An article from the New Scientist highlights promising research led by Moderna on an investigational mRNA vaccine for mpox. While existing vaccines are already available and effective, this new mRNA approach has shown potential advantages in early animal trials. However, it’s important to note that this vaccine is still investigational, and more research is needed to confirm its effectiveness in humans. This development highlights the importance of mRNA technology in tackling emerging health threats. https://lnkd.in/eyceysMh #mRNA #VaccineDevelopment #PublicHealth #Research
Luke Mircea-Willats’ Post
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I am excited to have completed a 2-day INTRODUCTORY mRNA VACCINE DESIGN AND DEVELOPMENT course organized by Helix Biogen Institute. mRNA vaccines are novel vaccines that work by directly delivering mRNA, encoding the specific protein antigen associated with a particular disease. As compared to traditional vaccines, they are safe and flexible, can be rapidly developed as well as induce robust immune responses. The mRNA vaccine course exposed me to bioinformatics and artificial intelligence as important tools in the design of mRNA vaccines. I look forward to more training from Helix Biogen Institute on vaccine design and development. Special thanks to the facilitator Dr. Oladipo Elijah Kolawole (Ph.D) and his team for such a wonderful delivery! #mRNAVaccines #Bioinformatics #Vaccines #VaccineDesign #VaccineDevelopment #OneHealth #AfricanUnion #GlobalHealth
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mRNA vaccines represent a groundbreaking advancement in modern medicine. mRNA, or messenger RNA, was discovered in the early 1960s, but it wasn't until the early 1990s that its potential as a therapeutic tool was proposed. This was mainly due to the challenges concerning its effective delivery. However, the development of lipid nanoparticles (LNPs) transformed this landscape. mRNA enclosed in these LNPs could enter cells and instruct cells to produce pathogen-specific proteins or antigens. These antigens trigger an immune response, training the body to recognize and combat the actual infections. The efficacy of mRNA vaccines, especially in combating COVID-19, highlights their potential to treat a range of diseases signaling the beginning of a new chapter in the history of preventative healthcare. #mRNA #Biotechnology #LipidNanoparticles #Vaccines #RNAtherapeutics #Microfluidics #Covid19
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| #TRONpublication | RNA-based #vaccines are technologies which have been already proven successful during the pandemic, but have we fully realized their application potential? 🧬💉 What types of #RNA vaccines exist, how do they work and how can we enhance them? These are questions which have been addressed in the review authored by Aysegül Yildiz, Cristian Raileanu and Tim Beissert titled “Trans-Amplifying RNA: A Journey from Alphavirus Research to Future Vaccines”, which has been recently published in the Special Issue Self-Replicating RNA Viruses of the #VirusesJournal. Beginning with the role of transreplicon RNA in alphavirus research, the authors explain and highlight the potential benefits of trans-amplifying RNA for advancing the next generation of RNA-based vaccines. Interested? Take a look at the article: 👉https://lnkd.in/eTyCxgyZ #TRONMainz #publication #mdpi
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Read this before you make your next RNA vaccine!
Computational design of mRNA vaccines
sciencedirect.com
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🚨 Let's talk Mpox with Kling Biotherapeutics 🚨 In a fresh-off-the-press📰editorial in pharmaphorum, Kling Biotherapeutics Chief Scientific Officer, Stefano Gullà discusses how new approaches in #antibody research technology could halt the rapid spread of #Mpox and other #outbreaks. “I’m confident that today we have the technology to quickly respond to emerging pandemic threats to bring lifesaving antibody drugs to patients – it’s only a matter of time before a new disease threat emerges that requires global action.” said, Stefano. As global concerns rise about the speed of the life science industry’s response to emerging pandemics threats, #Kling is leading the charge with its cutting-edge clinically validated discovery platform that identifies novel therapeutic targets🎯and #antibody binders derived from #Bcells of patients with exceptional clinical responses. By pairing its novel target discoveries with antibody engineering from its expert drug developers, Kling is well poised to develop the next generation of therapeutic #antibodies to face global outbreaks head-on. Read the full article here👉https://bit.ly/47VbGvE Follow #KlingBio on LinkedIn and X / Twitter @KlingBio_ to stay up to date on how the company is revolutionizing #antibodytherapeutics. #infectiousdiseases #drugdiscovery #immunooncology #drugdevelopment
Mpox shows need for new approaches to therapeutic antibody research
pharmaphorum.com
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As a virologist dedicated to combating RSV and influenza, I'm excited to share how the NanoAssemblr® @Spark™ is contributing to our vaccine research! Nucleic acid vaccines based on mRNA were conceived more than three decades ago; however mRNA was not used as a therapeutic tool because of less stability, poor efficacy, and excessive immunostimulation. @NanoAssemblr® Spark™ technology is transforming vaccinology and biomedical sciences! It allows precise and efficient mRNA encapsulation, an essential component of our vaccines. Why Lipid Nanoparticles? The lipid nanoencapsulation can protect mRNA from the RNAse enzyme, which is present in abundance throughout the body and can disintegrate mRNA almost instantly upon contact. ✔It Maintains mRNA stability. The @Spark™ excels in shielding fragile mRNA molecules from degradation, ensuring their integrity during storage and delivery. ✔ Lipid nanoparticles are ideal for delivering mRNA into target cells, initiating the production of viral antigens without causing disease. It involves the usage of our required mRNA , formulation buffer 1 & 2 and the lipid nanoparticle we are using. After encapsulation , the Ribogreen Assay is performed to measure the concentration of the encapsulated mRNA. Follow ⚜ Surya Sekhar Pal ⚜ for more! #mRNA #vaccine #vaccinetechnology #vaccinestudies #RSV #influenza #respiratory #diseases #linkedinfamily #linkedinforcreators #sciencecommunication #encapsulation #lipidnanoparticles #research #researchanddevelopment #followformore #industries #pharmaindustries #pfizer #followus
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🎓 Scientific Highlight of the Week 🎓 We are delighted to share insights from a brand-new study entitled "Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting" published in J. Exp. Med by Raphaël Jeger-Madiot et al: https://lnkd.in/dydxf_Rw Congratulations to all authors for this impressive study. They developed a lymphoid organ-chip (LO chip) model to predict the immunogenicity of candidate vaccines and demonstrated that the LO chip represents a versatile platform suited to the preclinical evaluation of vaccine-boosting strategies. Our LNP formulations engineered with a “Moderna-like” lipid composition and encapsulating mRNA encoding for GFP ad Ovalbumine were used as controls. Raphaël Jeger-Madiot, Delphine Planas, isabelle STAROPOLI, Hippolyte Debarnot, Jérôme Kervevan, Héloïse MARY, Camilla Collina, Barbara Fonseca, Rémy ROBINOT, Stacy Gellenoncourt, Olivier Schwartz, Lorna Ewart, Michael Bscheider, Lisa Chakrabarti #mRNA, #vaccine, #immunology, #LNP, #immunization, #chips, #lymphoidorganchip
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting
rupress.org
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🚀 Momentum in Animal mRNA Vaccine Research, But Challenges Persist 💪 Animal mRNA vaccine research is gaining strong momentum, but it also faces a number of challenges. On the technical front, one of the key issues is that the immune protection induced by several mRNA vaccine candidates is still not as robust as that of traditional inactivated vaccines. To address this, there is a pressing need to optimize mRNA vaccine designs, particularly in improving the translation control within target cells. At YXgene, we are committed to advancing mRNA vaccine technology. We proudly offer mRNA vaccine design services. With our expertise and innovative solutions, we help tackle these technical challenges, driving faster and more efficient development of animal mRNA vaccines. Let's collaborate to unlock the full potential of animal mRNA vaccines and bring cutting-edge solutions to the market! 👏 ✨ #mRNA #AnimalVaccines #VaccineDevelopment #Biotech #Innovation #Healthcare #mRNATechnology #VaccineResearch
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