Journal Biology of the Cell’s Post

📜 Inheritance of Mitochondria in Pelargonium Section Ciconium (Sweet) Interspecific Crosses, by Floris Breman, Eric Schranz, and Freek T. Bakker, et al. Wageningen University & Research 🔗 https://lnkd.in/g6uC6RQt #pelargonium #mitochondrion #inheritance #ciconium

It is appealing to view this graphical abstract: Umbilical Cord Blood-Derived Monocytes as A Reliable Source of Functional Macrophages for Biomedical Research DOI: 10.22074/CELLJ.2023.1990203.1238 Authors: Shukoofeh Torabi; Morteza Zarrabi; Nikoo Hossein-Khannazer; Majid Lotfinia; Masoumeh Nouri; Roberto Gramignoli; Moustapha Hassan; Massoud Vosough More information: https://lnkd.in/dNaPKXDb #monocyte #Blood #macrophage #biomedical #cord #umbilical

A new manuscript from the Parker Lab on the regulation of SLC4A11, the black sheep of the SLC4A family, in our Advances in Acid-Base Physiology: From Single Transporters to Physiology research topic: NH3/NH4+ allosterically activates SLC4A11 by causing an acidic shift in the intracellular pK that governs H+(OH−) conductance The topic is still accepting manuscripts. https://lnkd.in/gWGJpnbF

Glyoxal acid-free (GAF) histological fixative is a suitable alternative to formalin: results from an open-label comparative non-inferiority study

#D-dimer is the gold standard biomarker of coagulation activation and secondary fibrinolysis. A new review explores the physiology and physiopathology of D-dimer formation and summarizes the main conditions associated with increased D-dimer, while proposing a new approach to their management. https://lnkd.in/d7CUXAh3

Mitochondria, essential for oxidative phosphorylation and other cellular functions, have ~1,000–1,500 proteins, 99% synthesized by cytosolic ribosomes and imported as precursors via the TOM complex in the outer membrane. This study presents cryo-EM structures of the TOM complex from Saccharomyces cerevisiae, with the dimeric form at 3.1-Å and the tetrameric form at 4.1-Å resolution. The dimeric TOM comprises two copies each of five proteins, including the pore-forming Tom40 and four auxiliary transmembrane proteins. The tetramer structure (PDB: 6UCV), a dimer of dimeric TOM, reveals the detailed molecular organization of the TOM complex, providing insights into the mechanism of protein translocation into mitochondria.  Rendering by Suhaila Rahman (@sophie.rheave) made with #ProteinImager 3D view https://lnkd.in/dxwtkns4 #sciart #cryoem #molecularart #structuralbiology #mitochondria #yeast #TOMcomplex

Mitochondria, essential for oxidative phosphorylation and other cellular functions, have ~1,000–1,500 proteins, 99% synthesized by cytosolic ribosomes and imported as precursors via the TOM complex in the outer membrane. This study presents cryo-EM structures of the TOM complex from Saccharomyces cerevisiae, with the dimeric form at 3.1-Å and the tetrameric form at 4.1-Å resolution. The dimeric TOM comprises two copies each of five proteins, including the pore-forming Tom40 and four auxiliary transmembrane proteins. The tetramer structure (PDB: 6UCV), a dimer of dimeric TOM, reveals the detailed molecular organization of the TOM complex, providing insights into the mechanism of protein translocation into mitochondria.  Rendering by Suhaila Rahman (@sophie.rheave) made with #ProteinImager 3D view https://lnkd.in/d5WDHZQK #sciart #cryoem #molecularart #structuralbiology #mitochondria #yeast #TOMcomplex

Who doesn’t like spicy food? How do you feel when you accidentally bite into a hot chili? The burning sensation comes from capsaicin, a compound that induces thermogenesis, tricking our body into thinking it's experiencing a real burn. Capsaicin, part of the vanilloid family, binds as an agonist to the TRPV1 receptor, a transmembrane ion channel. TRPV1 is also stimulated by temperature changes, pH changes, physical abrasion, and endogenous lipids. When activated, it starts a depolarization cascade, allowing sodium and calcium ions to flow in. Molecular dynamics simulations revealed that capsaicin can flip from extracellular to intracellular, entering the TRPV1 binding site. In mammals, high temperature detection is carried out by primary afferent neurons expressing TRP channels. Some species, like the 13-lined ground squirrel, have evolved to withstand high environmental heat by modifying TRPV1.  TRP channels are polymodal molecular sensors involved in many physiological processes and human diseases. Here, the structure of the full-length thirteen-lined ground squirrel TRPV1 in complex with capsaicin, solved by cryo-EM, reveals how the S5-P-loops form an extracellular cap domain critical for channel conductance, open probability, and ion selectivity. The C-terminus of TRPV1 stabilizes the intracellular skirt through numerous interactions. Given their role in various physiological and pathophysiological processes, TRPV channels are promising drug targets. (PDB:7LR0) Rendering by Suhaila Rahman (@sophie.rheave) made with #proteinimager 3D view: https://lnkd.in/dHNpF3xT #sciart #cryoem #ionchannel #capsaicin #TRPV1 #structuralbiology #molecularart

RBC.....a circular,biconcave,non nucleated after maturation. Shape of RBC is maintained by Spectrin ,Ankyrin and physiology is maintained by 1.GLUT1 2.BAND 3 3.SIALIC ACID 4.NADPH 5.BAND 7 Pannexin and stromatin regulate channel protein functions. and many more

Lovely new review article from John E. Walker of the MRC Mitochondrial Biology Unit detailing 5 decades of work to understand the pathophysiology of Citrin metabolism and how this leads to the varied picture observed in Citrin Deficiency. Read 👉🏻 https://lnkd.in/epsv4vg4 Commissioned for the imminent special issue Ureagenesis Defects: Novel Models and Treatment Options My path to citrin deficiency John E. Walker Citrin Foundation #citrindeficiency