Biomedicines MDPI’s Post

Join us for the upcoming Research Grand Rounds on 17 July to gain insights into “Neurogenetic and Rare Neurodegenerative Disorders: Clinical and Translational Updates”, organised by SingHealth Office of Research! Find out more information from the link in comments. #DukeNUS #AMRIevents #research #RGR #neurogenetic

I am pleased to share our latest publication in the Journal of Clinical Neuroscience: 📝 "Association of serum levels of inflammation and oxidative stress markers with cognitive outcomes in multiple sclerosis: A systematic review" In this study, we explored the link between inflammation, oxidative stress markers, and cognitive outcomes in multiple sclerosis. Understanding these associations can help pave the way for better clinical insights and therapeutic approaches. 🔗 Access the full article for free (valid until February 5, 2025) here: https://lnkd.in/dHmvtxac Thanks to my co-authors and everyone involved in making this research possible! #Research #MultipleSclerosis #CognitiveOutcomes #Inflammation #OxidativeStress

"Current clinical evidence suggests thiols and IL-17A as contributing factors in CI and TNF-α, IL-17A, IL-6, and CRP as factors linked with cognitive functions in MS. On the other side, IL-10, GPX, GSH, CAT, IMA, IL-8, IL-18, and IL-2 do not seem to affect cognition in MS. Also, evidence concerning the possible function of IFN-γ, TAC, and MDA in #cognitive deterioration of [people with #MultipleSclerosis] is conflicting. The complex and multifactorial nature of CI in MS necessitates further research to elucidate the underlying mechanisms and develop targeted interventions for cognitive rehabilitation in this population."

We are excited to share the news of our recently published article in ACS Chemical Neuroscience, titled "Unlocking the Potential of Oxymatrine: A Comprehensive Review of Its Neuroprotective Mechanisms and Therapeutic Prospects in Neurological Disorders." I extend my sincere appreciation to all co-authors for their valuable input. A special note of gratitude goes to our mentors, Dr. S.H Bodakhe and Dr. K.P Namdeo, for their steadfast support and scholarly contributions. This research offers an extensive examination of oxymatrine's neuroprotective mechanisms and potential, while highlighting the importance of ongoing research and development for its practical clinical use. As we continue our scientific exploration of this molecule, we aim to deliver meaningful results that will impact both healthcare and scientific communities. Interested readers can access the article at: DOI:10.1021/acschemneuro.4c00338 The authors would be pleased to provide a freely accessible link to this manuscript upon request. #ACSChemicalNeuroscience #Scientificpublishing #NeurologicalDisorders #GuruGhasidasVishwavidyalaya

Advancing Neuromuscular Research: Precision Measurement Techniques The O'Hara Wire Hanging Test Chamber sets a new standard for muscle strength evaluation in neuroscience research. Our FREE Application Note provides: • Validated protocols for consistent assessment • Expert tips for experimental design improvements  • Case studies from peer-reviewed publications Eliminate testing variability and enhance the rigor of your research. 📥 Download Application Note: https://lnkd.in/g8XRhzRQ #NeuroscienceResearch #ScientificMethodology #MuscleStrength #BreakthroughWithAmuza

[SSE#12] 🎤 Yesterday, Ruth SIMS, Postdoctoral Researcher at Inserm, Institut de la Vision (Inserm, CNRS - Centre national de la recherche scientifique, Sorbonne Université) presented an overview of the so-called “all-optical” approaches and how they have been successfully applied to answer some fundamental questions in neuroscience. 🙏 Thanks to her! #Twophotonmicroscopy #computergeneratedholography #temporalfocusing #optogenetics #voltageimaging

🤦🏽 It is regrettable that there are still medical colleagues with archaic arguments from the 1970s about the molecules of the sacred plant. 🇪🇸 At the symposium of the International Cannabinoid Research Society #ICRS2024 held in Salamanca, Spain, I had the opportunity to ask Dr. Javier Fernández-Ruiz, who has a PhD in biochemistry, his opinion about this doctor's arguments. 🧠 In addition to his teaching activities in the fields of Neurochemistry and Neurobiology, both at undergraduate and master's levels, he has been working for the last 39 years on various diseases of the central nervous system, having published 242 research articles and 44 review articles in international journals (H-index=69), 42 chapters in national and international books, and 8 international patents. 🫡 Science always seeks the truth; it is not something that should be used to reinforce moralistic and biased positions in search of views. 😬 #health #medicine #costarica #atrophy #brain #DrHernandez #science #mentalhealth #DrCarlos

Two recent Deallus blogs – written by Anna Scott, Ph.D., Deallus Senior Principal - explore the outlook for pharma’s prospects in neuroscience and why working in this therapeutic area is more exciting than ever. Read them here: https://lnkd.in/e8VPeG4M   While there remains an ongoing need for further research, a number of scientific breakthroughs in our understanding of the brain saw an uptick in investments in early-stage neuroscience drug programs in the late 2010s, bringing hope to millions of patients and their families whose lives are impacted by brain health conditions.      Neuroscience continues to be one of Deallus’ leading therapeutic areas, both in project volume and the expertise held by our consulting staff. We’ve had the privilege of partnering with many pharma organisations over the years as they navigate the challenges and complexities of drug development and commercialisation in neuroscience.    Read our blogs to find out more here: https://lnkd.in/e8VPeG4M   #blog #neuroscience #brainhealth #inspire #brainscience #sciencebreakthrough #expertise #brainawarenessweek #worldbrainday #advancements #equality #experience #leadingtheconversation

Neuroscientists have discovered brain cells that form multiple coordinate systems to tell us “where we are” in a sequence of actions. “Every day we solve new problems by generalising from our knowledge. Take cooking for example. When faced with a new recipe, you are able to use your background knowledge of similar recipes to infer what steps are needed, even if you have never made the meal before. We wanted to understand at a detailed cellular level how the brain achieves this and also to infer from this brain activity the algorithms being used to solve this problem,” - Dr Mohamady El-Gaby, first author on the study and postdoctoral neuroscientist in the Behrens lab at the Sainsbury Wellcome Centre at UCL and Nuffield Department of Clinical Neurosciences, University of Oxford. The new study, published in Nature Portfolio, helps us understand the algorithms used by the brain to flexibly generate complex behaviours, such as planning and reasoning. The findings may also be useful in understanding how such processes go wrong in conditions such as schizophrenia. Find out more ⬇️ https://lnkd.in/dqxw6rMh Image credit: Gil Costa #neuroscience

A Review in Nature Reviews Neuroscience reviews current and emerging methods for thalamic nuclei segmentation in neuroimaging data and considers the limitations of existing techniques in terms of their research and clinical applicability. 🔒 Read the article: https://lnkd.in/ehQbrAP6