Advances in Clinical and Experimental Medicine ’s Post

📰 We are thrilled to share our latest publication: "New insights in immunomodulation for intestinal transplantation."   📌 Achieving tolerance in solid organ transplantation remains a significant challenge. This is especially true for intestinal grafts due to the small bowel's high immunogenicity. This review highlights the foundational chimerism theory introduced by Thomas Starzl, provides an overview of our current understanding of tolerance in intestinal transplantation, and outlines recent advances in the field. To illustrate, we also focus on the Leuven immunomodulatory protocol, a pro-tolerogenic approach initiated in 2000 which includes several interventions designed to enhance graft acceptance.   👊 Special thanks to Professor Laurens Ceulemans for his tremendous mentorship and unwavering support, and to Professor Jacques Pirenne for his crucial guidance. Gratitude also to all the co-authors for their significant assistance. Emilio Canovai Xin Jin Charlotte Hooft bart vanaudenaerde Caroline Boelhouwer Tim Vanuytsel   🔍 https://lnkd.in/en2CqUwF   #Transplantation #Immunology #IntestinalTransplantation #Immunomodulation #Chimerism #LeuvenProtocol #OrganTransplantation #MedicalResearch #ClinicalAdvances

New therapy proven effective against rejection in kidney transplantation - Medical Xpress New therapy proven effective against rejection in kidney transplantation  Medical Xpress Learn more https://lnkd.in/edCPyCyg

👏 To share with you a new algorithm to identify potential ACLF patients, hopefully to help more people. It was recently published in Prof. @Jean Francois D. Cadranel's special issue "Cirrhosis and Its Complications": Johnson A, Habib S. Liver transplantation consideration and evaluation: a life-saving treatment in acute-on-chronic liver failure. Explor Dig Dis. 2024;3:262–74.

Title: Continued hypothermic and normothermic machine perfusion without a perfusion solution switch   S.B. Bodewes   Summary Liver transplantation is the only treatment for end-stage liver disease, but donor shortages necessitate expanding donor criteria. Sequential hypothermic and normothermic machine perfusion make it possible to asses the viability of high-risk donor livers. However, this protocol suffers from additional cold ischemia time and complexity, limiting its widespread adoption. To address these issues, we propose investigating a modified protocol aiming to streamline the process and increase accessibility for transplantation centers globally.   Our research objectives are to demonstrate the safety and feasibility of an alternative DHOPE approach that eliminates the need for the perfusion fluid exchange. The exchange is deemed necessary because the red blood cells used during warm perfusion can not be used during hypothermic machine perfusion. Expected results include outcomes in safety and feasibility through pre-clinical studies on pig livers and validation with human research livers.

Cohosts Roslyn Mannon, MD and Josh Levitsky, MD are joined by Mackenzie Morris, MD to discuss the key articles of the July issue of the American Journal of Transplantation. https://lnkd.in/dcafHRRs [03:33] Biliary complications after adult-to-adult living-donor liver transplantation: An international multicenter study of 3633 cases https://lnkd.in/dczyw9Zi  [13:07] The impact of time to death in donors after circulatory death on recipient outcome in simultaneous pancreas-kidney transplantation https://lnkd.in/dMM6gsfF  [24:30] Should advanced perfusion be the standard of care for donation after circulatory death liver transplant? https://lnkd.in/dG4_N2G2  [32:20] Immunosuppression Withdrawal in Living-donor Renal Transplant Recipients Following Induction with Anti-thymocyte Globulin and Rituximab: Results of a Prospective Clinical Trial https://lnkd.in/dnyQTAT2  [40:30] Spatial multiomics of arterial regions from cardiac allograft vasculopathy rejected grafts reveal novel insights into the pathogenesis of chronic antibody-mediated rejection https://lnkd.in/dgVKdDrV  

Haploidentical bone marrow transplantation for AML in remission after TBF conditioning: a long-term follow-up Amazingly good outcomes DFS 75% at 10 yr Disease free and GVHD free survival 70% #PTCyRules #Haplo #AML The EBMT

In #lung transplantation, a short-term heparin-free anticoagulation strategy using #ECMO is safe and feasible perioperatively. Read More: https://bit.ly/3YgSl3p

Impact of CD34+ Graft Cell Dose on Outcomes after Haploidentical Bone Marrow Transplantation with Post-Transplant Cyclophosphamide-Based Gvhd Prophylaxis Blood (2024) 144 (Supplement 1): 3503 #ASH24

We all know anemia is a common disorder, but have you heard of Fanconi Anemia? Unlike typical anemia, Fanconi Anemia is a rare genetic condition that cannot be managed by medication. The only treatment option available is bone marrow transplant (BMT). However, the success of BMT depends on proper pre-transplant planning and post-transplant care. To learn more about Fanconi Anemia and bone marrow transplantation, check out my article published on Klarity. Thank you! https://lnkd.in/gznyfgsk

WEBINAR: Quality of Life after liver transplantation: An ESOT seminar for patients. ESOT - European Society for Organ Transplantation invite all Patients, Caregivers, Patient Advocates, and Representatives of Patient Associations and Organisations to their new Online Event: 𝗤𝘂𝗮𝗹𝗶𝘁𝘆 𝗼𝗳 𝗟𝗶𝗳𝗲 𝗔𝗳𝘁𝗲𝗿 𝗟𝗶𝘃𝗲𝗿 𝗧𝗿𝗮𝗻𝘀𝗽𝗹𝗮𝗻𝘁𝗮𝘁𝗶𝗼𝗻 - 𝗔𝗻 𝗘𝗦𝗢𝗧 𝗦𝗲𝗺𝗶𝗻𝗮𝗿 𝗳𝗼𝗿 𝗣𝗮𝘁𝗶𝗲𝗻𝘁𝘀. The upcoming seminar is organised by Teresa Antonini (France), Maria Speranta Iacob (Romania), Liz Schick (Switzerland) and Heiner Wedemeyer (Germany). Objectives of this seminar: • Identify key factors that significantly impact QOL after liver transplantation • Develop strategies and interventions aimed at improving QOL for liver transplant recipients (patient-centric strategies) • Promote multidisciplinary collaboration • Identify and enhance support systems • Use the findings to inform and refine clinical practices and healthcare policies Join ESOT for this insightful seminar to learn, share, and collaborate on improving the quality of life for liver transplant recipients. More details can be found here: #PoweredByESOT #transplantation #organdonation