Medicine

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https://lnkd.in/g9xSbD7m Published article: Peritoneal Carcinomatosis from Ovarian Cancer: A Case Report Author: Andrea González De Godos Summary: Epithelial ovarian cancer is one of the most common causes of cancer-related death in women. More than half of patients are diagnosed at an advanced stage, usually due to the locoregional spread of peritoneal carcinomatosis. We present the case of a 49-year-old woman who suffered from constitutional syndrome and abdominal distention. The imaging tests revealed two large, vascularized, and heterogeneous masses that depended on both ovaries. Bilateral adnexectomy was performed and the result of the anatomopathological study was endometrioid carcinoma moderately differentiated. The patient was treated according to the latest recommendations of the NCCN guidelines. A combination of systemic chemotherapy and cytoreductive surgery has been the standard treatment since the mid-1990s. However, a combination of hyperthermic intravenous and intraperitoneal chemotherapy may reduce plasma toxicity and increase therapeutic effectiveness. #Ovariancancer #Peritonealsurfacemalignancies #Cytoreduction #HIPEC #Postoperativeintraperitonealchemotherapy #AcuteMedicine #AdolescentMedicine #Anatomy #Anesthesiology #Cardiology #ClinicalMedicine #DentalSciences #Dermatology #DrugandMedicalDevices #EmergencyMedicine #EnvironmentalHealth #FamilyMedicine #ForensicMedicine #Gastroenterology #GeneralMedicine #Genetics #Geriatrics #Gynecology #Haematology #HealthEconomics #HealthInformatics #HealthPolicy #HospitalMedicine #Immunology #InternalMedicine #MedicalEducation #MedicalEmergency #MedicalResearch #MolecularMedicine #Neurology #NuclearMedicine #ObstetricsOncology #OccupationalMedicine #Ophthalmology #Orthopaedics #Otolaryngology #Paediatrics #PainManagement #Pathology #Pharmacology #Physiology #PlasticSurgery #Psychiatry #PulmonaryMedicine #Pulmonology #Radiology #RehabilitationMedicine #Rheumatology #Urology #VeterinaryScience

https://lnkd.in/gryE6SCf Published article: Threat to Human and Animal Health Caused by Mycotoxins and Masked Mycotoxins Occurring in Food and Feed Author: Wiesław Barabasz Summary: Fungi, and especially mold fungi, play a very important role in natural environments, as well as in the food industry for the production of many specialized products. However, many of them, under favorable conditions, are capable of producing toxic compounds called mycotoxins. Many of them have an adverse effect on the growth and development of all groups of organisms, including humans. Mycotoxins can appear in all food products and animal feed. Mycotoxins accumulated in food of plant and animal origin and consumed by humans can accumulate in various tissues and organs, which results in disorders in their functioning and may cause cancer. Plants have the ability to defend themselves against mycotoxins by neutralizing them as a result of the glycosidation process. Mycotoxins neutralized in this way are called “masked mycotoxins”, which are not toxic to plants, but after entering the body of animals or humans in the digestive tract, they return back to their original toxic form. Let’s appeal and spread knowledge about mycotoxins because they pose a constant threat to the health of people and farm animals. #Occurrenceofmycotoxins #Toxicity #Maskedmycotoxins #AcuteMedicine #AdolescentMedicine #Anatomy #Anesthesiology #Cardiology #ClinicalMedicine #DentalSciences #Dermatology #DrugandMedicalDevices #EmergencyMedicine #EnvironmentalHealth #FamilyMedicine #ForensicMedicine #Gastroenterology #GeneralMedicine #Genetics #Geriatrics #Gynecology #Haematology #HealthEconomics #HealthInformatics #HealthPolicy #HospitalMedicine #Immunology #InternalMedicine #MedicalEducation #MedicalEmergency #MedicalResearch #MolecularMedicine #Neurology #NuclearMedicine #ObstetricsOncology #OccupationalMedicine #Ophthalmology #Orthopaedics #Otolaryngology #Paediatrics #PainManagement #Pathology #Pharmacology #Physiology #PlasticSurgery #Psychiatry #PulmonaryMedicine #Pulmonology #Radiology #RehabilitationMedicine #Rheumatology #Urology #VeterinaryScience

https://lnkd.in/gy-_yjKS Published article: Preventing Rectal Toxicity in Prostate Cancer: Diet and Supplement Alternative to Enemas or Rectal Spacer Author: Fabrizio Piro Abstract: Background: Rectal toxicity is an important side effect of prostate cancer irradiation affecting 25% of patients. The role of dosimetric variables has a set of dose-volume constraints and curves to estimate the risk of rectal damage. The rectum position at the time of CT planning is different from the position during radiotherapy. Three methods are available to achieve optimal rectum position: enema; prostate cancer spacer; fiber-/fat-free diet. Methods: A 70.2 Gray radiation divided into 26 hypo-fractions was administered to 115 patients with prostate cancer by VMAT referred to a single center in Italy. To empty the rectum, all patients were administered a fiber-/fat-free diet and those with Eating Disorders (ED) were also added with activated charcoal (2 tablets/day) and a macrogol-based medical device (2 sachets/day). During treatment, the volumetric amount of rectum in the target was measured by comparing control-CT with simulation-CT, and acute toxicity was also checked. Results: The rectum position during control-CT in diet-only patients (29) predicted toxicity recorded during treatment, while in the ED group rectum position was adherent to position during simulations. Rectal volume target > 0.25 cc receiving a dose > V70 caused acute G3 toxicity that attenuated or worsened with rectal displacement. Acute rectal toxicity occurred in 6/29 (20.68%) patients (1 G3, 5 G1) in the diet-only group, while only in 1/86 (1.16%) patients (G1) in the ED group. No chronic toxicity was recorded in either group. Conclusion: Prostate cancer patients treated with VMAT, diet, charcoal, and macrogol emptied the rectum optimally and reduced incidence and severity of acute rectal toxicity, also with benefit on late toxicity. #Prostaticneoplasm #Radiotherapy #Rectum #Radiationeffects #Diettherapy #Polyethyleneglycols #AcuteMedicine #AdolescentMedicine #Anatomy #Anesthesiology #Cardiology #ClinicalMedicine #DentalSciences #Dermatology #DrugandMedicalDevices #EmergencyMedicine #EnvironmentalHealth #FamilyMedicine #ForensicMedicine #Gastroenterology #GeneralMedicine #Genetics #Geriatrics #Gynecology #Haematology #HealthEconomics #HealthInformatics #HealthPolicy #HospitalMedicine #Immunology #InternalMedicine #MedicalEducation #MedicalEmergency #MedicalResearch #MolecularMedicine #Neurology #NuclearMedicine #ObstetricsOncology #OccupationalMedicine #Ophthalmology #Orthopaedics #Otolaryngology #Paediatrics #PainManagement #Pathology #Pharmacology #Physiology #PlasticSurgery #Psychiatry #PulmonaryMedicine #Pulmonology #Radiology #RehabilitationMedicine #Rheumatology #Urology #VeterinaryScience

https://lnkd.in/gCckw-hD Published article: Breast Cancer: The Road to a Personalized Prevention Author: Asia Grattagliano Abstract: Breast cancer is the most common type of cancer in women worldwide. It can be spread when cancer cells get into the blood or lymph system and then are carried to other parts of the body. As it is one of the leading causes of death among women, this study aims to identify the most relevant risk factors for breast cancer through several prevention methods for early detection. The social impact of breast cancer is so strong that the World Health Organization (WHO) has established 19 October as International Breast Cancer Day. The pink ribbon is the symbol of this important day worldwide. The objective is precisely to raise awareness among the population about the disease and promote access to timely and effective diagnoses, checks, and treatments. Good prevention should be carried out through behavior or lifestyle modifications (e.g., diet, physical activity, alcohol limitation, etc.). Although, certain risk factors cannot be modified (e.g., aging, family history). Screenings are a fundamental tool to deal with breast cancer, even if sometimes they are not enough as in the case of interval cancers or in cases of particularly ambiguous presentation. Worldwide organizations recommend screening by means of ultrasound, mammography, and magnetic resonance, with appropriate follow-up for an abnormal screening test. To avoid overdiagnosis and overtreatment that can lead to long-term complications and false negatives, these screening differs by recommended ages and frequency. Identification of women at risk for BRCA1 and BRCA2 mutations is also recommended with a referral for genetic testing and, in the presence of dubious lesions, a biopsy is needed. In order to fight this disease, is important to act on time, so, information is fundamental. First of all, the female population should be conscious of risk factors and of the importance of breast examinations from a young age, lastly, they should be aware of the possibility of joining programs of free screening. #Breastcancer #Prevention #Risks #Earlydetection #Screening #AcuteMedicine #AdolescentMedicine #Anatomy #Anesthesiology #Cardiology #ClinicalMedicine #DentalSciences #Dermatology #DrugandMedicalDevices #EmergencyMedicine #EnvironmentalHealth #FamilyMedicine #ForensicMedicine #Gastroenterology #GeneralMedicine #Genetics #Geriatrics #Gynecology #Haematology #HealthEconomics #HealthInformatics #HealthPolicy #HospitalMedicine #Immunology #InternalMedicine #MedicalEducation #MedicalEmergency #MedicalResearch #MolecularMedicine #Neurology #NuclearMedicine #ObstetricsOncology #OccupationalMedicine #Ophthalmology #Orthopaedics #Otolaryngology #Paediatrics #PainManagement #Pathology #Pharmacology #Physiology #PlasticSurgery #Psychiatry #PulmonaryMedicine #Pulmonology #Radiology #RehabilitationMedicine #Rheumatology #Urology #VeterinaryScience

https://lnkd.in/g7H5Hzrv Published article: Fibrin Contributes to an Improvement of an in vitro Wound Repair Model using Fibroblast-populated Collagen Lattices Author: Edgar Krötzsch Abstract: Incisional acute wounds of the skin are characterized by a rapid biomechanical response by stromal cell contraction that joins the wound lips through the fibrin cloth. In this work, we have performed an in vitro model using Fibroblast-Populated Collagen Lattices (FPCLs) that partially mimic that physiological process. Injured FPCLs under relaxed or stressed conditions were evaluated over time, and cross-sections of the lattices were stained with picrosirius red. Wounds filled with fibrin in relaxed FPCLs were closed earlier than controls, the fibrillar pattern of the collagen lattice was different between the wound and the edges of the lattice. On the other hand, stressed FPCLs did not close wounds, even those filled with fibrin, because the tension generated from the lattice borders maintained high tension towards the wound. Controls or fibrin-treated stressed FPCLs, showed high tension in the wound matrix, characterized by the high packing of collagen observed like yellow-red birefringent fibers when stained by picrosirius red. Despite wounds that remain open, fibrin-treated FPCLs exhibited less wound area than controls. With this work, we have demonstrated that FPCL models can be used to study wound closure, mainly when they are improved with other elements of the wound environment that allow us to analyze the biological process. #Woundhealing #Collagengels #Cloth #Stress #Incision #AcuteMedicine #AdolescentMedicine #Anatomy #Anesthesiology #Cardiology #ClinicalMedicine #DentalSciences #Dermatology #DrugandMedicalDevices #EmergencyMedicine #EnvironmentalHealth #FamilyMedicine #ForensicMedicine #Gastroenterology #GeneralMedicine #Genetics #Geriatrics #Gynecology #Haematology #HealthEconomics #HealthInformatics #HealthPolicy #HospitalMedicine #Immunology #InternalMedicine #MedicalEducation #MedicalEmergency #MedicalResearch #MolecularMedicine #Neurology #NuclearMedicine #ObstetricsOncology #OccupationalMedicine #Ophthalmology #Orthopaedics #Otolaryngology #Paediatrics #PainManagement #Pathology #Pharmacology #Physiology #PlasticSurgery #Psychiatry #PulmonaryMedicine #Pulmonology #Radiology #RehabilitationMedicine #Rheumatology #Urology #VeterinaryScience

https://lnkd.in/ghBNV_Sf Published article: A Rare Case of Recurrent Vulvovaginal Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP) Author: Sakshi Zawar Abstract: Smooth muscle tumours are the most common mesenchymal tumors of the vulva and vagina, yet their infrequency is demonstrated by the prevalence of published reports as individual cases or small case series. This article reports a case of a 42-year-old woman who presented with apparently recurrent vulvovaginal leiomyoma and a past history of surgical excisions. Histopathology revealed Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP). #Smoothmuscletumor #Vulva #Vagina #Leiomyoma #STUMP #Recurrence #AcuteMedicine #AdolescentMedicine #Anatomy #Anesthesiology #Cardiology #ClinicalMedicine #DentalSciences #Dermatology #DrugandMedicalDevices #EmergencyMedicine #EnvironmentalHealth #FamilyMedicine #ForensicMedicine #Gastroenterology #GeneralMedicine #Genetics #Geriatrics #Gynecology #Haematology #HealthEconomics #HealthInformatics #HealthPolicy #HospitalMedicine #Immunology #InternalMedicine #MedicalEducation #MedicalEmergency #MedicalResearch #MolecularMedicine #Neurology #NuclearMedicine #ObstetricsOncology #OccupationalMedicine #Ophthalmology #Orthopaedics #Otolaryngology #Paediatrics #PainManagement #Pathology #Pharmacology #Physiology #PlasticSurgery #Psychiatry #PulmonaryMedicine #Pulmonology #Radiology #RehabilitationMedicine #Rheumatology #Urology #VeterinaryScience