Cell Journal yakhteh’s Post

A new manuscript from the Parker Lab on the regulation of SLC4A11, the black sheep of the SLC4A family, in our Advances in Acid-Base Physiology: From Single Transporters to Physiology research topic: NH3/NH4+ allosterically activates SLC4A11 by causing an acidic shift in the intracellular pK that governs H+(OH−) conductance The topic is still accepting manuscripts. https://lnkd.in/gWGJpnbF

Congratulations to Dr. NISHTHA CHANDAL, Dr. Ritu Kalia, Ph.D., Akash Dey, Dr. Rushikesh Tambat, Dr. Nisha Mahey, PhD, Prof. (Dr.) Sanjay Jachak, and Dr. Hemraj Nandanwar on their publication titled "𝐒𝐲𝐧𝐭𝐡𝐞𝐭𝐢𝐜 𝐢𝐧𝐝𝐨𝐥𝐞 𝐝𝐞𝐫𝐢𝐯𝐚𝐭𝐢𝐯𝐞𝐬 𝐚𝐬 𝐚𝐧 𝐚𝐧𝐭𝐢𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐚𝐥 𝐚𝐠𝐞𝐧𝐭 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐢𝐧𝐠 𝐫𝐞𝐬𝐩𝐢𝐫𝐚𝐭𝐨𝐫𝐲 𝐦𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐬𝐦 𝐨𝐟 𝐦𝐮𝐥𝐭𝐢𝐝𝐫𝐮𝐠-𝐫𝐞𝐬𝐢𝐬𝐭𝐚𝐧𝐭 𝐠𝐫𝐚𝐦-𝐩𝐨𝐬𝐢𝐭𝐢𝐯𝐞 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐚" in Communications Biology (Nature, Impact Factor: 5.2)! 🎉 This remarkable study presents two new antibacterials, SMJ-2 and SMJ-4, found fortuitously while screening for efflux pump inhibitors for the NorA efflux pump in S. aureus. This identifies SMJ-2 and SMJ-4 as potential solutions against multidrug-resistant gram-positive bacteria, with SMJ-2 proving more active. SMJ-2 uniquely inhibits respiratory metabolism, disrupts membrane potential, and targets the mevalonate pathway, blocking antioxidant synthesis and enabling pathogen destruction by phagocytic cells. Importantly, it exhibits a strong safety profile, with no significant toxicity observed in mouse models. 📄 Read the full paper here: https://lnkd.in/gvU8bCu5 #ResearchExcellence #AntibioticResistance #DrugDiscovery #CommunicationsBiology #Nature #NIPERM #DONP

PRP is a therapy produced from the patient's own blood that is made up of plasma and a high concentration of platelets. It is injected into the injured area, thereby introducing a high concentration of platelets (as well as growth factors and cytokines) to the injury site, helping it heal. Platelets are well-known for their clotting abilities, but they also contain growth factors that can trigger cell reproduction and stimulate tissue regeneration or healing in the treated area. Platelet-rich plasma is simply blood that contains more platelets than normal. Visit us for more information : https://lnkd.in/gHHWFg4m Submissions are Open in the broad scope of the Journal of Regenerative Biology and Medicine [ISSN: 2582-385X]. Authors can directly submit their manuscripts to regenerativeBiol@maplejournal.com Source: Internet. #tissues #regeneration #plateletrichplasma #growth #cytokines

Who doesn’t like spicy food? How do you feel when you accidentally bite into a hot chili? The burning sensation comes from capsaicin, a compound that induces thermogenesis, tricking our body into thinking it's experiencing a real burn. Capsaicin, part of the vanilloid family, binds as an agonist to the TRPV1 receptor, a transmembrane ion channel. TRPV1 is also stimulated by temperature changes, pH changes, physical abrasion, and endogenous lipids. When activated, it starts a depolarization cascade, allowing sodium and calcium ions to flow in. Molecular dynamics simulations revealed that capsaicin can flip from extracellular to intracellular, entering the TRPV1 binding site. In mammals, high temperature detection is carried out by primary afferent neurons expressing TRP channels. Some species, like the 13-lined ground squirrel, have evolved to withstand high environmental heat by modifying TRPV1.  TRP channels are polymodal molecular sensors involved in many physiological processes and human diseases. Here, the structure of the full-length thirteen-lined ground squirrel TRPV1 in complex with capsaicin, solved by cryo-EM, reveals how the S5-P-loops form an extracellular cap domain critical for channel conductance, open probability, and ion selectivity. The C-terminus of TRPV1 stabilizes the intracellular skirt through numerous interactions. Given their role in various physiological and pathophysiological processes, TRPV channels are promising drug targets. (PDB:7LR0) Rendering by Suhaila Rahman (@sophie.rheave) made with #proteinimager 3D view: https://lnkd.in/d8k2GJ2E #sciart #cryoem #ionchannel #capsaicin #TRPV1 #structuralbiology #molecularart

Who doesn’t like spicy food? How do you feel when you accidentally bite into a hot chili? The burning sensation comes from capsaicin, a compound that induces thermogenesis, tricking our body into thinking it's experiencing a real burn. Capsaicin, part of the vanilloid family, binds as an agonist to the TRPV1 receptor, a transmembrane ion channel. TRPV1 is also stimulated by temperature changes, pH changes, physical abrasion, and endogenous lipids. When activated, it starts a depolarization cascade, allowing sodium and calcium ions to flow in. Molecular dynamics simulations revealed that capsaicin can flip from extracellular to intracellular, entering the TRPV1 binding site. In mammals, high temperature detection is carried out by primary afferent neurons expressing TRP channels. Some species, like the 13-lined ground squirrel, have evolved to withstand high environmental heat by modifying TRPV1.  TRP channels are polymodal molecular sensors involved in many physiological processes and human diseases. Here, the structure of the full-length thirteen-lined ground squirrel TRPV1 in complex with capsaicin, solved by cryo-EM, reveals how the S5-P-loops form an extracellular cap domain critical for channel conductance, open probability, and ion selectivity. The C-terminus of TRPV1 stabilizes the intracellular skirt through numerous interactions. Given their role in various physiological and pathophysiological processes, TRPV channels are promising drug targets. (PDB:7LR0) Rendering by Suhaila Rahman (@sophie.rheave) made with #proteinimager 3D view: https://lnkd.in/dHNpF3xT #sciart #cryoem #ionchannel #capsaicin #TRPV1 #structuralbiology #molecularart

🌟#notablepaper on Reactive Oxygen Species 📚Biological Consequences of Vanadium Effects on Formation of Reactive Oxygen Species and Lipid Peroxidation 🔗https://lnkd.in/ghF7DuYF 👨🔬By Prof. Manuel Aureliano et al MDPI Universidade do Algarve Colorado State University Algarve Biomedical Center - ABC #reactiveoxygenspecies #ROS #lipidperoxidation #vanadium #decavanadate #oxidativestress #radicals #mitochondria

🔬 New Research on cardiac troponins 🔬 The impact of commonly used anticoagulants such as sodium citrate, heparin and EDTA, on the integrity of the ITC-complex in the samples remains unclear. 🧑🔬 To address this, Hytest scientists have conducted extensive studies – with the results compiled in our latest article published in the International Journal of Molecular Sciences.   ➡️ Read more and stay ahead of the curve in cardiac diagnostics: https://lnkd.in/dkDWkCnN   #IVD #CardiacDiagnostics #Troponins #ClinicalLabs #antibody

Well done, Federico Herrera, group leader of the Cell Struture and Dynamics Lab from BioISI - Biosystems & Integrative Sciences Institute - Faculdade de Ciências da Universidade de Lisboa, for the two grants awarded by Ataxia UK, to study two specific types of ataxias - an umbrella term for a group of rare neurological disorders that affect balance, coordination and speech According to Federico: "These funds will allow us to shed light on two rare disorders with little interest to pharma industry, but that constitute two scientific and biotechnological challenges of the highest rank" Know more on our webiste: https://bioisi.pt/news/74 #bioisinews #sciencegoals #research #raredisease #Ataxia #ataxiacerebelar

Mitochondria are way-cool https://lnkd.in/geuw3_s7

The combination of Fura-2 and ING-2 were used to measure cation permeability of ligand gated channels in this exceptional manuscript from researchers Sapienza Università di Roma. According to the authors - “Excessive calcium influx through N-methyl-D-aspartate type glutamate receptors (NMDAR) is associated with excitotoxicity and neuronal death, but the inhibition of this receptor-channel causes severe adverse effects. Thus, a selective reduction of NMDA-mediated Ca2+ entry, leaving unaltered the Na+ current, could represent a valid neuroprotective strategy.” - and they discovered a negative allosteric modulator of NMDARs that can achieve just that! Read more about their exciting research - https://lnkd.in/gCUtG6hp #fluorescence #innovation #multiplexing #ionchannels #drugdiscovery