects of antibiotics.   Find out more 👉 https://shorturl.at/jluNJ   #HumanitasResearch #Hunimed #Immunology #NeonatalHealth #Antibiotics

🌟 We are thrilled to unveil the new #3DInnovationLab: located in the state-of-the-art Roberto Rocca #InnovationBuilding, this cutting-edge facility is set to revolutionise healthcare and life sciences by harnessing the transformative power of 3D printing technologies. Led by Eng. Paolo Oliva – Head of Research Technology at Humanitas, the lab brings together a #multidisciplinary team of biomedical researchers, bioengineers, and scientists to drive innovation through collaboration across clinical practice, scientific research, and university education. The lab features an impressive array of advanced tools: 🔹 High-definition 3D #scanners for capturing detailed images of anatomical structures. 🔹 3D #printers capable of creating life-like organ models, essential for medical training and testing. 🔹 The #Electrospider 3D bioprinter, developed with Bio3DModel and Università di Pisa, for replicating human tissue, including tumors, at both macroscopic and microscopic scales. 🔹 A #bioindenter for replicating the biomechanical properties of tissues, essential for challenging surgical applications. From creating realistic tissue models for training healthcare professionals, to creating patient-specific phantom organs for surgical planning, the Lab is unlocking new possibilities for precision medicine and personalised care. Discover more 👉 https://shorturl.at/CGJW3 #HumanitasResearch #Hunimed #3DPrinting #Innovation #Healthcare

🔬🧑🔬 On Tuesday 19th November, the MEDTEC School brought together over 50 students from different years of study to celebrate the second annual #MEDTECResearchDay! The day kicked off with inspiring welcome greetings from Prof. Luigi Maria Terracciano – Rector of Humanitas University, and Prof. Isabella Nova – Executive Vice Rector of Politecnico di Milano, who underlined the research synergies and collaborations between the two Universities. Throughout the event, students showcased a diverse range of impressive research projects. After months of hard work and dedication, three outstanding projects were recognised by the Faculty for their innovation and impact. The winners are: 🏆 Giulia Grion and Kirollos Roufail – 5th-year students 🏆 Luca Maria Menga and Lorenzo Profeta – 6th-year students 🏆 Andrea Brunati – 6th-year student A huge shout-out to these incredible students for their dedication, passion, and creativity in advancing research that truly makes a difference. Congrats 👏💚👏 Events like this highlight the vibrant Hunimed’s academic community, where collaboration and discovery thrive. Here’s to many more milestones on the journey of innovation! #humanitasuniversity #hunimed #medicine #medtec #medschool #hunimedlife #studentlife #healthcare

We were glad to host the #GRADE Workshop for Planetary Health at Humanitas University last week. Experts from renowned institutions around the globe met at our campus to discuss the critical intersection of human health, healthcare practices and the health of our planet. The workshop, led by Prof. Thomas Piggott from McMaster University, in collaboration with the Clinical Epidemiology and Research Center directed by Prof. Holger Schünemann, highlighted the role of health technology and guideline assessments in supporting human health while acknowledging the environmental impacts of healthcare. Sustainable practices in health are more important than ever, since we know that human health, animal health, and the planet’s health are inextricably linked. Topics covered included the use of single-use plastics, carbon emissions from transport and ways to promote environmentally conscious healthcare interventions 💡🌿 Thank you to everyone who joined us, asked thought-provoking questions, and contributed to this important conversation. Together, we're working toward a healthier planet 🌎 #HumanitasResearch #PlanetaryHealth #SustainableHealthcare #GRADE #PublicHealth

🧬🔬 Exciting breakthrough in #GeneticResearch: a new study highlights how anomalies in DNA sequences can have different effects depending on their positioning with respect to chromatine folding. Published in Genome Medicine and led by Dr. Giampaolo Trivellin – Neuroendocrinology Research Coordinator at the Translational Endocrinology Laboratory and Assistant Professor at Humanitas University, the research focuses on the GPR101 gene, which is linked to a rare form of pituitary gigantism, revealing that not all duplications lead to the same outcomes. Done in collaboration with researchers Martin Franke from the Andalusian Center for Developmental Biology (CABD) CSIC-UPO-JA in Seville, and Adrian Daly from the University Hospital Center in Liège (Endo-ERN - European Reference Network), and thanks to the support of Fondazione Telethon, this study sheds new light on the role of DNA's three-dimensional structure in disease expression. It opens new doors for more accurate diagnosis and personalised treatments for those affected by rare genetic conditions. Read more 👉 https://shorturl.at/wbM53   #HumanitasResearch #Hunimed #RareDiseases #ScientificInnovation

Yesterday, our PhD students had the opportunity to meet and discuss with Giannicola Genovese from The University of Texas MD Anderson Cancer Center during our weekly journal club. Introduced by Sara Lovisa, Genovese also delivered an insightful seminar on the role of cell plasticity and clonal heterogeneity as drivers of cancer progression, metastatic dissemination, and resistance to therapy, a field where he is giving seminal contributions. Great to have you here! #HumanitasResearch #Hunimed #PhDstudents #CancerResearch