CHOC Children's’ Post

📣Help Believe Big Spread the Word! Enroll in the MD Anderson Pediatric Mistletoe Trial II 🌱 ⭐Study #2022-0877: ISCADER P (MISTLETOE) Immunotherapy Trial ⭐To improve event-free survival in pediatric patients with relapsed osteosarcoma after resection of pulmonary metastases. This Phase II trial is led by Dr. Karen Moody at MD Anderson, with support from Dr. Katy Offer, a pediatric oncologist in New Jersey. Who Can Participate? ✅Ages 8-30 years old ✅Diagnosis of relapsed osteosarcoma ✅Undergone lung resection (surgery) About the Therapy: Participants will receive subcutaneous Iscador P (mistletoe) injections three times a week for 52 weeks. Please share this opportunity with anyone who might qualify. Together, we can advance treatment and provide hope to families. 🔗Learn more & sign up: https://loom.ly/FOlLYjU #MistletoeTherapy #Osteosarcoma #ClinicalTrial #MDAnderson #CancerResearch #HopeForOsteosarcoma #BelieveBig

tomorrow topic pediatric brain tumors updates

What are the benefits of stereotactic radiosurgery in pediatric care?💡 Join the upcoming RSS webinar with speaker Dr. Erin Murphy to learn about the roles and outcomes of cranial radiosurgery for benign and malignant brain tumors and AVMs. Supported by Elekta #SRS #GammaKnife #braincancer #avm

LONG-TERM outcomes following RADIOSURGERY for PEDIATRIC BRAIN AVMs: a systematic review Samuel D Pettersson et al., World Neurosurg, 2024 Mar https://lnkd.in/d8DrRjkA 1315 pediatric patients with AVMs treated withSRS - mean FOLLOW-UP period was 7 years (up to 23 YEARS) - AVM OBLITARATION observed in 66.1% - cumulative probabilities of AVM OBLITARATION were: *48.28% over 3 yrs *76.11% over 5 yrs *77.48% over 10 yrs - cumulative incidence of post-SRS HEMORRHAGE was 7.2% - cumulative incidence of post-SRS TUMORS was 0.3% - cumulative incidence of post-SRS CYST was 1.6% - cumulative incidence of post-SRS DENOVO SEIZURES was 1.5% - cumulative incidence of radiation induced NECROSIS was 8% - cumulative incidence of radiation induced EDEMA was 1.4% -cumulative incidence of RADIOLOGICAL RADIATION INDUCED CHANGES was 4.9% CONCLUSIONS: Current studies assessing long-term outcomes following SRS are moderate in quality and retrospective in nature. Thus, interpretation with caution is advised given the variable degree in loss to follow-up which suggests that complication rates may be higher than the values stated in the literature. #SRS #PediatricBrainAVM #AVMs

I’m excited to share insights into a compelling case report I’m currently working on—a story that highlights the power of perseverance in diagnosis and treatment. This case involves an 11-year-old female patient diagnosed with hepatoblastoma, a rare liver cancer typically found in children under the age of 3, accounting for only 1-2% of pediatric cancers globally. Initially, her symptoms led to a diagnosis of neuroblastoma. After she underwent multiple sessions of chemotherapy with no improvement, we decided to conduct further biopsies and radiologic studies. Through this process, we discovered her liver had become so massively enlarged that it occupied her entire abdominal area (as you see in the below picture)—a rare presentation for hepatoblastoma, as it’s usually a small tumor. With almost zero survival odds, our team consisting of experts in pediatrics oncology, proceeded with a high-risk, life-saving surgery. Thankfully, she made a remarkable recovery and is now on maintenance chemotherapy, resuming life as any child her age would. Stories like these remind us of the dedication required in healthcare to uncover the unexpected and deliver hope against the odds. Stay tuned for the publication of the full case report—I look forward to sharing more insights soon! #Hepatoblastoma #PediatricOncology #CaseReport #HealthcareInnovation #ChildHealth

What are the benefits of radiosurgery and stereotactic body radiotherapy in pediatric care?💡 Join the upcoming RSS webinar with speaker Dr. Erin Murphy to learn about the roles and outcomes of cranial radiosurgery for benign and malignant brain tumors and AVMs. Supported by @Elekta. #SRS #GammaKnife #braincancer #avm

Utility of Indocyanine Green for Sentinel Lymph Node Biopsy in Pediatric Sarcoma and Melanoma Indocyanine green (ICG) is a fluorescent dye with increasing use for adult sentinel lymph node biopsy (SLNB). The utility of ICG in pediatric oncology remains understudied. We aim to describe our experience using ICG for SLNB in pediatrics versus standard blue dye. A retrospective review of pediatric patients with melanoma or sarcoma who underwent SLNB with technetium plus ICG or blue dye from 2014 to 2023 at a large academic children's hospital was conducted. Results: Twenty-four patients were included; 58.3% were male with median age 13 years (range 4-21 years). The majority had a melanocytic tumor (91.7%) and 8.3% had sarcoma. All patients received technetium with concomitant blue dye (62.5%) or ICG (37.5%). ICG more reliably identified radioactive SLNs, compared to blue dye (mean 100% vs 78.3 ± 8.3%, p = 0.03). There was no significant difference in median operative time (ICG 82 min [68-203] vs blue dye 93 min [78-105], p = 0.84). Seven patients had positive SLNs (29.2%), with recurrence in 2 patients (8.3%) and 1 death (4.2%). There were no adverse events. Conclusion: ICG-directed SLNB in children is a safe and effective alternative to blue dye. Use of ICG did not add to operative time, and more often identified sentinel nodes versus blue dye. https://lnkd.in/eEVN87hP Paolo D A Vignali, Brittani Kn Seynnaeve, Alexander J Davit 3rd, Kurt Weiss Insiyah Campwala Marcus Malek #ICG #indocyaninegreen #guidedsurgery #fluorescence #fluorescent #surgery #surgeon #surgical #thinkgreen #imaging #patients #safety #pediatric

What are the benefits of radiosurgery and stereotactic body radiotherapy in pediatric care?💡 Join the upcoming RSS webinar with speaker Dr. Erin Murphy to learn about the roles and outcomes of cranial radiosurgery for benign and malignant brain tumors and AVMs. Supported by @Elekta. #SRS #GammaKnife #braincancer #avm

What are the benefits of radiosurgery and stereotactic body radiotherapy in pediatric care?💡 Join the upcoming RSS webinar with speaker Dr. Erin Murphy to learn about the roles and outcomes of cranial radiosurgery for benign and malignant brain tumors and AVMs. Supported by @Elekta. #SRS #GammaKnife #braincancer #avm

What are the benefits of radiosurgery and stereotactic body radiotherapy in pediatric care?💡 Join the upcoming RSS webinar with speaker Dr. Erin Murphy to learn about the roles and outcomes of cranial radiosurgery for benign and malignant brain tumors and AVMs. Supported by @Elekta. #SRS #GammaKnife #braincancer #avm