Julian TSCHOLLAR’s Post

📢 Excited to share our latest publication from DECISION members, where we developed a fast and reproducible animal model of advanced MASH-cirrhosis in rats. By using a combination of CCl4, a high-fat Western diet (WD), and phenobarbital (PB), we've been able to mimic the key histological and pathophysiological features of decompensated MASH-cirrhosis seen in humans. 🔬 In just a shorter timeframe compared to existing models, this approach accurately reflects the advanced stage of the disease, making it an excellent tool for the development of new pharmacological treatments for MASH-cirrhosis. For more details, read the full paper here: 🔓 https://lnkd.in/dGs6TQS6 Special thanks to MDPI OpenAccess! Congrats to first authors Nico Kraus and Frank Erhard Uschner, as well as all contributing authors: Magnus Möslein, Robert Schierwagen, Wenyi Gu, Maximilian Brol, Elke Fürst, Inga Grünewald, Sophie Lotersztajn, Pierre-Emmanuel Rautou, Marta Duran Güell, PhD, Roger Flores Costa, Joan Claria, Jonel Trebicka, and Sabine Klein MedB LAB EASL | The Home of Hepatology European Foundation for the Study of Chronic Liver Failure (EF CLIF) #LiverResearch #Cirrhosis #MASH #Hepatology #DrugDevelopment #LiverDisease #AnimalModels #LiverHealth

in our recent paper we describe why #phages can help in managing #asthma through the #microbiome. The CURE Project https://lnkd.in/dEVTN5Ax

Today we celebrate World Celiac Day, an important occasion to reflect on advancements in the diagnosis and treatment of this condition. 🇮🇹 In Italy, we take pride in being at the forefront thanks to the new law implementing screening for celiac disease across the pediatric population. ⚖️ The recent Italian legislation has been recognized as a significant step towards promoting public health. In this innovative light, IVY Diagnostics offers advanced solutions for rapid diagnosis, including the Biocard™ Celiac Test: https://lnkd.in/dB_JKM65 This lateral flow immunochromatographic test provides a qualitative assessment of anti-tissue transglutaminase IgA antibodies in just 10 minutes, with only a drop of blood from the fingertip. Additionally, the professional version of the test includes a system for measuring total IgA, thus reducing the risk of false negatives due to IgA deficiency. We are excited to be part of this progress towards swifter and more accurate diagnosis of celiac disease, contributing to improving the quality of life for those living with this condition. #WorldCeliacDay #RapidDiagnosis #ItalianLaw #IVYDiagnostics #Coeliac (photo credit to Association of European Coeliac Societies )

Interested in the natural roles and potential of phages in asthma? Have a read of this interesting paper from our our leading lung microbiome expert within the Leicester Centre for Phage Research at the University of Leicester 🙂

Unraveling IFN-I response dynamics and TNF crosstalk in the pathophysiology of systemic lupus erythematosus https://lnkd.in/g78JgU3v

Liver scarring, known as fibrosis, is a major health issue which can progress into non-alcoholic fatty liver disease and eventually cirrhosis. Liver cirrhosis alone causes roughly one million deaths every year. Research into the causes of liver fibrosis has heavily relied on rodents like rats and mice. However, significant differences between the species mean the translation of research findings from animal experiments into treatments for humans has repeatedly failed. FRAME lab Alumni Dr Syedia Rahman investigated methods to prevent liver fibrosis using lab-grown human liver cells. Her innovative techniques hold promise for replacing animal experiments and accelerating the development of treatments for patients. https://lnkd.in/ewSE2JBj

What's new in the field of monoamine oxidases, mitochondria and inflammation ? 🤔 Check out our last review recently published in Redox Biology ! 😊 🔬 #mitochondria #inflammation #mitoDAMPs #monoamineoxidases

‘Do you have a tapeworm?’ I used to hear my grandmother say when I woke up with a big appetite as a child. It is also because of this memory that I am very happy to finally see published in BioEssays Journal this work done with Ingrid Lamminpää and Amedeo Amedei, whom I thank once again for the opportunity to work together. In this work we explore the potential therapeutic use of certain parasitic worms. We also have a symbiotic relationship with these animals that has not always been observed from perspectives other than purely aetiopathogenic ones. After analysing the role of worms in relation to human health from the point of view of their symbiotic and evolutionary relationship, we try to make a critical assessment of some recent studies on their possible therapeutic applications. In doing so, we focus on some important mechanisms of action and potential benefits, but we also point out the exaggerations and over-enthusiasm of these novelties, and examine the theoretical and methodological difficulties of such proposals. Since these approaches are still in an embryonic stage, we conclude by advocating the need to produce new and further studies to fully explore all aspects of this perspective and encourage the scientific community to do so. https://lnkd.in/duQ5aJJW

Latest technology can be a game changer in identification of specific cell populations in pancreas and research focus for pancreatic cancer and diabetes.

📢 New August release! 📢 Exploring the non-biopsy strategy for diagnosing Celiac Disease in adults. 🩺📊 This narrative review dives into the latest evidence, pros, and cons of relying on serology without duodenal biopsy. A must-read for those following the evolving guidelines! 🌾 👉 https://lnkd.in/dCeFeubA #TurkishJournalofGastroenterology #TJG #GastroenterologyResearch #MedicalJournals #GastrointestinalResearch #August #NewIssue #MedicalResearch #Gastrointestinaltract #CeliacDisease