Nick Hand’s Post

An article from the New Scientist highlights promising research led by Moderna on an investigational mRNA vaccine for mpox. While existing vaccines are already available and effective, this new mRNA approach has shown potential advantages in early animal trials. However, it’s important to note that this vaccine is still investigational, and more research is needed to confirm its effectiveness in humans. This development highlights the importance of mRNA technology in tackling emerging health threats. https://lnkd.in/eyceysMh #mRNA #VaccineDevelopment #PublicHealth #Research

In this article, originally published in The Conversation US, Angie Hilliker answers the question: "What does mRNA do?" and discusses #mRNA vaccines beyond COVID-19: https://lnkd.in/eKqKVPT9. #WorldRNADay (4/5)

🚀 Momentum in Animal mRNA Vaccine Research, But Challenges Persist 💪 Animal mRNA vaccine research is gaining strong momentum, but it also faces a number of challenges. On the technical front, one of the key issues is that the immune protection induced by several mRNA vaccine candidates is still not as robust as that of traditional inactivated vaccines. To address this, there is a pressing need to optimize mRNA vaccine designs, particularly in improving the translation control within target cells. At YXgene, we are committed to advancing mRNA vaccine technology. We proudly offer mRNA vaccine design services. With our expertise and innovative solutions, we help tackle these technical challenges, driving faster and more efficient development of animal mRNA vaccines. Let's collaborate to unlock the full potential of animal mRNA vaccines and bring cutting-edge solutions to the market! 👏 ✨ #mRNA #AnimalVaccines #VaccineDevelopment #Biotech #Innovation #Healthcare #mRNATechnology #VaccineResearch

| #TRONpublication | RNA-based #vaccines are technologies which have been already proven successful during the pandemic, but have we fully realized their application potential? 🧬💉 What types of #RNA vaccines exist, how do they work and how can we enhance them? These are questions which have been addressed in the review authored by Aysegül Yildiz, Cristian Raileanu and Tim Beissert titled “Trans-Amplifying RNA: A Journey from Alphavirus Research to Future Vaccines”, which has been recently published in the Special Issue Self-Replicating RNA Viruses of the #VirusesJournal. Beginning with the role of transreplicon RNA in alphavirus research, the authors explain and highlight the potential benefits of trans-amplifying RNA for advancing the next generation of RNA-based vaccines. Interested? Take a look at the article: 👉https://lnkd.in/eTyCxgyZ #TRONMainz #publication #mdpi

This article provides a clear explanation of mRNA vaccine research 101.

Which vaccines use cell culture for production Attenuated rubella vaccine: The current rubella vaccine uses the BRD-II attenuated strain, which was isolated from a throat swab specimen of a typical rubella patient, and was passaged and cultured in diploid cells. When the virus reproduction reached its peak, the vaccine liquid was harvested and freeze-dried after passing the test. Measles vaccine: The measles vaccine is made by inoculating chicken embryo cells with the attenuated measles virus strain, culturing and harvesting the virus liquid, and then freeze-drying. Hepatitis A vaccine: The live vaccine is made by inoculating the attenuated hepatitis A virus strain (H2 strain) into human diploid cells, culturing and harvesting the virus. The inactivated vaccine is prepared using the inactivated hepatitis A virus (HM175 virus strain). #vaccine #biological #biotechnology #cellculture https://lnkd.in/ehJakRCN

What the hell is N1-Methyl-Pseudo-Uridine and what is it doing in my body you might ask. Well, it turns out that in order to prevent our intra-cellular TLRs from detecting the mRNA in the Covid-19 vaccines they replaced Uridine with N1-Methly-Pseudo Uridine. Normally, the mRNA from mRNA viruses is detectably different from the mRNA we produce (in the nucleuses of our cells) and we have mechanisms to detect viral mRNA and degrade it. That makes sure the modRNA survives long enough, or perhaps a lot longer than expected, but may cause other issues. That is what this paper is about. https://lnkd.in/ghMJcujt

Always inspiring to see advancements in Clinical Research. A recent study published in Molecular Therapy – Methods & Clinical Development highlights advancements in mRNA vaccine technology. Researchers have developed an mRNA-based vaccine candidate, mRNA RBD-TM, designed to address the phenomenon of "immune imprinting" seen with certain vaccines. This development could represent an important step forward in enhancing immune responses against emerging viral strains. We believe in the importance of sharing knowledge that drives innovation across the healthcare industry. Advancements like these are crucial as we collectively work toward improving health outcomes for all. #ClinicalResearch #Innovation #VaccineDevelopment https://lnkd.in/ecQb5Fqt

🎓 Scientific Highlight of the Week 🎓 We are delighted to share insights from a brand-new study entitled "Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting" published in J. Exp. Med by Raphaël Jeger-Madiot et al:  https://lnkd.in/dydxf_Rw Congratulations to all authors for this impressive study. They developed a lymphoid organ-chip (LO chip) model to predict the immunogenicity of candidate vaccines and demonstrated that the LO chip represents a versatile platform suited to the preclinical evaluation of vaccine-boosting strategies. Our LNP formulations engineered with a “Moderna-like” lipid composition and encapsulating mRNA encoding for GFP ad Ovalbumine were used as controls. Raphaël Jeger-Madiot, Delphine Planas, isabelle STAROPOLI, Hippolyte Debarnot, Jérôme Kervevan, Héloïse MARY, Camilla Collina, Barbara Fonseca, Rémy ROBINOT, Stacy Gellenoncourt, Olivier Schwartz, Lorna Ewart, Michael Bscheider, Lisa Chakrabarti #mRNA, #vaccine, #immunology, #LNP, #immunization, #chips, #lymphoidorganchip