Abhilash Banerjee’s Post

Johnson & Johnson's seltorexant significantly improved depression and insomnia in a phase 3 trial. This breakthrough drug, used with existing antidepressants, met all primary and secondary endpoints in a study of 588 patients. Impact - Potentially a game-changer for treating depression with insomnia, addressing a major unmet need. Insights - ▪️ Highlights the crucial link between depression and sleep. ▪️ Demonstrates strong efficacy and safety. Questions - ▪️ How will seltorexant reshape MDD treatment? ▪️ What further research is needed? #MentalHealth #Depression #Insomnia #ClinicalTrials

337 million prescriptions for antidepressants were written in 2021. However, they aren't effective for everyone and some may even get worse. Why? Brain types differ in depression, based on several factors. The Amen clinic classifies 7 types of depression based on brain function. In those with issues in the prefrontal cortex, antidepressants may worse. For some, overactivating this region can make mood worse. Furthermore, many have side effects, some severe, including risk of suicide and harm. Addressing the foundational brain health factors first is paramount for brain health and modulating mood. These include genetics, lifestyle, inflammation, hormones, infections, nourishment, oxidative stress, and more. In my post, I review why serotonin modulation with drugs may be beneficial for some, when we consider inflammation, brain type, and methylation. I discuss Dr. Amen's methods in one of these categories. I also wrote a post on how essential oils support many aspects of brain health and can be an ally in any form of mental health treatment. Links: https://buff.ly/3YPmepO My post on the links to serotonin and depression https://buff.ly/3lakE3Z Essential Oils: https://buff.ly/3ySXw0M #depression #antidepressants #mindbody #dopamine #inflammation #inflammedbrain #serotonin #serotoninanddepression #brainhealth #mentalhealth #mood #ssris #antidepressant #essentialoils

How much alcohol is safe? A patient asked me one day. My answer can make you angry. Because there is no safe level of alcohol a day. Whatever the numbers, alcohol is a risky slope. You might slip down and the consequences can be fatal. Here are a few myths related to alcohol that are a big no-no! ❌ Myth #1: I can handle my liquor, so I'm not at risk. Fact : Alcohol consumption can lead to liver disease, cardiovascular problems, neurological damage, and an increased risk of accidents and injuries. ❌Myth #2 : Drinking in moderation means I'm not at risk. Fact : You will never know when you end up being addicted and a burden on your liver. ❌Myth #3: Alcohol doesn’t affect you much if you mix it with non-alcohol drinks. Fact : consuming a mixture of beverages can lead to unpredictable effects on the body. Low risk doesn't mean no risk. As a neurologist, I’ve seen so many young people losing their lives leaving behind a family, or being a financial burden and compromised life because of drinking habits. So, don't feed yourself with excuses to gulp a drink or two. You can have fun in life without alcohol. But if you need alcohol to have fun, you need to improve your life. What do you think about alcohol consumption? #neurology #alcoholaddiction #alcoholawareness

Dive into the fascinating world of neurotensin, a powerhouse neuropeptide with superhero-like roles in both the brain and digestive system! 🌟 In this video, we explore neurotensin's interactions with dopamine, its natural painkilling abilities, and its crucial role in regulating stress response and body temperature. Discover how neurotensin influences feeding behavior, sleep cycles, and even offers neuroprotective qualities against aging and neurodegenerative diseases. Join us as Dr. Lado shares his personal connection to schizophrenia and advocates for further research on neurotensin's therapeutic potential. Let's unlock the mysteries of neurotensin together! 🧠🌿 #Neurotensin #Neuropeptide #Dopamine #Schizophrenia #PainManagement #StressRelief #Neuroprotection #MentalHealth #ScientificResearch#ladohealinginstitute Remember to like and share this video with those who might find it enlightening!

Anxiety Won't Disappear? Check for Underlying Liver Dysfunction! Did you know Anxiety may signal liver dysfunction? Chronic liver issues can lead to elevated cortisol levels, which are closely linked to increased anxiety. Additionally, the liver plays a key role in regulating mood; dysfunction can disrupt the metabolism of neurotransmitters like serotonin, potentially leading to anxiety disorders. Read full article at https://lnkd.in/gukB-vtA

Did you know that depression affects 17 million adults in the US and can be difficult to treat? Researchers have been exploring the role of neurotransmitters like serotonin and norepinephrine in depression, but recent studies have led them to focus on glutamate and GABA, which are crucial for neuroplasticity 🧠. Ketamine, an anesthetic, has shown rapid antidepressant effects by helping the brain regrow synaptic connections between nerve cells. FDA-approved last year, ketamine is a promising treatment for patients who haven't responded to other antidepressants. Combining ketamine with therapy can help prevent relapse and develop new coping strategies. Watch this videa as Yale explains how Ketamine works for depression! https://lnkd.in/gdqyg7Y5 #KetamineForDepression #MentalHealthAwareness #BreakTheStigma 🌟

Want a stronger immune system, improved mood, digestion and HRV? Try singing in the car or shower. 🎤 Since becoming a mom I love nerding out and reading scientific journals, especially on anything having to do with regulating the nervous system 😅. Turns out stimulating your vagus nerve, which represents the main component of your parasympathetic nervous system, can have many positive benefits to your overall health. Singing, gargling, humming and chanting are all easy, free ways to stimulate your vagus nerve. Bonus points if you sing a song (belt it out) that has you on the verge of tears. There is something about the increased throat constriction while singing that really ratchets up the stimulation of the vagus nerve (it’s science). My favorite song to sing when nobody is listening? Zombie - The Cranberries (2nd place You Oughta Know - Alanis Morissette) What are you singing when nobody can hear? Share with me (and your entire professional network) in the comments!

Anxiety Won't Disappear? Check for Underlying Liver Dysfunction! Did you know Anxiety may signal liver dysfunction? Chronic liver issues can lead to elevated cortisol levels, which are closely linked to increased anxiety. Additionally, the liver plays a key role in regulating mood; dysfunction can disrupt the metabolism of neurotransmitters like serotonin, potentially leading to anxiety disorders. Read full article at https://lnkd.in/gMg8h6xs

Depression is associated with disruptions to several closely related neural and cognitive processes, including dopamine transmission, fronto-striatal brain activity and connectivity, reward processing and motivation. Physical activity, especially aerobic exercise, reduces depressive symptoms, but the mechanisms driving its antidepressant effects are poorly understood! There is robust evidence that aerobic exercise decreases systemic inflammation. Inflammation is known to reduce dopamine transmission, which in turn is strongly implicated in effort-based decision making for reward; however, aerobic exercise is known to decrease this systemic inflammation. By reducing inflammation and boosting dopamine transmission, exercise improves ‘interest-activity’ symptoms of depression—namely anhedonia, fatigue and subjective cognitive impairment - by increasing propensity to exert effort. From this, cognitive impairment in depression may also be conceptualised through an effort-based decision-making framework, which may help to explain the impact of exercise on cognitive impairment. Overall, understanding the mechanisms underlying the antidepressant effects of exercise could inform the development of novel intervention strategies, in particular personalised interventions and boost social prescribing. Learn more: https://lnkd.in/gBT_KcFf One love #brain #exercise #antidepressant

𝐒𝐦𝐚𝐫𝐭 𝐃𝐫𝐮𝐠/𝐒𝐭𝐮𝐩𝐢𝐝 𝐃𝐫𝐮𝐠 - 𝐀𝐥𝐜𝐨𝐡𝐨𝐥 About 88,000 people die each year in the United States due to alcohol use, according to the Centers for Disease Control and Prevention. Internationally, the burden is 3.3 million per year, accounting for nearly 6 percent of all global deaths. Even without the deaths, 15 million U.S. adults and another 623,000 adolescents have what doctors now call alcohol use disorder: a chronic, relapsing brain disease characterized by an inability to stop or control alcohol use despite adverse social, occupational, or health consequences. But here’s the thing about alcohol: in moderation — no more than two drinks per day for men or one per day for women — it appears to modestly reduce the risk of heart disease, stroke, diabetes, and death according to the Harvard School of Public Health. Psychologist Jennifer Wiley of the University of Illinois even published a study in 2012 showing that a few drinks can actually improve people’s ability to find creative solutions to puzzles, especially increasing the chances that a person will have novel insight. All in all, we are left with evidence that is modest, at best, to justify the use of moderate alcohol. What’s beyond doubt, on the other hand, is that more brains and lives are ruined by overuse of alcohol than by any other substance. For this reason, I wouldn’t call it a smart drug. #alcohol #alcoholaddiction #neuroscience #brain #brainhealth