Michal Maj’s Post

Hear from your peers about the flexibility of MauriceFlex for routine protein size, charge quantitation, and charge fractionation for downstream characterization. A true multi-attribute analysis solution that is a must-have in the lab.

🔬 Essential Guide to HBSS in Cell Culture Applications 🌱 At Purma Biologics LLC, we understand the critical role that Hank's Balanced Salt Solution (HBSS) plays in cell culture. HBSS is indispensable for maintaining physiological pH and osmolarity, creating an ideal environment for cell manipulation, washing, and transport. Dive into our comprehensive guide to explore how HBSS can enhance your cell culture processes. . . . #PurmaBiologics #CellCulture #HBSS #Biotechnology #ScientificResearch #CellBiology

Learn more about the benefits of accelerating assay run times with microfluidic assays for oligo therapeutics.

⭐️The excitement is great and preparations are ongoing - the #IOPC2024 will be a very special event. This is why... 🔄The peptide therapeutics landscape is changing dramatically. Not only due to the success of obesity treatments with GLP-1 analogs, but also due to fading boundaries to other modalities like oligonucleotides. The associated challenges for synthesis, in particular, are immense and, in order for us to help overcome them, conferences like IOPC are fundamental to engage with the scientists and understand their needs. 👨🔬 👩🔬 💡We have prepared for this event with a set of new application data and we are happy to share this in advance: https://lnkd.in/dyrPC82T 📍Please meet our team including Luísa Aguiar and Silvia Marini at booth #16 to discuss your project and how PurePep solutions can help you innovate for a better life. #purepep #oligonucleotide #peptides #synthesis #purification

For ion channel researchers there is a great new resource available online and soon to be in print. The Ion Channels as Targets in Drug Discovery book (Springer), within which is our chapter on tools and therapeutics from venoms and toxins. Figure 1 has a handy map and overview of the types of targets with toxin ligands that we know of so far. So if you have an ion channel target and your chemistry is not generating the hits you need, maybe you should try venoms and toxins. read more here - https://lnkd.in/eq4NcMXG

Producing engineered extracellular vesicles for therapeutics applications: in this study, Kristin Luther, Joe Nabhan at Vesigen Therapeutics, Inc. and collaborators evaluated two scalable strategies for generating GFP-loaded ARMM-engineered EVs: transient transfection and stable cell line-based production. The upstream ARMM production processes used a suspension HEK293-derived line called 5B8 from Lonza, with production assessed in both shake flasks and bioreactors. For downstream ARMM purification, they employed Tangential Flow Filtration and Anion Exchange Chromatography https://lnkd.in/eWs8TfSM In vivo, ARMMs demonstrated rapid biodistribution, primarily to the spleen and liver, with lesser distribution to the kidneys and lungs. The successful scale-up of ARMM production highlights the potential of engineered EVs. An article also authored by Ali Navaei, Leah Gens, Carson Semple, Pearl Moharil, Ilaria Passalacqua, Komal Vyas, Qiyu Wang, Shu-Lin Liu, Lucy Sun, Senthil Ramaswamy and Davide Zocco #extracellularvesicles #exosomes #bioengineering #translationalmedicine #cellculture #Vesiculab

I learned so much about ADC at this great workshop by PBSS International.

FIMECS, Inc.'s Principal Scientist, Shigeru Furukubo, Ph.D., will present “Exploring Suitable E3 Ligase Binders for Discovery of Targeted Protein Degraders by Phenotypic-First Approach”, an efficient protein degrader discovery platform, RaPPIDS(TM), at the 19th Annual Drug Discovery Chemistry.   Learn more about the conference here: https://lnkd.in/gkhkep5 FIMECS release hear: https://lnkd.in/gpGCtP9N #FIMECS, #drugdiscovery #proteindegradation

Save the date for the next #MedChemCASES

Cell Dissociation Market worth $1.4 billion by 2028 𝐃𝐨𝐰𝐧𝐥𝐨𝐚𝐝 𝐏𝐃𝐅 𝐁𝐫𝐨𝐜𝐡𝐮𝐫𝐞: https://lnkd.in/dF67mtvX The global #cell #dissociation market in terms of revenue was estimated to be worth $0.6 billion in 2023 and is poised to reach $1.4 billion by 2028, growing at a CAGR of 17.8% from 2023 to 2028. Thermo Fisher Scientific Merck KGaA, Darmstadt, Germany CFE-CGC PALL CYTIVA France Groupe Danaher) Becton, Dickinson and Company Corning Incorporated Inc. STEMCELL Technologies PromoCell Miltenyi Biotec ATCC HiMedia Laboratories Pvt. Ltd. PAN-Biotech GmbH CellSystems® AMSBIO Neuromics VitaCyte Biological Industries Sartorius GeminiBio INNOVATIVE CELL TECHNOLOGIES INC, Central Drug House (P) Ltd. Worthington Biochemical Corporation Capricorn Scientific GmbH Abeomics Inc. Genlantis Diagnostics Inc.