Research Update: I'm thrilled to share my latest publication on the pharmacokinetics of imipramine in dogs! This study sheds light on the unique pharmacokinetic behavior of this tricyclic antidepressant in a canine model, with some key insights that could inform future clinical applications in veterinary medicine 🐾🩺 Among the key highlights: - Rapid Absorption: Imipramine showed a remarkably fast absorption rate, considerably quicker than in other species like humans and horses. - Short Terminal Half-Life: The drug exhibited a very short terminal half-life of only 0.25 hours, highlighting the challenge of sustaining therapeutic plasma concentrations over time. This suggests the need for more frequent dosing or alternative formulations to achieve prolonged effects. Additionally, it's important to note that imipramine's half-life in humans is around 18 hours, making direct extrapolation of human dosing regimens to dogs potentially risky, as once-daily administration would likely be insufficient to maintain therapeutic levels in dogs. - Species-Specific Metabolism: We observed the formation of the active metabolite desipramine, but interestingly, it was not quantifiable in plasma. This points to species-specific differences in the metabolism of imipramine, which could influence its therapeutic efficacy in dogs compared to other species, given that desipramine is an active metabolite in humans (equivalent additive effect on efficacy). - Fasting vs. Fed Conditions: No significant differences in pharmacokinetics were observed between fasted and fed states, indicating that imipramine's bioavailability in dogs may not be influenced by food intake—a key consideration for its clinical use. Given imipramine's brief presence in therapeutic plasma concentrations, we recommend further research into sustained-release formulations and the use of therapeutic drug monitoring to optimize its application in veterinary medicine!! #VeterinaryMedicine #Pharmacokinetics #Research #AnimalHealth #DrugDevelopment #VeterinaryPharmacology #Canines
Frane Božić
2mo
Bravo Nikola!
Business Communication & Human Resources Management
2moBravissimo 👏👏👏