PhD in Chemistry - UNIMI’s Post

Check out our recent paper: “Generation of multimillion chemical space based on the parallel Groebke–Blackburn–Bienaymé reaction”, co-authored by Evgen Govor, Vasyl Naumchyk, Ihor Nestorak, Dmytro Radchenko, Dmytro Dudenko, Yurii Moroz, and Oleksandr Grygorenko. This study evaluated the parallel Groebke–Blackburn–Bienaymé reaction, highlighting Sc(OTf)3 as the superior catalyst. A model 790-member library was obtained with 85% synthesis success rate, generating a 271-Mln. readily accessible (REAL) heterocyclic chemical space mostly containing unique chemotypes, with 432 compounds showing biological activity according to the ChEMBL database. Read more: https://lnkd.in/dqJgQHiK Browse and purchase our products at EnamineStore: https://lnkd.in/diy7GrH5

Exciting new findings in groundwater purification! Researchers from the Korea Institute of Science and Technology (KIST) have recently discovered that nitrate can enrich the natural purification of groundwater, increasing the removal of organic contaminants. Read more about their ground-breaking findings via Phys.org here:

🦠Did you know that some #bacteria could be a new ally in the fight against #PFAS (Perfluoroalkyl and polyfluoroalkyl substances), often cited as "forever chemicals"? Knowing that PFAS are quite recent (at bacteria evolution scale), the challenge to find efficient candidates able to digest PFAS is quite high! 👨🔬Scientists from the University of California identified four strains of bacteria that produced an #enzyme able to digest caffeate, a natural compound with a structure close to some PFAS. 🔬They tested these strains against some PFASs and it was conclusive! Within a few weeks, the targeted PFAS molecules were broken down in smaller fragments that could be disposed of with traditional chemical methods. 🎢The next step is engineering the bacteria to be more efficient and to give them the ability to digest more types of PFASs. The team is optimistic but lucid, degrading every PFAS with a single technique is impossible because of the range of chemical structures in these compounds. To read the full article 👇 https://lnkd.in/eX_xzmBP

The versatile reactivity of diaminoacetylenes allowed the preparation of 2,3-diaminocyclopentadienones by the cycloaddition with diarylcyclopropenones. We used this new pro-chiral ligand class to prepare iron carbonyl complexes for the application in reductive amination catalysis. I'm proud to have finally published the results in Catalysis Science & Technology! https://lnkd.in/eq_DZSDV

NEW PAPER UPDATE: Very happy to share the publication of our next article on mechanochemistry. Due to not only the sustainability benefits but also the reactivity differences sometimes seen with mechanochemistry, we wanted to break into this area and investigate what kind of reactivity was possible. Interestingly, the merger of hypervalent iodine with mechanochemistry is still quite under-explored. Thus, we decided to use this opportunity to investigate if indeed one can transfer solution-phase reactivity over to mechanochemistry, and if there were any reactivity/selectivity differences. In the end, we found we were able to conduct arylations and vinylation reactions with several different types of nucleophiles, as well as the first catalytic transformation involving hypervalent iodine under mechanochemical conditions. This marks a break-through achievement for us as the lessons we have learnt from this project, have been and are being, applied to other projects in the group and will hopefully be communicated soon. Huge thanks to Miguel de Vries Ibañez, whom conducted his masters thesis in our group working with me and completed all the tosyloxylation work, and of course to our P.I. Berit Olofsson! Check out the paper here: https://lnkd.in/dZnnAr-D

Article: Study on reaction mechanism of bioleaching of Nickel and Cobalt from lateritic chromite overburdens, International Biodeterioration and Biodegradation, 65,7- 1041-1048

My Paper Round Up for 2024!!! Bute et al. 2024 Microbial community and extracellular polymeric substance dynamics in arid–zone temporary pan ecosystems Science of the Total Environment https://lnkd.in/dUHhGh6N

Did you know that marine dissolved organic matter contains as much carbon as the Earth’s atmosphere? Understanding its molecular composition at structural resolution can reveal key processes behind global carbon cycling and anthropogenic impacts on our oceans. Using 2D-LC-MS/MS in combination with molecular networking and in silico spectrum annotation, we took the perhaps deepest dive so far into the chemical composition of marine DOM. If that sounds exciting, you can find our new paper in ES&T: https://lnkd.in/ejhDcbYc And blog post here: https://lnkd.in/emZFKx3X

I´m glad to share that our research group has described an enantioselective methodology for the preparation of two different families of fluorinated azatricycles: chromene[4,3-b]pyrrolidines and pyrrolo[3,2-c]quinolines, via 1,3-dipolar cycloaddition of azomethine ylides: