Timeless Biotech’s Post

Excited to share our latest research recently published in Hormones and Behavior! In this study, titled "Oral administration of ethinyl estradiol and the brain-selective estrogen prodrug DHED in a female common marmoset model of menopause: Effects on cognition, thermoregulation, and sleep," our team explored how hormonal interventions impact critical aspects of health during menopause. Using a female common marmoset model, we examined how different forms of estrogen therapy affect: 🛌 Sleep – One of the most affected and often underappreciated aspects of menopause. 🔬 Cognition – How memory and learning are supported during hormonal changes. 🌡️ Thermoregulation – The biological mechanisms tied to hot flashes and body temperature control. Our findings not only deepen our understanding of estrogen’s role in brain health and aging but also provide insights into more targeted approaches for addressing menopausal symptoms. This work reflects the incredible effort and collaboration across disciplines, and I’m deeply grateful to my co-authors and colleagues for making it possible. I hope these findings inspire more conversation around women’s health and aging research! PMID: 39721460 DOI: 10.1016/j.yhbeh.2024.105670

Looking forward to catching up with friends & colleagues and sharing the latest findings from the Brain Health at Midlife & Menopause (BHAMM) study at the MDRS 2024 meeting in Manchester, England! I will share new research findings from my lab that show the transition from pre to post-menopause in middle-aged females with ovaries acts as a “switch” for accelerated aging & memory decline in some postmenopausal females (not all). Memory declines at post-menopause are greater in females with poorer cardiovascular health. Importantly, these memory effects are associated with altered brain activity in medial temporal cortex - an area vulnerable to both ageing & dementia. #womensbrainhealth #brainheart #BHAMMstudy Research – Toronto Metropolitan University

We're halfway through our series with #DrDismissive, who has a "suggestion" for me for my brain fog concerns. Go ahead and watch. Again while the video is meant to be a satire, brain fog is no joke. Turns out that your brain goes through A LOT when you're in the #womenover40. But in many cases, we're told that "it's in our head" and that there is no science to back it up. Well as it turns out, science does back this up and we need more research to get into this a bit more. In this past week, Lisa Mosconi, who is an Associate Professor of neuroscience in neurology and radiology, and director of the Women’s Brain Initiative at Weill Cornell Medicine, completed a study on menopause and brain health in Scientific Reports. It sheds new light on how menopause affects the brain. The research, conducted with 54 healthy women aged 40-65, used advanced brain imaging techniques to explore changes in estrogen activity during menopause. Key Findings: 1. Estrogen Receptor Changes: As women go through menopause, their brains produce more estrogen receptors. This seems to be a way for the brain to compensate for the lower levels of estrogen, a hormone that plays a vital role in many brain functions. 2. Link to Symptoms: The study found that higher levels of these receptors were associated with common menopausal symptoms like memory problems, mood swings, and anxiety. This suggests that these brain changes might be behind some of the cognitive and emotional challenges women face during menopause. 3. Implications for Therapy: Traditionally, it was believed that hormone therapy for menopause had to start early to be effective. However, this study indicates that the brain continues to need estrogen even years after menopause begins. This could mean that hormone therapy might still be beneficial later on than previously thought. 4. Brain Adaptability: Despite the changes brought on by menopause, the brain shows a remarkable ability to adapt. For instance, increases in blood flow to certain areas help keep the brain functioning well even as it undergoes these hormonal shifts. Just remember, #itsnotinyourhead. #justgolong

31 Day Breast Health Challenge Day 30: Deep Breathing Deep breathing techniques can improve lymphatic function and reduce stress. Deliberately copying a relaxed breathing pattern seems to calm the nervous system that controls the body's involuntary functions. Controlled breathing can cause physiological changes that include: lowered blood pressure and heart rate. reduced levels of stress hormones in the blood. Grab the Breast Health Map Journel Today https://lnkd.in/dCRNX32i October is just about over, and it’s time to take charge of your breast health review my 31-Day Breast Health Challenge! Over these last 29 days, you received simple, holistic tips and practices to improve your breast health naturally. From daily self-care routines to hormone-balancing foods and detox strategies, this challenge will leave you feeling empowered and more in tune with your body. 🌸 But that’s just the beginning!

🌟 Did you know that TMC has a YouTube channel where we share a wealth of knowledge on hormone health? Our Clinical Lead Director, Dr Joanne Hobson, speaks with leading specialists in their field. This year, we’ve had the privilege to feature: 🎥 Vikram Sinai Talaulikar discussing menopause after cancer 🎥 Liz Tatham discussing mental health 🎥 @Samuel Hobson discussing Musculoskeletal pain 🎥 @Carrie Martin discussing pelvic floor health 🎥 @Dr Joanne Ritchie discussing endometriosis 🎥 @Dr Ruchika Dhar discussing dermatology ...and many more experts to come! If there are any specific topics you’d like us to cover, or if you’re a specialist in a related field and would like to join one of our talks, please drop a comment below, and we’ll be in touch. 👇 Don’t forget to click the link and subscribe to stay updated with all the latest, evidence-based discussions on hormone health from TMC and our panel of experts. 👉 https://lnkd.in/eWzSQ6Y4 #HormoneHealth #YouTubeChannel #ExpertTalks #Healthcare #TMC #DrJoanneHobson #Menopause #MentalHealth #MusculoskeletalPain #PelvicFloorHealth #SubscribeNow

🔬Exciting breakthrough for #womenshealth: While we knew that hormones and menopause wield significant influence over women's brains, recent post-menopausal brain scans provide tangible proof! 🧠 Examining these scans unveil alterations in brain metabolism and grey matter, associated with expected changes in memory and concentration. For many women, these changes appear to be a temporary adjustment before returning to a new baseline. ❔Based on these findings, a question our ZRT docs are interested in learning: Is this why estrogen supplementation at this time shows a decrease in dementia that we don’t see if people start hormones after the menopause transition? Read the full Washington Post article here: https://wapo.st/3UQONEL

The Washington Post recently published an illuminating article shedding light on the fascinating changes that occur in the brain during menopause. According to the piece, menopause can bring about a range of cognitive shifts that deserve understanding and support. Here are some key takeaways: 1️⃣ Hormonal Flux: As estrogen levels fluctuate, it impacts various cognitive functions. "The ovaries pump out less estrogen, and that can affect brain function," says Dr. Lisa Mosconi, director of the Women's Brain Initiative at Weill Cornell Medical College. 2️⃣ Memory and Focus: The article highlights how memory and focus might be affected during menopause. "It's not that you’re going to forget where you parked the car, but it’s definitely going to take you longer to find it," explains Dr. Pauline Maki, a professor of psychology and psychiatry at the University of Illinois at Chicago. 3️⃣ Sleep Disruption: Sleep disturbances are common during menopause and can exacerbate cognitive changes. "Estrogen withdrawal can lead to symptoms of insomnia and sleep disruption, which can further affect memory and cognitive function," notes Dr. Mosconi. 4️⃣ Brain Health Awareness: Understanding these changes is crucial for supporting women's brain health during menopause. Dr. Mosconi emphasizes the need for tailored approaches, stating, "Women’s health and brain health need to be better understood, and we need more research in this area." Read the full article here: hhttps://lnkd.in/gYgWvduW #Menopause #BrainHealth #WomenEmpowerment #HealthAwareness #MenopauseBrain #CognitiveHealth

🧠 Understanding Menopause Brain: Scientists are unraveling the mystery behind menopause-related cognitive changes. Discover why estrogen levels affect brain health and what it means for cognitive decline and Alzheimer's risk in women. 🔍 Dive into the study findings and explore the impact on women's health: https://bit.ly/3Ll2yWr #MenopauseAwareness #BrainHealth #CognitiveDecline #SeniorCare #CaregivingTips

Real talk happening here with a bit of vulnerability... Have you recently thought, "jeez, WTAF is going on with my memory? Do I have early-stage dementia or something?" Well I definitely have felt this while going through menopause. It's definitely been shocking and a bit scary at times to think that this could be "a thing". And this is exactly the kind of stress that can contribute to #burnout - thinking something is "wrong" with you and it's your fault. Fortunately I have been able to chat with my doctor about this, but I know not everyone has an empathetic healthcare provider. Lots of women have a provider similar to #DrDismissive. The study referenced below by Go Long can be a game changer in #womenshealth but more funds need to be dedicated here both privately and publicly. Here are some key takeaways from the study: - Menopause and Brain Health: The brain actively tries to adapt to the drop in estrogen during menopause, which helps explain some of the symptoms women experience. - Potential for Hormone Therapy: There might be more flexibility in timing hormone treatments to help alleviate menopausal symptoms and support brain health. - Understanding Symptoms: Recognize that symptoms like brain fog and mood changes have a biological basis. Seek help from your doctor and if you don't know the questions to ask your doctor, ask me. Just remember, #itsnotinyourhead. #justgolong

This article was written by Dr Bruce Dorr and published a few days ago. The main focus of this article was testosterone’s effects beyond libido. It also cites Dr Rebecca Glaser’s pioneering work on testosterone implants helping with menopause symptoms after breast cancer-with no apparent increase in occurrence. “Testosterone is the most abundantly produced hormone in women, surpassing estrogen levels by three to four times . Summerized concisely in a 2019 study, both estrogen and testosterone play key roles in the development and function of the reproductive organs, bones, heart, brain, and liver. Production in women begins to decline during reproductive years, and the majority of hormone replacement therapy does not address this reduction of testosterone in post-menopausal women. The addition of testosterone therapy to hormone replacement therapy may improve urogenital, psychological, and somatic symptoms, may improve bone density, and may enhance cognitive performance. Additionally, many patients report improvements in their mood, concentration, motivation, and energy levels.” I’ve been taking testosterone now for nearly 3 years, and I have yet to experience any negative side effects. The positive effects, however, have been a complete clearing of brain fog, regaining back my personality, reduction of muscular aches and pains, increased energy, and reduction of anxiety. If you would like to know more and how I can personally help you with this stage of life, please get in contact. @menopausefact.notficiton #menopausefact.notfiction #trt #hrt #menopause #menopauseeducation #menopausesupport