M20 Genomics

🔬 Efficient #FFPE Sample Preparation & Processing for the VITA Single-Cell #Transcriptome Platform 🔬 Since its launch in 2023, the VITA single-cell transcriptome solution has transformed the application of the single-cell transcriptome technology in formalin-fixed paraffin-embedded (FFPE) samples, a task that was once very challenging. Researchers can now leverage archived #clinical FFPE samples for in-depth studies of diseases, expanding the scope and convenience of research. In our latest article, we share essential #tips to streamline FFPE sample preparation and processing on the VITA platform, based on feedback from users. Discover practical insights on tissue thickness, sample handling, and optimizing reagent interaction for smoother workflows and high-quality single-cell data. 🔗 https://lnkd.in/dhgHUidr Stay tuned for more tips on maximizing the potential of your samples in VITA single-cell transcriptome experiments! #FFPESamplePrep #SingleCellSequencing #VITATips #TranscriptomeAnalysis #RNASequencing #M20Genomics #BiomedicalResearch #SingleCellRNASeq

🎉 Publication Alert! 🎉 Singapore, December 2024 - We're excited to share the latest publication titled “High-Throughput Single-Nucleus RNA Profiling of Minimal #Puncture FFPE Samples Reveals Spatiotemporal #Heterogeneity of Cancer" in Advanced Science! 🔍 Key Highlights: 🔬Researchers optimized the snRandom-seq by implementing a pre-indexing procedure, enabling robust analysis of small #FFPE puncture biopsy samples. 🧬The optimized method achieved impressive results, detecting ~17,000 genes and 12,000 long non-coding RNAs (#lncRNAs) across 20 solid tumor samples. 💊The study uncovered dynamic spatiotemporal heterogeneity in liver metastases from colorectal cancer patients undergoing immunotherapy, providing insights into pseudo progression. ✨The VITA platform played a pivotal role in enabling precise single-cell and non-coding RNA detection and analysis for minimal FFPE samples. Its high sensitivity and advanced workflows helped unlock deeper insights into tumor heterogeneity and immune responses. This breakthrough demonstrates the power of the cutting-edge technology, VITA Single-Cell Transcriptome Platform, in advancing cancer research and enabling transformative discoveries. 📖 Read the full article here: https://lnkd.in/dPm5yYpj #SingleCellSequencing #FFPESamples #CancerResearch #Immunotherapy #VITAPlatform #M20Genomics #Biopsy

🦠#Bacterial infections rely on intricate interactions among different species. Understanding these dynamics within mixed populations is crucial for developing effective prevention and treatment strategies. Our #randomprimer-based #VITA MscRNA-seq facilitates #scRNAseq in mixed bacterial cultures. It effectively characterized a culture of Klebsiella pneumoniae and Escherichia coli, precisely dissecting both species, identifying intra-species subpopulations, and enabling the analysis of differential gene expression at the single-cell level.  Such insights into the heterogeneity of bacterial populations empower you to decode mechanisms behind pathogenicity or antibiotic resistance, driving breakthroughs in new prevention and treatment strategies for infections.  Learn how VITA MscRNA-seq helps you to explore the microbial universe and join us in shaping the future of microbiology: https://lnkd.in/dpHaSNmD #micorbiology #mixedpopulations #bacteria #scRNAseq #M20

Empowering AMR Research with VITA High-Throughput Single-Cell Transcriptome Technology 🔬 The World #AMR Awareness Week (WAAW) is celebrated from 18-24 November every year (https://lnkd.in/ebwEkFxe). Antimicrobial resistance (AMR) is one of the most pressing threats in modern medicine, and understanding the molecular mechanisms driving resistance is crucial to tackling it effectively.  At M20 Genomics, we’re empowering AMR researchers with our high-throughput single-bacterium transcriptome technology. This cutting-edge approach provides unprecedented insights into the gene expression profiles of individual bacteria, revealing the heterogeneity within microbial populations that fuels resistance evolution. Whether your work focuses on: ✅ The emergence of resistance under antibiotic pressure – uncovering how selective pressures drive resistance evolution, ✅ Interactions within the microbiome and between microbiome and host – shedding light on how microbial communities and host environments influence resistance dynamics, or ✅ Mechanisms driving persistence and tolerance – exploring how bacteria evade eradication even under treatment, Our cutting-edge platform offers the precision and scalability to deliver actionable insights into these critical areas. Let’s work together to advance AMR research and safeguard the effectiveness of antibiotics for future generations.  📩 Reach out info@m20genomics.com to learn how M20 Genomics can support your research goals! #AMRResearch #SingleCell #MicrobiologyInnovation #WHO #AntimicrobialResistance #M20Genomics

🚀 New Product Release: The VITA Fixed RNA Reagent for Flexible Single-Cell Research! 🔬 Singapore, November 2024 - M20 Genomics is thrilled to announce the launch of the VITA Fixed RNA reagent—a groundbreaking advancement that expands the possibilities of single-cell research across diverse experimental settings. 💡 The VITA Single-Cell Transcriptome Platform has been a trusted tool for high-throughput, full-length transcriptome sequencing, compatible with fresh, frozen, and FFPE tissues. However, we've taken it a step further! The VITA Fixed RNA reagent addresses challenges like field sample collections, where immediate processing or freezing isn't feasible. With this new reagent, you can directly fix tissue samples, allowing for broader handling options, greater flexibility, and confidence in your single-cell sequencing workflow—no matter the environment or circumstance. Key Highlights: ·       Immediate stabilization of tissue samples upon collection ·       Proven reliable performance in diverse tissue preservation conditions ·       Compatible with our VITA single-cell experimental workflows 🔬 VITA Fixed RNA reagent unlocks new opportunities for researchers, enabling deeper insights into cellular function and disease mechanisms, while ensuring high-quality data across different tissue preservation conditions. 📧 Ready to explore the future of single-cell research? Read more on our website (https://lnkd.in/d4K68bxq) or contact us at info@m20genomics.com to learn how VITA Fixed RNA can elevate your research.

Every year, cardiovascular diseases (#CVDs) claim millions of lives. Recent research has unveiled the significant role of the #gutmicrobiome as a crucial player in cardiovascular health. The composition of species, metabolic pathways, and microbial products tightly correlate with various CVDs. However, conventional bulk methods struggle to capture the heterogeneity within complex microbial communities and to elucidate the individual roles of microbes.  #VITA GutMicrobiome, the cutting-edge solution for #scRNAseq directly from #gutmicrobiota samples, delivers groundbreaking insights into the gut microbiota and their influence on host cardiovascular health. This advanced technology significantly enhances precision in quantifying relative bacterial abundance, identifying rare populations, and profiling microbial metabolic activities through comprehensive transcriptome profiles of individual microbes. Explore the microbial universe and discover how VITA GutMicrobiome unveils new insights into the connection between the gut microbiota and cardiovascular health here:https://lnkd.in/dCKRHRRe #Singlecell #Biotech #Microbiome #Transcriptome #Cardiovascular

🚀 M20 Spatial Technology: Pioneering Insights into Breast Cancer Heterogeneity 🚀 Singapore, October 2024 - We’re thrilled to share the latest data from the enhanced M20 Spatial, the world’s first random-priming-based comprehensive spatial transcriptome technology—now with greater sensitivity for #FFPE samples! 🔹 Enhanced Detection Capabilities Breast Cancer Tissue: 37,862 genes detected across 2,682 spots, yielding a median UMI count of 28,852 and a median gene count of 5,421 per spot. Peritumoral Tissue: 38,434 genes detected across 1,307 spots, with a median UMI count of 30,065 and median gene count of 5,839 per spot. 🔹 Full-Length Transcriptome Coverage Achieves unbiased, full-length gene body coverage, revealing spatial heterogeneity from 5' to 3' ends without third-generation sequencing requirements. 🔹 Non-Coding RNA Detection Captures diverse RNA molecules, including ~1,000 miRNAs—a timely addition given the recent Nobel Prize awarded to miRNA discovery! 🔹 In-Depth Tumor Profiling Notable upregulation of ERBB2 (HER2) and downregulation of ESR1/PGR in breast cancer tissues, highlighting potential HER2-positive subtypes. 🔹 Cell-Type Spatial Heterogeneity Integration with VITA single-cell transcriptome data precisely delineates the spatial heterogeneity of cell type distribution within the tissue microenvironment. The new data positions M20 Spatial as a key asset in cancer research, with potential for transformative insights into disease mechanisms and therapeutic targets. Learn more about our latest upgrade and its clinical implications at https://lnkd.in/dXb_38ba #biotechnology #spatialtranscriptomics #cancerresearch #breastcancer #RNA #biomarkers #M20Genomics #NoncodingRNA

🚨 Last Chance to Join the #Klebsiella Action Project (KAP)! 🚨 M20 Genomics invites researchers worldwide to join the Klebsiella Action Project (KAP), dedicated to advancing research against the hypervirulent Klebsiella pneumoniae ST23 (hvKp ST23). 🔬 The KAP project aims to empower the researchers worldwide in their pursuit of understanding and combating this deadly pathogen by leveraging the cutting-edge VITA single-cell transcriptome products. Each project may receive up to $60,000 in support, tailored to specific research needs. For more details, please click https://lnkd.in/dVfZPDKq 🗓️ The deadline is approaching! Submit your research proposal by October 31, 2024 to academic@M20genomics.com. Let’s work together to deepen our understanding and develop solutions against hvKp ST23. Join KAP today to make an impact on global health! #Research #Microbiology #Klebsiella #PublicHealth #SingleCellSequencing #KlebsiellaActionProject #Innovation #M20Genomics

🚀 Exciting Update from M20 Genomics! 🚀 Singapore, October 2024 - We’re thrilled to unveil the latest M20 Spatial technology upgrade, pushing the boundaries of spatial transcriptomics. This upgrade brings groundbreaking advancements in gene detection sensitivity, spatial resolution, and single-cell profiling integration. Here’s a glimpse of what’s new: 🔬 Enhanced Sensitivity – M20 Spatial now delivers unmatched precision, capturing richer datasets for spatial cellular relationships, even from challenging FFPE samples. 📏 Unparalleled Resolution – With the introduction of our in-house developed chip, M20 Spatial enables deeper insights into tissue microenvironments with superior spatial accuracy at 15µm resolution. 🧬 Integrated Single-Cell Profiling – Seamlessly combine M20 Spatial data with single-cell transcriptome for even more accurate cellular heterogeneity mapping and a clearer view of spatial molecular mechanisms. 🌟 Highlight: Recent data from mouse embryo and olfactory bulb samples demonstrate over 5000 genes detected at 50 µm resolution— a massive leap for spatial transcriptomics! M20 Spatial is revolutionizing how we understand spatial biology, offering researchers a versatile tool for cutting-edge discoveries in life sciences and biomedical research. 🌱 🔗 Curious to learn more? Please click https://lnkd.in/eTQsAT5s ✉️Reach out to us at info@m20genomics.com and explore the future of spatial biology with M20 Spatial!  #SpatialBiology #Transcriptomics #Genomics #ResearchInnovation

🚀 Exciting Launch of KAP with the Support of VITA: A Collaborative Effort to Combat #Multidrug-Resistant and Hypervirulent #Klebsiella pneumoniae 🌍 Last week, we officially launched the KAP initiative, a dedicated to accelerating research on hypervirulent Klebsiella pneumoniae (#hvKp) ST23—a growing global health threat—by utilizing the VITA single-cell transcriptome platform. Traditional research methods often overlook critical aspects, such as the functional heterogeneity within bacterial populations. 🧬Single-cell RNA sequencing (#scRNA-seq) offers substantial advantages, enabling high-resolution gene expression analysis at the single-cell level. This innovative approach reveals the diversity within 🦠 #bacterial populationsand identifies phenomena like #heteroresistance. Furthermore, scRNA-seq facilitates real-time monitoring of cellular responses to environmental changes, providing invaluable insights into how bacteria like K. pneumoniae adapt under #antibiotic pressure🧫. The VITA platform is uniquely equipped to help researchers unravel the key molecular mechanisms of K. pneumoniae resistance and virulence. As we embark on this journey, we invite researchers worldwide to collaborate with us. Together, we can enhance our understanding of #hvKp ST23 and develop innovative strategies to protect public health💪. For more details, visit: https://lnkd.in/dVfZPDKq 🧐Interested in joining KAP?  Submit your project proposal to academic@m20genomics.com by October 31, 2024. Let's tackle this public health challenge together! 💡🔬 #M20genomics #singlecell #WHO