Singleron Biotechnologies

#CustomerPublicationWeekly Immune infiltration within the tumor microenvironment (#TME) is important for immune checkpoint blockade (#ICB) therapy to function. Mild photothermal therapy (PTT) is often combined with immunotherapy to enhance efficacy, likely by increasing immune cell infiltration and stimulating T-cell activity. Notably, the PTT also accelerates the release of tumor cell-derived exosomes (TEX) and upregulates PD-L1 expression on both tumor cells and TEX. A multi-stage drug delivery system is designed that concurrently delivers photosensitizers (reduced graphene oxide nanosheets, NRGO), anti-PD-L1 antibodies, and exosome inhibitors (sulfisoxazole). This local combination therapy remodels the immunosuppressive TME through exosome inhibition and enhanced immune cell infiltration, while also boosting T-cell activity to trigger systemic antitumor immunity- making it a promising approach to further improve immunotherapy efficacy. Singleron's GEXSCOPE Single Cell RNA Library Kit was used in this study to analyze TME. https://lnkd.in/e6-2VSQF

Happy New Year! 🎉 May this new year bring you success, happiness, and prosperity. Let's embrace the opportunities and challenges ahead with optimism and determination. Thank you for being a part of Singleron's journey!

#CustomerPublicationWeekly #Parkinson’s disease is characterised by nigrostriatal pathway dysfunction caused by the gradual loss of dopaminergic #neurons in the substantia nigra pars compacta of the midbrain. Researchers from Luxembourg Centre for Systems Biomedicine presented a nigrostriatal pathway model based on midbrain-striatum #assembloids with inducible #aging. These assembloids can develop characteristics of the nigrostriatal connectivity, with catecholamine release from the midbrain to the striatum and synapse formation between midbrain and striatal neurons, making them excellent tools to reveal the contribution of aging as well as nigrostriatal connectivity to the onset and progression of Parkinson’s disease. Singleron's GEXSCOPE Single Nucleus RNA Library Kit was used to analyze the cellular and molecular characteristics of the assembloids. https://lnkd.in/e5A7JkBv

Merry Christmas from the Microscopic World! With Simon, our SIngle cell Multi-Omics Navigator! This festive season, let's zoom into the wonder of life itself – the cell! Just like the twinkling lights on a Christmas tree, each cell in our body glows with the magic of life, keeping us vibrant and alive. Imagine each cell as a tiny, sparkling ornament: - **The nucleus**, like a festive bauble, holds the precious DNA, guiding our growth and health. - **Mitochondria** are the cheerful elves, working tirelessly to power every celebration within the cell. - **The endoplasmic reticulum** strings along like garlands, helping to transport proteins and lipids, much like gifts being passed around. - **Ribosomes** are the tiny, busy hands crafting all the molecular gifts needed for life's festivities. As we gather around our tables, let's remember that each of us is a complex celebration of cellular activity, a true miracle of nature. Wishing you a joyous holiday season filled with health, happiness, and the wonder of life's smallest celebrations! #MerryChristmas #CellularJoy #ScienceMeetsChristmas

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#CustomerPublicationWeekly Erectile dysfunction (#ED) significantly impacts male #fertility and quality of life. A recent PNAS paper (https://lnkd.in/d84iZmgg) describes an innovative magnetic soft microrobot comprising an ultrasoft hydrogel microsphere embedded with a magnetic nanoparticle chain for mesenchymal stromal cells (#MSCs) delivery which shows significantly enhanced MSC retention and survival. In both rat and beagle ED models, MSC-Rob treatment accelerated the repair of corpus cavernosum tissue and restored erectile function. #Single-cell RNA sequencing (scRNA-seq) revealed that MSC-Rob treatment facilitates nerve and blood vessel regeneration in the corpus cavernosum by increasing the presence of regenerative macrophages. Singleron's GEXSCOPE Products were used in this study.

Besides a great job everyday, here are some heartwarming initiatives our #Singleronies from all over the world have been taking to further help communities in need. At Singleron, we believe that every act of generosity, no matter how small, has the power to transform lives and inspire others to do the same. Here's to more initiatives like these in 2025!

Our first Made in Germany instruments were shipped all over the globe this year! 🇩🇪 Thanks to the meticulous work of our Engineering team, Jasmin Metze Mohamed Abdallah Bassiony Juan Antonio Monzón Vázquez now the Singleron #MatrixNeo and #PythoNJunior are both produced in our #Cologne headquarters. Congratulations to the team 👏 #SingleronBiotechnologies #SingleCell #MultiOmics #MadeinGermany

Choose your fighter 🎄🌟 for the best Christmas sweater competition! This #SecretSanta 🎅 we shared nice gifts, dressed on theme, and made sure to include our colleagues who couldn't be with us (if you thought Simon plushies couldn't get any more functional, you were mistaken)💡 Happy holidays everyone and enjoy your gifts #Singleronies ✨🎁

#CustomerPublicationWeekly Patients with gastric cancer peritoneal metastasis (#GCPM) have a poor #prognosis and respond poorly to conventional treatments. Recent development of immune checkpoint blockade (#ICB) has demonstrated favourable efficacy in the treatment of GCPM. A recent study published in the Gut magazine used #singlecellsequencing to analyse primary tumours, GCPMs and peripheral blood from patients with the aim to develop stratification strategy of of best responders. A stroma-myeloid crosstalk in GCPM is the major mediator of ICB resistance. Blocking the C3-C3AR1 axis disrupts the stroma-myeloid crosstalk and thereby significantly improves the benefits of ICB in in vivo models. The findings provide a comprehensive tumor microenvironment lanscape associated with ICB resistance in patients with GCPM and aid in the prioritisation of therapeutic candidates to potentiate immunotherapy. Singleron's GEXSCOPE Single Cell RNA Library Kit was used in this study. https://lnkd.in/ebmmu2P4