Oncodesign Services’ Post

Reviewing the therapeutic applications of engineered exosomes: in this article, Verena Poinsot, Nathalie Pizzinat and Varravaddheay ONG-MEANG at Université de Toulouse emphasised the use of alternative exosome-mimics, including cell-membrane-coated artificial nanocarriers and hybrid structures combining exosomes with liposomes https://lnkd.in/ehreGk6z They discussed the strategies for loading drugs onto these carriers and provide an overview of current clinical trials involving exosomes or exosome-like structures, and outlined remaining questions before considering exosome-like systems for effective therapeutic delivery #exosomes #extracellularvesicles #drugdelivery #nanomedicine #Vesiculab

Dive into our latest blog where we dissect the diverse response criteria based on imaging endpoints. We’re comparing their pros and cons and exploring how they can be improved. Focusing on structural imaging like CT and MRI versus functional imaging in PET scans, we explore how each method may impact the evaluation of new medical treatments. Click here to read: https://lnkd.in/ggQi_reM #ImaginAb #immunooncology #CD8ImmunoPET #biotech #pharma #theranostics #PETCT #nuclearmedicine #clinicaltrials Matthew Hoover

We started a longitudinal study to assess imaging biomarkers in relation to new bone formation and inflammatory characteristics in patients with axial spondyloarthritis and psoriatic arthritis together with COPECARE and the department of radiology of Herlev og Gentofte Hospital. Earlier studies (Refs: Willesen ST, et al. Ann Rheum Dis 2024; Jans LBO, et al. Radiology 2022) demonstrated the ability of #BoneMRI to detect structural changes in these populations, however this study investigates the effect of treatment with a pharmaceutical compound and the ability to detect structural bone changes in an early phase. Paper: https://lnkd.in/e9FkQxJs Willesen ST, et al. Ann Rheum Dis 2024. Simone Tromborg Willesen Mikkel Østergaard Rigshospitalet #BoneMRI #Spondyloarthritis #EarlyDetection #MRI

💉🩺Why do pre-filled syringes sometimes play hide-and-seek with meds? Researchers Vladimir Novak, David Mannes, and Margie O. from the Paul Scherrer Institut PSI, along with Dr. Christian Grünzweig from the ANAXAM - Technology transfer center for advanced manufacturing, collaborated with MSD to investigate the causes of clogging in prefilled #syringes (PFS). PFS are increasingly used for cancer treatment, for example, using monoclonal antibodies. Utilizing advanced neutron and synchrotron imaging techniques at PSI's #SwissLightSource #SLS and #SINQ neutron source – an ensemble that is unique in the 🌎 – the scientists discovered that fluctuations in pressure and temperature during transportation and storage lead to needle blockages due to deposits forming on the needle's metal surface and the formation of air bubbles. 🌡️Novak emphasized the significance of their findings, stating, 'The combination of neutron imaging and synchrotron X-ray tomography clearly demonstrates' the importance of maintaining an uninterrupted cold chain and stable pressure conditions when transporting and storing PFSs. This discovery offers valuable insights for #pharmaceutical manufacturers, distributors, and #healthcare providers. #ResearchAtPSI #Health #Neutrons #LightSourceScience #SynchrotronScience #ScienceForSociety Lightsources.org

READ OF THE DAY: Grow organoids or spheroids that mimic the function, structure, and architecture of in vivo cells (Written By Brandy Sargent) https://lnkd.in/e6D9skd9 #Cellculture #celltherapy #lifescience #research #genetherapy #pharma #biotech CelVivo

Ophthopedia Update:Fluid Pathways in Age-Related Macular Degeneration Elucidated with Advanced Retinal Imaging: Subretinal (SRF) and intraretinal fluid (IRF) are tried and true biomarkers of neovascular activity in age-related macular degeneration (AMD) indicating the need for intravitreal anti-VEGF therapy. But it is becoming abundantly clear that the exudative pathways in AMD are much more complex. Although neovascular fluid is certainly a common complication of AMD, other mechanisms should be considered including degenerative and tractional etiologies.1 #Ophthalmology #Retina #Ophthotwitter

🌟 Unlock the Power of Advanced Cryopreservation with Entegris Aramus Film! 🌟 In the cell therapy industry, ensuring the stability, purity, and viability of cellular materials is paramount. That’s why Entegris developed Aramus™ single-use film, engineered specifically to meet the unique challenges of cell therapy. Here’s how Aramus film makes a difference: 🔹 **Chemical Compatibility with DMSO** – Aramus film is highly compatible with DMSO, a critical component in cryopreservation. This compatibility ensures stable storage and transport of your cellular products. 🔹 **Low-Temperature Performance** – Designed to withstand ultra-low temperatures, Aramus film provides the durability and flexibility needed to protect your valuable biological materials, even in extreme cryogenic conditions. 🔹 **Particle-Free Manufacturing** – Our particle-free manufacturing process helps safeguard the purity of your materials, keeping them clean and safe for cell therapy applications. Discover how Aramus can enhance your processes and help deliver safe, effective therapies to patients. Learn more about our solutions or connect with us today to discuss your unique needs! #Entegris #AramusFilm #CellTherapy #Cryopreservation #DMSO #Biopharma #SingleUseSolutions

Preclinical Imaging Market Worth $5,101 Million Request Free Sample Report: https://lnkd.in/dSTKe_ej Preclinical Imaging Market by Product Type (Optical Imaging (Bioluminescance), PET, SPECT, MRI, Optical Imaging Reagents (Infrared Dyes), Software), Application (Oncology, Neurology), End User (Pharma, Imaging Centers) & Region - Global Forecast to 2029 𝐓𝐡𝐞 𝐜𝐨𝐦𝐩𝐚𝐧𝐢𝐞𝐬 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐢𝐧 𝐭𝐡𝐢𝐬 𝐫𝐞𝐩𝐨𝐫𝐭 𝐢𝐧𝐜𝐥𝐮𝐝𝐞: MR SOLUTIONS, Mediso Ltd. (UK), Sofie (US), FUJIFILM VisualSonics, Inc., MILABS B.V. (Netherlands), Aspect Imaging, Li-Cor Biosciences (US), ICONEUS (Paris), Advanced Molecular Vision (UK), Viewworks (Korea), Kub Technologies (US), Medikor (US), Trifoil Imaging (US), IVIM Technology, Cubresa, Inc. (Canada), Berthold Technologies GMBH & CO.KG (Germany), Miltenyi Biotech GmbH (Germany), AI4R (France), Bruker, and Revvity Other Companies that are Operating in this Market Globally: Aspect Imaging Veranex FUJIFILM VisualSonics, Inc. Xstrahl ONWARD Medical corpuls | GS Elektromedizinische Geräte G. Stemple GmbH 1MED SA CÚRAM, SFI Research Centre for Medical Devices    T3 Labs - Translational Testing and Training Laboratories, Inc. Aliri Bioanalysis Biologics Consulting Bolt Biotherapeutics, Inc. Ascidian Therapeutics Kemwell Biopharma Avellino GENFIT Oryzon Genomics SA PYC Therapeutics (ASX: PYC) StageBio Agilex Biolabs Pty Ltd Gero ERBC GROUP ITR Laboratories Canada Inc. Bioserve - A REPROCELL Company Hesperos Inc. GenomeScan Development Center for Biotechnology #PreclinicalImaging #MolecularImaging #BiomedicalResearch #ImagingTechnology #DrugDevelopment

Through dedicated innovation and development, alpha radiopharmaceuticals and new solid-state detector SPECT systems empower nuclear medicine to remain at the forefront of oncology treatment. Very interesting and educative video below - thanks to the efforts of the scientists and educators in this field! 👏 #nuclearmedicine #molecularimaging #alphatherapy #Spectct

Invited Lecture by Dr. Yong Du; Associate Professor of Radiology, Johns Hopkins Medicine: "SPECT Imaging for Alpha Radiopharmaceutical Therapy" https://lnkd.in/efqEf42Z Chapter Breakdown: 0:00 Introduction 1:15 #Radiopharmaceutical Therapy (#RPT) 3:40 Beta and alpha RPTs 7:28 Rationale for #dosimetry in RPT 9:30 RPT treatment planning flowchart 14:15 Quantitative SPECT activity estimation 15:03 SPECT vs. PET 20:00 Challenges with #SPECT imaging of alpha-emitters 26:42 Solutions for imaging alpha emitters 34:30 Animal studies of Ac-225 35:23 Patient SPECT/CT imaging (Fr-221 and Bi-213) 36:02 New alpha SPECT systems 46:47 Conclusions