Mohid Mugale’s Post

Reaction kinetics is the study of the rates of chemical reactions, including the factors that influence them. It provides a detailed understanding of how reactions occur and how they can be controlled. Key concepts in reaction kinetics: 1.Rate of reaction: The change in concentration of reactants or products per unit time. 2.Rate constant(k): A measure of the reaction rate, independent of reactant concentrations. 3.Order of reaction: The dependence of the reaction rate on reactant concentrations. 4.Activation energy (Ea): The minimum energy required for a reaction to occur. 5.Catalysts: Substances that speed up reactions without being consumed. 6.Reaction mechanisms: Step-by-step descriptions of how reactions occur. Factors affecting reaction kinetics: 1.Concentration: Increasing reactant concentrations can increase reaction rates. 2.Temperature: Higher temperatures generally increase reaction rates. 3.Pressure: Increasing pressure can increase reaction rates for gaseous reactants. 4.Surface area: Increasing the surface area of reactants can increase reaction rates. 5.Catalysts: Presence of catalysts can significantly increase reaction rates. Types of reaction kinetics: 1. Zero-order kinetics: Rate is independent of reactant concentrations. 2.First-order kinetics: Rate depends on the concentration of one reactant. 3.Second-order kinetics: Rate depends on the concentrations of two reactants. Understanding reaction kinetics is crucial in various fields, including: 1.Chemical engineering: To design and optimize chemical reactors. 2.Pharmaceuticals: To develop and manufacture drugs. 3.Environmental science: To understand and mitigate pollution. 4.Materials science: To develop new materials and processes. Ashish Puranik BE Chemical puranikashish8@gmail.com

#CHEMISTRY: 𝗕𝗿𝗲𝗮𝗸𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗶𝗻 𝗘𝗻𝘇𝘆𝗺𝗲 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗳𝗼𝗿 𝗚𝗿𝗲𝗲𝗻 𝗖𝗵𝗲𝗺𝗶𝘀𝘁𝗿𝘆🔬 Researchers Dr. Xiao-Dan Li, Dr. Richard Kammerer, and Prof. Dr. Volodymyr Korkhov at the PSI Paul Scherrer Institut have successfully characterized the enzyme styrene oxide isomerase for the first time.🚀🔬 Published in Nature Chemistry, this breakthrough paves the way for environmentally friendly production of valuable chemicals and drug precursors. By elucidating the enzyme's structure and function, the team has overcome previous limitations to its practical application.🌱 Using advanced techniques like cryo-electron microscopy, the researchers uncovered that the enzyme's efficiency owes to an iron-containing group, similar to the iron-containing pigment in our blood. This allows the enzyme to split the epoxide ring in styrene oxide, a key step in the Meinwald reaction, with high precision, producing only one specific product.🎯 Their findings promise significant advances for the chemical and pharmaceutical industries, offering a versatile, energy-saving tool for green chemistry.🌐💊 👉 Learn more >> https://lnkd.in/guMZm_jp #BioChemistry #GreenChemistry #EnzymeResearch #SustainableScience #EnvironmentalScience Science-Switzerland Follow the Consulate of Switzerland, Swissnex in Japan🇨🇭🇯🇵 #AddingValue | #Education | #Research | #Innovation | #Startups🚀 | #VitalitySwiss

Cryo-EM data collection and processing All the cryo-EM datasets of SOI were collected using EPU software on a 300-kV Titan Krios system (Thermo Fisher Scientific ) equipped with a Gatan K3 direct electron detector and a Gatan Quantum-LS GIF, at ScopeM, ETH Zurich. All movies were acquired in super-resolution mode with a defocus range of −0.5 to −3 μm and were binned twofold after acquisition in EPU.

Baylor Chemistry & Biochemistry Department Assistant Professor, Dr. Liela (Bayeh) Romero, has developed an innovative approach to selectively reduce esters into valuable aldehydes, offering a cost-effective and scalable solution for chemical and industrial applications. Esters are vital components used across various industries, including food flavorings, perfumes, and polymer production. The selective reduction of esters into aldehydes, rather than alcohols, is a crucial step in producing valuable chemical intermediates. Current methods, such as the use of diisobutylaluminum hydride (DIBAL-H), are costly and require specialized conditions like cryogenic temperatures. This technology, however, offers a breakthrough by enabling ester reduction at 80°C, using a zirconocene catalyst that provides high yields of aldehydes (84%) and intermediate imines/enamines (up to 99%), all while maintaining high selectivity and minimal alcohol formation. This technology can be used for pharmaceutical, agrochemical, flavor and fragrance chemistry, and PET upcycling applications. To learn more about the research behind this innovation, check out this publication: https://lnkd.in/dRedE8EF This technology is currently available for licensing through the Baylor Office of Innovation & Economic Development: https://lnkd.in/gRgcce3y #BaylorMade #TechTuesday Ioniqa Technologies rPET InWaste, sro CircularPET eeden Nouryon Avantium GC Bachem TCI - Tokyo Chemical Industry Oakwood Chemical Pyrowave Ecovyst, Inc. Lianhetech Europe Limited

Surface-Enhanced Raman Spectroscopy Detection for Fenthion Pesticides Based on Gold Molecularly Imprinted Polymer Solid-State Substrates Read the full article here: https://buff.ly/4gekOiw Current label-free surface-enhanced Raman spectroscopy (SERS) assay for the detection and analysis of organophosphorus pesticides has achieved initial success, but the application still faces constraints of substrate portability and specificity. To this end, this paper demonstrates a method for portable, rapid, and specific detection of low concentrations of fenthion pesticides based on a solid substrate of gold nanoparticle monolayers combined with molecularly imprinted polymers (MIPs). The nano-monolayers were transferred to the surface of mercapto-silicon wafers by interfacial self-assembly technique to form a stable connection with S–Au bonds and, at the same time, prevent nanoparticles from dropping off during the surfactant removal process. Then, the fenthion MIPs were directly generated on the surface of the monolayer film by spin-coating with a pre-polymerization solution and ultraviolet-induced polymerization. Tests showed that the molecular imprint was able to accurately bind to fenthion, but not other molecules, in a mixture of structural analogs, achieving a low concentration detection of 10–8 mol/L. The composite substrate maintained a signal uniformity of a relative standard deviation (RSD)  =  7.05% and a batch-to-batch reproducibility of RSD  =  10.40%, making it a potential pathway for the extended application of SERS technology. Sage

🗞 WORKSHOP “The power of evolution: engineering enzymes for biosensing applications" ·       Summary: Uncover the world of enzyme engineering and biosensors! This free workshop will explore the cutting edge of biotechnology. You'll learn how scientists in EvoEnzyme use directed evolution, a powerful technique that mimics natural selection, to create custom-made enzymes. The workshop will also explore how engineered enzymes are harnessed to create highly sensitive biosensors. The workshop is scheduled within the framework of the European Pathfinder Project WOUNDSENS, which focuses on developing innovative biosensors for continuous wound monitoring. By attending, you'll gain insights into this exciting project and its potential impact on healthcare monitoring. Learn about: ·       Fundamentals of enzyme engineering ·       Designing enzymes with directed evolution ·       Yeast as a tool in enzyme engineering ·       Uses of engineered enzymes in biosensors No prior knowledge required. Free workshop with certificate of attendance. 🗓 Date: April 16th, 2024 Registration open until April 11th To register, please send an email with your details to the following address: info@woundsensproject.eu indicating your name and last name, Academic title, Organisation, Position within organization, Motivation (Please describe shortly your motivation to join the workshop). We will contact you as soon as possible and send you the complete schedule and agenda. “Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or European Innovation Council and SMEs Executive Agency (EISMEA). Neither the European Union nor the granting authority can be held responsible for them.”

One of my informative projects at university involved analytical methods. Solvent Extraction: Solvent extraction, also called liquid-liquid extraction (LLE) and partitioning, is a method to separate compounds based on their relative solubilities in two different immiscible liquids.  Ultrasound-assisted extraction (UAE): is a relatively novel method relying on sound waves (20 kHz-100 MHz frequency) that induce cavitation and pressure variations through extracting solvents. This force is transformed into mechanical energy degrading cell walls and improving metabolites recovery into extraction solvents.  Cold pressing of seeds produces high-quality oils mechanically in an environmental-friendly approach free from any chemical contaminants. cold pressing resulted in the production of orange seed oil rich in bioactives (e.g., naringin, gallic, and syringic acids), terpene volatiles (e. g., β-pinene, β-myrcene, α-phellandrene, β-cymene and D-lemonene) compared to the hexane-extracted counterpart. 

Researchers at the Technion-Israel Institute of Technology have unveiled a revolutionary chemical process called triazenolysis, which could significantly impact medicine, agriculture, and beyond. This method transforms alkenes, commonly found in petroleum-derived compounds, into multifunctional amines. These amines hold incredible promise for advancing polymers, pharmaceuticals, and agricultural products, offering new possibilities in industrial and scientific fields. Unlike the century-old ozonolysis process, which forms carbon-oxygen bonds, triazenolysis creates vital carbon-nitrogen bonds, unlocking broader applications. The research, led by Prof. Mark Gandelman and his team, including doctoral students Alexander Koronatov and Deepak Ranolia and postdoctoral researcher Pavel Sakharov, provides a deeper understanding of this innovative process. Published in Nature Chemistry, the study demonstrates how triazenolysis works by cleaving carbon-carbon bonds in olefins, creating valuable carbon-nitrogen bonds with high efficiency. This breakthrough, backed by computational analysis to refine its mechanisms, paves the way for advancements in creating raw materials essential to modern industries. It represents a leap forward in the field of chemistry, promising to drive innovations in diverse areas from sustainable agriculture to cutting-edge drug development. Original author: Alex Koronatov, Deepak Ranolia, Pavel Sakharov, and Mark Gandelman. Great News Summary made with help from ChatGPT. https://lnkd.in/guc2nb9i

Here are the main points from the article: Triazenolysis: A new chemical process called triazenolysis has been introduced, which transforms alkenes into multifunctional amines. These amines have potential applications in polymers, pharmaceuticals, and agriculture. Comparison with Ozonolysis: Unlike the century-old ozonolysis that forms carbon-oxygen bonds, triazenolysis efficiently creates carbon-nitrogen bonds, making it more versatile for various scientific and industrial fields. Research Team: The process was developed by researchers at the Schulich Faculty of Chemistry at the Technion, including doctoral students Alexander Koronatov and Deepak Ranolia, postdoctoral researcher Pavel Sakharov, and Prof. Mark Gandelman. Publication: The study was published in Nature Chemistry and supported by the Israel Science Foundation. This breakthrough could significantly impact the production of raw materials for various industries. Fascinating, isn't it? https://lnkd.in/g9KFY-H6

B: Soft Matter, Fluid Interfaces, Colloids, Polymers, and Glassy MaterialsDecember 29, 2024 Active Site Studies to Explain Kinetics of Lipases in Organic Solvents Using Molecular Dynamics Simulations Helena D. TjørnelundJesper BraskJohn M. WoodleyGünther H. J. Peters* The Journal of Physical Chemistry This study investigates the intricate dynamics underlying lipase performance in organic solvents using comprehensive molecular dynamics (MD) simulations, supported by enzyme kinetics data. The study reveals that a single criterion can neither predict nor explain lipase activity in organic solvents, indicating the need for a comprehensive approach. Three lipases were included in this study: Candida antarctica lipase B (CALB), Rhizomucor miehei lipase (RML), and Thermomyces lanuginosus lipase (TLL). The lipases were investigated in acetonitrile, methyl tert-butyl ether, and hexane with increasing water activity. Computational investigations reveal that CALB’s activity is negatively correlated to water cluster formations on its surface. In contrast, TLL’s and RML’s activity profiles show no negative effects of high water activity. However, TLL’s and RML’s activities are highly correlated to the conformation and stability of their active site regions. This study may pave the way for tailored applications of lipases, highlighting some of the factors that should be considered when lipase-catalyzed reactions are designed. This publication is licensed under CC-BY-NC-ND 4.0 . cc licence by licence nc licence nd licence © 2024 The Authors. Published by American Chemical Society Subjects