Ncardia’s Post

Gratitude to ASTRO and IJROBP for featuring our recent paper on their website “Outtakes” sectjon. It’s a privilege to have the opportunity to explain our research on gene expression profiling in cutaneous squamous cell carcinoma and how the @decisiondxscc test can help identify patients that will benefit from adjuvant radiation. As a Mohs surgeon, knowing which patients to refer to my colleagues in radiation oncology is incredibly important. We know what clinical and pathological features are high risk- knowing the biological predictors of risk is a major addition to our prognostic abilities. https://lnkd.in/gFfpSi6M

Highly recommend this deep dive series on major translational themes at this year's American Society of Gene & Cell Therapy meeting from my BioCentury Inc. colleagues Lauren Martz and Danielle Golovin, Ph.D. : CAR Ts outside of cancer (and even outside autoimmunity!), epigenetic editor durability, vectorized mAbs, blood-brain barrier crossing technologies, and more. https://lnkd.in/gmaFDith

#cancerresearch #oncology #braintumor https://lnkd.in/dG5PBFhh Serotonin affects brain-tumour growth The #neurotransmitter #serotonin can influence the gene expression of brain-tumour cells by travelling into the nucleus and modifying proteins called histones. Inhibiting this process stopped an aggressive type of paediatric #brain #tumour called ependymoma from developing in mice. “This study identifies histone serotonylation as a key driver of ependymoma tumorigenesis,” report the authors.

"Excited to share a glimpse of my dissertation work, focusing on the MYC gene rearrangement in diffuse large B-cell lymphoma (DLBCL) patients using the FISH method. My research delves into understanding the molecular mechanisms underlying DLBCL, shedding light on the role of myc rearrangement in disease progression and potential therapeutic implications. Through rigorous analysis and innovative methodologies, I aim to contribute to the growing body of knowledge in the field, ultimately advancing our ability to diagnose and treat DLBCL more effectively." "Embarking on a journey of scientific discovery, my dissertation investigates the prognostic implications of myc rearrangement in diffuse large B-cell lymphoma patients, employing the FISH methodology to decipher its impact on patient outcomes and treatment strategies."

There is still time to register for our upcoming webinar: "Development of #digitalPCR-based products to test for cancer-related gene mutations in cancer tissue and liquid biopsies." Sign up to learn more about how IDT is playing a critical role in transforming cancer mutation research: https://bit.ly/4eUw2YA

Speed matters in cancer research, and the nCounter workflow delivers results in less than 24 hours with less than 15 minutes of hands-on time. Imagine how much faster answers could impact YOUR studies. Accelerate your insights today with direct digital detection gene expression analysis. https://bit.ly/3GwrQOZ #geneexpressionanalysis #cancerresearch #oncology

#HighlyCitedPapers 📝 Gene Expression Profiling in Early Breast Cancer—Patient Stratification Based on Molecular and Tumor Microenvironment Features — Munkácsy et al. In this paper, the authors aimed to evaluate the current evidence of using #gene expression signatures or profiling (GEP) in clinic and explore and discuss the increasing importance of immune parameters and the possibility to refine current tools with additional immune-GEPs that may help to refine prognosis and provide better predictive tools for early-stage breast #cancer. Full text is available 👇 https://lnkd.in/dxvmVf2x #medicine #health #research #science

Precision oncology has made significant strides in matching cancer patients to targeted treatments through genetic testing. However, a new approach using RNA analysis alongside DNA is being explored to better predict treatment responses. 🧬 The AI-driven tool PERCEPTION is fine-tuning predictions by analyzing single-cell gene expression data, offering a clearer picture of how cancer will respond to treatment. Read the article here: https://ow.ly/tejo50SxqZj The National Institutes of Health #oncology #cancerresearch #AI #DNA #RNA #genetictesting #research #precisiononcology

Meet FAST entrepreneur 🚀 Matthew Lorence, Ph.D., MBA is the CEO & Founder of CDR3 Therapeutics, Inc. CDR3 is developing a blood stem cell-based therapy to treat HPV-associated cancers, which overcomes the limited persistence of current peripheral blood T cells harvested from the patient, by performing gene therapy on patient stem cells that engraft in the patient’s bone marrow, leading to persistent development of fully functional T cells targeting the cancer. Learn about #FASTCA: https://bit.ly/3QfMLuW

🔬 Understanding DNA Methylation in Cancer: An Essential Insight! 🧬🔎 Explore the crucial role of DNA methylation in cancer development and progression. 🦠✨ 📚 Gain valuable knowledge about epigenetic control and its impact on gene expression. 🔬 Learn about liquid biopsies, biomarkers, and the potential of cell-free DNA in cancer research. 🌟 Stay updated with the latest advancements in diagnostic, prognostic, and treatment response monitoring. Read more: https://lnkd.in/gbET2qPP #DNAMethylation #CancerResearch #LiquidBiopsies #Biomarkers #Epigenetics #Science #Healthcare