EMBL Grenoble a republié ceci
PROTEIN CRYSTALS MEASURED AT ROOM TEMPERATURE IN MICROSECONDS Studying macromolecular complexes at room temperature has always been challenging because of X-ray damage to the biological samples. Usually this is mitigated by collecting diffraction data at cryogenic conditions, but under these conditions functional dynamics are hindered. Scientists can now scan thousands of protein crystals at room temperature using X-ray microsecond pulses at the ESRF’s #serialcrystallography beamline, ID29. This capability is of utmost importance for time-resolved studies and #drugdiscovery research at physiological conditions. The results are published in Nature Portfolio 's Communications Chemistry. UNIQUE BEAMLINE The concept design of ID29, together with the technological advances, is a revolutionary step in macromolecular crystallography. The publication proves that the new ID29 bridges the standard structural biology beamlines and XFELs and establishes serial microsecond crystallography. “The results lead the way for the construction and commissioning of similar beamlines at other synchrotrons, currently undergoing or planning the upgrade of their accelerators”, says Daniele de Sanctis, scientist in charge of the beamline. The beamline is run jointly with the EMBL Grenoble, as part of the long-standing collaboration that the ESRF and EMBL have set up on the science campus in Grenoble. Shibom Basu Julien Orlans Sam Rose Gavin Ferguson Gergely Papp Jérémy Sinoir Alejandro A. Homs Puron Nicolas Coquelle Antonia Beteva ➡️https://lnkd.in/ex5Xb94B