#ThrowbackThursday to when Gut Journal (Gastroenterology at BMJ) released this video abstract of work at the Milner Therapeutics Institute in collaboration with Professor Matthias Zilbauer 😎 Learn how Thomas Dennison and colleagues grew and analysed more than 300 mini-guts – also known as gut organoids – in the lab to investigate changes in the gut epithelium that were found in Crohn’s disease, but not in organoids from healthy donors. 👉 Watch the video: https://lnkd.in/e89HpJHF 👉 Read the paper: https://lnkd.in/eAFpUMfV 👉 Visit the Milner Target Discovery and Functional Validation group, led by Dr Erica Bello: https://lnkd.in/emJFrYVd 👉 Visit the Zilbauer lab, based at the Cambridge Stem Cell Institute: https://lnkd.in/e4HK5m85
Milner Therapeutics Institute’s Post
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Exploring RNAs in tumor-derived extracellular vesicles and their role in the tumor microenvironment: in this review article, Jan Balvan at Masaryk University Brno and collaborators presented an overview of recent studies on tumor-derived extracellular vesicles and their RNA cargo, emphasizing the role of these RNAs in carcinogenesis https://lnkd.in/eU9RDXaA They concluded that tumor-derived extracellular vesicles represent a dynamic and rapidly evolving research area with significant potential to contribute to novel therapeutic approaches and diagnostic strategies. An article also authored by Maria Bugajova, Martina Raudenska, Michal Masarik, David Kalfeřt and Jan Betka #extracellularvesicles #exosomes #RNA #tumourmicroenvironment #cancerresearch #Vesiculab
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Our latest review by Maria Bugajova!
Exploring RNAs in tumor-derived extracellular vesicles and their role in the tumor microenvironment: in this review article, Jan Balvan at Masaryk University Brno and collaborators presented an overview of recent studies on tumor-derived extracellular vesicles and their RNA cargo, emphasizing the role of these RNAs in carcinogenesis https://lnkd.in/eU9RDXaA They concluded that tumor-derived extracellular vesicles represent a dynamic and rapidly evolving research area with significant potential to contribute to novel therapeutic approaches and diagnostic strategies. An article also authored by Maria Bugajova, Martina Raudenska, Michal Masarik, David Kalfeřt and Jan Betka #extracellularvesicles #exosomes #RNA #tumourmicroenvironment #cancerresearch #Vesiculab
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OniX - Connecting Ideas to Opportunities | Biotech Innovation Accelerator | Academic Research to Market | Strategic Partnerships | Funding Strategist
The cGAS-STING intracellular DNA-sensing pathway has emerged as a key element of innate antiviral immunity and a promising therapeutic target. The existence of an innate immune sensor that can be activated by any double-stranded DNA (dsDNA) of any origin raises fundamental questions about how cGAS is regulated and how it responds to “foreign” DNA while maintaining tolerance to ubiquitous self-DNA. In this review, we summarize recent evidence implicating important roles for cGAS in the detection of foreign and self-DNA. We describe two recent and surprising insights into cGAS-STING biology: that cGAS is tightly tethered to the nucleosome and that the cGAMP product of cGAS is an immunotransmitter acting at a distance to control innate immunity. We consider how these advances influence our understanding of the emerging roles of cGAS in the DNA damage response (DDR), senescence, aging, and cancer biology. Finally, we describe emerging approaches to harness cGAS-STING biology for therapeutic benefit. https://lnkd.in/eyJ5c6WZ #cGAS #cGAMP #STING #antiviralimmunity #interferons
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Advisor, Strategist, Advocate/Educator, Networker, Writer, Producer (connecting people to the Ultimate Lifestyle Transformation) #guthealth, #healthyliving, #100%OrganicSuperfoods
Regulatory standards set for safety limits on wireless radiation by our three-letter favs (FDA, FCC): WHACKED! MEANINGLESS! And have nothing to do with keeping humans safe from wireless radiation.
Director of Wireless and Electromagnetic Fields Program, Environmental Health Sciences
New paper by Hakki Gurhan and Frank Barnes "The findings demonstrate that cancer cells exhibit frequency-specific sensitivity to RF fields even at intensities significantly below current safety standards, highlighting the need to reassess exposure limits." Open Access https://lnkd.in/eUcKhyVJ
Frequency-Dependent Antioxidant Responses in HT-1080 Human Fibrosarcoma Cells Exposed to Weak Radio Frequency Fields
mdpi.com
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Partnering to Advance Leukemia Research 🔬 The SeaHawk Group is proud to support the Laboratory of Dr. Katsantoni in the Biomedical Research Foundation of the Academy of Athens (BRFAA), one of Greece’s leading institutions in biomedical science. While BRFAA conducts groundbreaking work across many areas of research, our sponsorship is dedicated to advancing leukemia studies—helping to uncover new insights and solutions for this challenging disease. We’re honored to contribute to the impactful work being done at BRFAA, supporting science that has the potential to change lives and shape a healthier future. #SeaHawkMaritime #BiomedicalResearch #LeukemiaResearch #SupportingScience #BRFAA
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Here's a great tool if you're looking at how proteins interact - with proximity ligation you ONLY get signal where the proteins are co-localized, and within about 40nm - which is hard to determine using a double IF stain due to microscope resolution issues.
Get ready to explore 🧐, it is #productlaunch! 🚀 Navigate immune responses with our latest innovation - the Naveni CD8/MHC-I in situ assay kit. 💥 This kit offers a nuanced perspective on CD8/MHC-I interactions, providing a detailed portrayal of #immuneresponses. This functional understanding of the immune system is pivotal for developing targeted #immunotherapies, representing a potential leap forward in #precisionmedicine for #cancertreatment. Proudly standing as the first commercial in situ proximity ligation assay for the specific detection of CD8/MHC-I interactions, we now expand our targeted-specific portfolio, introducing additional assays to illuminate function in spatial proteomics. Ready to delve deeper? Explore the Naveni CD8/MHC-I product and elevate your comprehension of immune responses: https://lnkd.in/dy2ZnUCh #InSituProximityLigation #ProteinProteinInteractions #SpatialInteractomics #SpatialProteomics #SpatialBiology #Navinci
Product launch: Naveni® CD8/MHC-I kit - Navinci
https://navinci.se
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You won’t want to miss this seminar by DefiniGEN’s Founder and CSO Prof. Ludovic Vallier: "Understanding Human Organogenesis to Develop Therapies Against Liver Diseases." 🗓️ Date: Thursday 12th September ⏰ Time: 14:00 GMT 📍 Location: Petersfield Lecture Theatre, Babraham Research Campus Talk Abstract: Ludovic’s upcoming seminar will feature pioneering research on the molecular mechanisms governing liver development, focusing on the generation of cholangiocytes and hepatocytes—the liver's two main functional cell types. By utilizing human pluripotent stem cells and primary liver organoids, his team investigates the mechanisms driving progression of non-alcoholic fatty liver disease and how these insights can develop new regenerative therapies. Don't miss this opportunity to gain insights into the latest advancements in liver disease research and explore potential therapeutic avenues that could transform patient outcomes. Register for the seminar here: https://lnkd.in/e-Gvy9sE Learn more about how DefiniGEN is developing groundbreaking tools to aid in studying Liver diseases here: https://lnkd.in/eRVXmF4U #BiomedicalResearch #LiverDisease #StemCellResearch #Liver #BabrahamInstitute
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Unraveling the Mysteries of Apoptosis: A Deep Dive into Programmed Cell Death In this blog post, we delve into the intricacies of programmed cell death, exploring its molecular mechanisms and the significance of the BCL-2 family of proteins. https://lnkd.in/e2sCvsvf Join us as we cover the key players of this fundamental cellular process and its impact on human health. Biosynth offers a wide range of high-quality BCL-2 family proteins, including activators, sensitizers, and effectors, essential for apoptosis research. We also provide expert support and custom services to help researchers advance their understanding of programmed cell death and develop innovative therapeutic strategies, from concept to commercialisation. Contact us today. https://lnkd.in/e7cXNb25 #apoptosis #programmedcelldeath #BCL2family #molecularbiology #cellbiology #cancerresearch #therapeutictargets #biomedicalresearch
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Get ready to explore 🧐, it is #productlaunch! 🚀 Navigate immune responses with our latest innovation - the Naveni CD8/MHC-I in situ assay kit. 💥 This kit offers a nuanced perspective on CD8/MHC-I interactions, providing a detailed portrayal of #immuneresponses. This functional understanding of the immune system is pivotal for developing targeted #immunotherapies, representing a potential leap forward in #precisionmedicine for #cancertreatment. Proudly standing as the first commercial in situ proximity ligation assay for the specific detection of CD8/MHC-I interactions, we now expand our targeted-specific portfolio, introducing additional assays to illuminate function in spatial proteomics. Ready to delve deeper? Explore the Naveni CD8/MHC-I product and elevate your comprehension of immune responses: https://lnkd.in/dy2ZnUCh #InSituProximityLigation #ProteinProteinInteractions #SpatialInteractomics #SpatialProteomics #SpatialBiology #Navinci
Product launch: Naveni® CD8/MHC-I kit - Navinci
https://navinci.se
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A new study led by senior author Nobel-Winning Scientist Carol Greider suggests that there are yet undiscovered mechanisms for telomere length regulation, offering hope for developing new approaches to cancer and certain degenerative diseases.🧬👩🔬🔬 The PhD work of first author Kayarash Karimian, the research challenges what is currently known about telomere length patterns while acting as a proof-of-concept study for using scalable Nanopore-based techniques to measure telomeres with nucleotide-level resolution. The paper was published in Science Magazine. Read more here 👇 https://lnkd.in/eJA43xy9 Contributors: ・The Johns Hopkins University School of Medicine ・Oxford Nanopore Technologies ・University of California, Santa Cruz #Telomeres #Genetics #NanoporeSequencing #DNA #HumanGenetics
Excited to share my PhD work out in Science Magazine today. Telomere length profoundly impacts human health. Short telomeres result in diseases like idiopathic pulmonary fibrosis (IPF) while cancers must lengthen telomeres for sustaining continued cell division. Yet, the lack of accurate and easily accessible methods to measure telomere length at scale has prevented its broad use in clinic or drug discovery settings. We developed a scalable Nanopore based method that measures telomeres on all chromosome arms with nucleotide resolution and found some surprising results! Established models for telomere length have predicted that all telomeres are created equal and are uniformly regulated in the same manner. Here we show that this is not the case. Rather, specific chromosome arms in humans had the shortest and longest telomere lengths and the rank order was conserved across nearly 150 different individuals. We also established that humans are born with ~8 kb of telomere sequences while being able to separate out individuals with Idiopathic Pulmonary Fibrosis (the most common manifestation of telomere related disease) from healthy adults based on telomere length, showing the potential utility of Telomere Profiling in clinical settings. This work would not have been possible without the support of so many individuals and collaborators. Special thanks to my mentor Carol Greider and our funders, especially the Bloomberg Distinguished Professorship Fund and The Johns Hopkins University School of Medicine's MBG department without which this work would not have been possible. I hope this small contribution can help expand our understanding of telomere biology and advance new drug discovery efforts for patients in the future. Oxford Nanopore Technologies, National Science Foundation (NSF), National Cancer Institute (NCI) https://lnkd.in/ekB3gvyZ
Human telomere length is chromosome end–specific and conserved across individuals
science.org
