NeuroAge Therapeutics

NeuroAge is not currently hiring. If you receive a message offering you a job from someone supposedly at NeuroAge, that's not us, it's a scam. Please don't interact with them or give them any sensitive information.

Honored to be amongst Lifespan.io Longevity News's best talks of the Longevity Global Summit. "The debate around amyloid’s role in Alzheimer’s disease has dominated the field for decades. However, according to Dr. Christin Glorioso, who, this time, was wearing her NeuroAge Therapeutics founder hat, we might need to think about it differently. “Amyloid is a risk factor, like cholesterol,” she said. “We should think about it not as the single cause of Alzheimer’s disease, but one cause among many.” Alzheimer’s is multifactorial and doesn’t look the same in all people, Glorioso noted. This means that we need better biomarkers and segmentation to predict who anti-Alzheimer’s drugs will work for. It is also important to diagnose the disease and identify responders and non-responders earlier, since current drugs have been shown to work better at an early stage. Glorioso’s company is focusing on aging itself as a key risk factor. Her research shows that pathological processes in brain cells start surprisingly early. “Even in your 20s,” she explained, “you have calcium dysregulation, mitochondrial dysfunction, DNA damage, changes in neurotransmitters, and brain-specific hallmarks like loss of synapses between neurons and inflammatory processes in glia.” By studying donated brain tissue, Glorioso’s team discovered many genes that show pro-Alzheimer’s age-related changes, such as calbindin and GFAP. This allowed the researchers to create an algorithm that predicts brain age from 52 blood RNA transcripts. “This is an organ-specific aging clock, similar to Tony Wyss-Corey’s work with proteomics, but using RNA-seq as a more accessible approach,” Glorioso said. “You go to your doctor yearly to check cholesterol for heart disease risk and glucose for diabetes risk, but no one checks brain aging – we didn’t have a way to assess neurodegeneration risk.” The final product is an “AI-based super predictor” that combines blood biomarkers, genetics, brain MRI, and cognitive testing to predict brain age. This information is actionable, Glorioso said, “because about 40% of your brain aging rate is due to lifestyle, with 60% genetic. There’s this huge modifiable component you can work on right now to reduce your brain aging.” Glorioso cited recent research that supports this approach. A new study showed that just 25 extra minutes of exercise per week increased brain volume on MRI – “literally growing their brains back,” as Glorioso put it. In another case, an entrepreneur with high genetic risk for Alzheimer’s managed to reverse his amyloid accumulation through intensive lifestyle changes. Glorioso’s company provides its clients with a comprehensive dashboard that includes measurements of their brain age and lifestyle recommendations..." https://lnkd.in/gfEmgUMW

The Best Talks From Longevity Summit 2024 Biomarkers, clocks, splicing, and brain aging were all featured. Thanks for writing up the Longevity Global Summit Lifespan.io Longevity News! Nice summaries of work by Madeleine Cule (Calico Life Sciences), David Furman (Buck Institute for Research on Aging), Ashley Webb (Buck Institute), Vittorio Sebastiano (Stanford University, Turn Biotechnologies), Mike (Przemyslaw) Sapieha (UNITY Biotechnology), myself (NeuroAge Therapeutics), Lorna Harries (SENISCA). "Earlier this month, for the third year in a row, the famed Buck Institute for Research on Aging hosted the Longevity Summit. This two-day event was organized by Longevity Global, a community of longevity researchers, investors, and enthusiasts, and its founder Dr. Christin Glorioso. While not the biggest or the longest conference in the field, Longevity Summit has consistently attracted top-tier speakers and audience members. We are happy to bring you a selection of talks from the event. As is our custom, we apologize to the equally worthy speakers whose talks we were unable to include." Read more: https://lnkd.in/gfEmgUMW

FDA has redefined what foods have the "healthy" label from the 1994 guidelines, which included white bread and sugary juice boxes and didn't include foods high in good fats, like olive oil and salmon, or with higher cholesterol levels, like eggs. This guidance is reflective of what we know now- foods high in cholesterol do not actually raise your cholesterol levels, highly processed foods and those high in added sugar are bad for your health, and whole grains, fruits, and vegetables are part of a healthy diet. I'm glad that we are not in the 1990s anymore- low fat, high sugar, processed junk food was the norm and it was bad for us and also did not taste good. Read more about the healthy label: https://lnkd.in/ghyzmCQf

Ozempic for Alzheimer's? Two large studies come out in 2025 that should shed more light on this. I would put money on GLP1s becoming a mainstay recommendation for Alzheimer's prevention and treatment in pre/diabetics/overweight. https://lnkd.in/gaXZq4A6

New publication links lifestyle to brain aging. No surprise that exercise is king for having a biologically younger brain. Biological brain age and resilience in cognitively unimpaired 70-year-old individuals "We derived BAG by subtracting predicted brain age from chronological age in 739 septuagenarians without dementia or neurological disorders. Robust linear regression models assessed BAG associations with life exposures, plasma inflammatory and metabolic biomarkers, magnetic resonance imaging, and cerebrospinal fluid biomarkers of neurodegeneration and vascular brain injury, and cognitive performance... Greater BAG (older-looking brains) was associated with physical inactivity, diabetes, and stroke, while prediabetes was related to lower BAG, that is, younger-looking brains. Physical activity mitigated the link between obesity and BAG. Greater BAG was associated with greater small vessel disease burden, white-matter alterations, inflammation, high glucose, poorer vascular-related cognitive domains. " Read the science: https://lnkd.in/gJB9YH3e

How old is your brain biologically? For a limited time only, you can find out by playing NeuroGames online for free at : https://lnkd.in/gSF8_M56.

We are thrilled to be partnered with some of the best longevity and concierge physicians practicing, including Dr. Joseph Raffaele, MD. Thanks so much for writing about brain aging and the NeuroAge Test (https://lnkd.in/g9tnKMDN).

I had a great time speaking at the Biomarkers of Aging Consortium Symposium at Harvard Medical School this past November. Thanks so much to the organizers for the invitation. You can now watch my talk on their YouTube channel: https://lnkd.in/dUjearmQ

Thrilled to share some highlights from the NeuroAge Test Launch Party on Dec 5th at MBC BioLabs in San Francisco! After two decades of research, the NeuroAge Test is finally available for purchase—offering insights into brain aging and dementia risk up to 30 years in advance using MRI, NeuroGames, RNA biomarkers, and genetic profiling. Huge thanks to our guests, investors, panelists and the incredible team- Francesco Neri, Persiana Cota, MA, NBC-HWC, Sam Lee, Emani H., Lionel Church, Yuriy Golikov, Maksym Shevchenko, Krishna B., Justin Taylor, Christina Peterson, LICSW, Ronjon Nag, Joseph Raffaele, MD, Patrick Sanger, MD, PhD- for making it an unforgettable celebration. Learn more and explore the NeuroAge Test at neuroagetx.com. You can take 20% off all of our offerings with code "Launch20". Was so great to have some good friends there Antoine Emile Roux, Sergiy Libert, Mark Doyal, Stephen Hubbard. #NeuroAgeTest #BrainHealth #Longevity