Combat Medical Ltd

Great news to see so many millions of people getting involved in spreading the important messages about bladder cancer. With our HIVEC-HEAT trial getting underway in 2025, we're also excited about making a big impact in 2025. #medicalinnovation #bladdercancer #HIVEC #HIVECHEAT #CombatMedical

Could simple drugs and food supplements inhibit bowel polyp growth and thereby lower the risk of bowel cancer? The cancer-inhibiting properties of purified resveratrol – the antioxidant compound famously found in red grape skins and red wine – are being investigated in the new phase 2/3 COLO-PREVENT trial. It's being led by the NIHR (National Institute for Health and Care Research) and the University of Leicester, where previous research by Professor Karen Brown has shown that purified resveratrol can survive the stomach to reach the bowel undamaged, where it can slow down tumour growth, even at low doses. The trial is recruiting 1300 people aged 50-73 who have already been diagnosed with bowel polyps through the NHS Bowel Screening Programme. Following polyp removal, participants will take aspirin or aspirin plus melatonin daily for three years in the main trial, or resveratrol or a placebo daily in a 12-month sub-study.   At the end of the intervention, participants will undergo colonoscopies to see if they have new polyps, and if so, to compare their size to those removed at the start of the trial. If the trial succeeds, it could pave the way for a simple, cost-effective way to reduce bowel cancer risk, using compounds that are safe, well-tolerated and already in widespread use. #medicalinnovation #Decembeard #bowelcancer #coloncancer #HIPEC #CombatMedical

Interested in finding out what innovators and leading clinicians in surgical oncology and oncology are up to? Our Medical Innovators’ interviews on our YouTube channel feature in-depth discussions on research and advances in colon cancer, ovarian cancer and bladder cancer – all areas where our Combat PRS+ HIPEC and Combat BRS HIVEC® treatments are making a difference.   The interviews are also available as blogs on our website – links in comments below ⤵   If you’d like to share your own experiences and insight, please get in touch with Guy Cooper    #medicalinnovation #Decembeard #bowelcancer #coloncancer #ovariancancer #HIPEC #bladdercancer #HIVEC #CombatMedical

A fascinating new study published this week in Gut* has found a strong correlation between the typical Western diet – high in ultra-processed foods (UPF) and inflammatory seed oils – and colorectal cancer risk. The research signposts a new, natural approach for treating colorectal cancer more effectively – resolution medicine, which focuses on restoring balance in the patient’s diet to treat colorectal cancer more effectively. Resolution medicine aims to reverse inflammation using healthy, unprocessed foods rich with omega-3 fatty acids and fish-oil derivatives called specialized pro-resolving mediators to restore the body’s healing mechanisms. Exercise and improved sleep quality would also play an important role. The researchers hail its potential to revolutionise cancer treatment by addressing chronic inflammation and preventing diseases before they start. *Soundararajan R et al. Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer. Gut Published Online First: 10 December 2024. doi: 10.1136/gutjnl-2024-332535 #medicalinnovation #Decembeard #bowelcancer #coloncancer #HIPEC #CombatMedical

Yesterday’s post about the new study published this week in Gut*, which has found a strong correlation between the typical Western diet – high in ultra-processed foods (UPF) and inflammatory seed oils – and colorectal cancer risk. “Our bodies are designed to actively resolve inflammation through bioactive lipid compounds derived from the healthy fats, like avocados, that we consume,” said Ganesh Halade, associate professor at the University of South Florida Heart Institute and a member of the Cancer Biology Program at Tampa General Hospital (TGH) Cancer Institute. “Bioactive lipids are very small molecules derived from the foods that we eat. If the molecules are coming from processed food products, they directly imbalance the immune system and drive chronic inflammation.” Halade’s team used a highly sensitive analytical technique to identify trace amounts of lipids in 162 tumour samples from patients at TGH. They discovered an excess number of molecules that promote inflammation and a shortage of those that help resolve it and promote healing. “The immune system can be extremely powerful and drastically impact the tumour microenvironment, which is great if harnessed correctly for health and wellness – but not if it’s suppressed by inflammatory lipids from processed foods,” said Dr Timothy Yeatman, professor of surgery in the USF Health Morsani College of Medicine and associate centre director for Translational Research and Innovation at the TGH Cancer Institute. *Soundararajan R et al. Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer. Gut Published Online First: 10 December 2024. doi: 10.1136/gutjnl-2024-332535 #medicalinnovation #Decembeard #bowelcancer #coloncancer #HIPEC #CombatMedical

Just as many of us start finalising our plans for the annual December festival of overeating and drinking – also known as Christmas – along comes a thought-provoking new study in Gut* that might make you want to swap the pigs in blankets for extra Brussels sprouts. It suggests that overconsumption of ultra-processed foods (UPF) and inflammatory seed oils (typifying the Western diet) may be fuelling the chronic inflammation that drives the growth and progression of colorectal cancer. Researchers at the University of South Florida (USF) and Tampa General Hospital (TGH) Cancer Institute have shown that the increased level of inflammation seen in the bodies of people with unhealthy diets is also present in the colon tumours themselves. Dr Timothy Yeatman, professor of surgery in the USF Health Morsani College of Medicine and associate centre director for Translational Research and Innovation at the TGH Cancer Institute, explained: “Cancer is like a chronic wound that won't heal. "If your body is living off daily ultra-processed foods, its ability to heal that wound decreases due to the inflammation and suppression of the immune system that ultimately allows the cancer to grow." The findings signal the urgent need to reevaluate the Western diet. Previous research conducted by the USF Health Heart Institute showed that an imbalanced diet not only influences colorectal cancer but also plays a role in other diseases, including diabetes, cardiovascular conditions and Alzheimer’s. More food for thought tomorrow! *Soundararajan R et al. Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer. Gut Published Online First: 10 December 2024. doi: 10.1136/gutjnl-2024-332535 #medicalinnovation #Decembeard #bowelcancer #coloncancer #HIPEC #CombatMedical

Bowel (colorectal cancer) is the fourth most common cancer in the UK, with 1 in 15 men and 1 in 18 women being diagnosed every year.   Risk factors include 👉 Being over 50 years of age 👉 Strong family history of the disease (with ≥3 close relatives who have had bowel cancer) 👉 Personal history of bowel polyps 👉 Chronic inflammatory bowel disease, such as ulcerative colitis or Crohn’s 👉 Type 2 diabetes 👉 Unhealthy lifestyle   This Decembeard, men are coaxing their beards to grow (some more successfully than others) to trigger conversations (or laughter) that raise awareness of this disease. This is key, because 90% of patients diagnosed in stage 1 will survive for at least 5 years with timely treatment. Our Combat PRS+ Agitation technology is being used to deliver hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of bowel cancer. Look out for more posts this month!   #medicalinnovation #Decembeard #bowelcancer #coloncancer #HIPEC #CombatMedical

Our Medical Innovators’ interviews on our YouTube channel feature leading clinicians in surgical oncology and urology discussing colon cancer, ovarian cancer and bladder cancer – all areas where our Combat PRS+ HIPEC and Combat BRS HIVEC® treatments are making a difference.   The interviews are also available as blogs on our website – links in comments below ⤵   If you’d like to share your own experiences and insight, please get in touch with Guy Cooper   #medicalinnovation #bowelcancer #coloncancer #ovariancancer #HIPEC #bladdercancer #HIVEC #CombatMedical

Following on from the last post – describing the first experience of the Combat PRS+ recirculation system with CO2 agitation in Latin America as presented at the 4th Latin American Congress on Peritoneal Neoplasms in Frutillar, Chile last week…   RESULTS   ▶️ CRS included modified radical hysterectomy, bilateral salpingo-oophorectomy, appendectomy, cholecystectomy, splenectomy, major and minor omentectomy, pelvic peritonectomy, bilateral diaphragmatic stripping, and resection of implants on mesenteric and intestinal surfaces. PCI: 20/39; CCS: 0   ▶️ After CRS, four multiperforated catheters were placed: 2 in the upper abdomen (infusion for chemotherapy) and 2 in the lower abdomen (aspiration of CO2 infusion), connected to the CO2 Recirculation System (Combat PRS+A®) with a cavity temperature probe   ▶️ Closed HIPEC performed with OVHIPEC-1 protocol using cisplatin (100 mg/m2) over 90 minutes at 43°C, without complications or alerts. Intervention included cavity fluid washing and closure with intra-abdominal drains   ▶️ The patient stayed in the ICU for 48 hours and was discharged on day 10   ▶️ Postoperative course showed no haematological, renal, or gastrointestinal complications. Histopathology confirmed high-grade serous carcinoma with positive markers (CK7, WT1, PAX8) and HRD positive (BRCA 1/2 not mutated). Treated with Niraparib as maintenance therapy   ▶️ Follow-up at 3 months: excellent response without recurrence   CONCLUSIONS   “The HIPEC technique with CO2 recirculation is safe and reproducible, representing the first experience in Latin America with favorable results. Its application may improve outcomes in patients with peritoneal carcinomatosis and offers an alternative for treatment in advanced peritoneal tumors.”   #medicalinnovation #peritonealcancer #HIPEC #CombatPRS #CombatMedical