MultiPark- Multidisciplinary neuroscience research at Lund University

🍴 MultiPark Lunch Seminar 🍴 In today’s lunch seminar, we delved into cutting-edge neuroscience, exploring the intricate relationships between neuropathologies and brain health. The session gave us a taste of new scientific insights from various neurodegenerative pathologies. 🧠  Sophie Mastenbroek dived into the effect of Lewy Body pathology on cognition Early-Onset Alzheimer’s disease. Did you know that co-morbid Lewy body pathology can shape the clinical progression of Alzheimer’s disease (AD)? While this is well-documented in typical AD cases, its role in early-onset Alzheimer’s disease (EOAD)—a rare form where symptoms appear before age 65—remains unclear. 🔍In her latest study, Sophie Mastenbroek from Oskar Hansson's lab explores the effects of Lewy body co-pathology on biomarkers and cognition in EOAD. 💪 Marie Sjögren, PhD working in the group lead by Maria Björkqvist spoke about muscle atrophy in Huntington’s disease and the protective effect of ghrelin. Skeletal muscle wasting is a common challenge for Huntington's disease (HD) patients, significantly affecting their quality of life. Satellite cells are progenitors of muscle tissue and important for repair. In her latest research she dives into: 🔍 The role of satellite cells in HD. 🔍 How the HTT CAG repeat expansion impacts these cells. 🔍 The protective effects of ghrelin, a gut hormone known to regulate energy metabolism and counteract catabolism in HD models. 🧠 Amanda Annettesdotter, PhD student with Laura Wisse presented new Insights on Amygdala degeneration in neuropathologies. The amygdala, an early hotspot for neuropathologies, is strongly linked to volume loss caused by conditions like tau and TDP-43. Did you know that early accumulation of different neuropathologies often target different subregions of the amygdala? In her latest study, Amanda analyzed postmortem data from individuals with and without neurodegenerative diseases to explore: 🔍 The connections between four key pathologies (tau, amyloid-β, TDP-43, and α-synuclein) and amygdala volume loss. 🔍 Which subregions of the amygdala are most affected by these pathologies. Thank you to everyone who joined and contributed to the engaging discussions! 🧠✨ #AlzheimersDisease #HuntingtonsDisease #LewyBody #biomarkers #tau #TDP43 #SatelliteCells #neuroscience #Dementia #Ghrenlin #Amygdala

Welcome to our Christmas-themed OPEN DAY next week! Lund Stem Cell Center, Lund University Medicinska fakulteten, Lunds universitet, MultiPark- Multidisciplinary neuroscience research at Lund University

A new way to treat neurological diseases such as Alzheimer’s, schizophrenia, and epilepsy could emerge from something that started as a failed experiment. Daniella Rylander Ottosson, from Lund University, entered the field of research surrounding a cell called Parvalbumin in this way. This little cell can be likened to a conductor – who makes sure that everyone is coordinated – that the flow of information takes place at the right pace. If the Parvalbumin cells are damaged or dead, the timing becomes inaccurate, and the signals fall out of sync. There is much to suggest that this could be one of the causes of diseases such as epilepsy, schizophrenia, and Alzheimer’s. Read more about Daniella Rylander Ottosson's research https://lnkd.in/dnKmhH9m #research #science #medicine #Alzheimers #Epilepsy #schizofrenia Lund University Daniella Rylander Ottosson, PhD

🌟 Lund Stem Cell Center is at the ATMP Sweden Conference in Malmö today and tomorrow! Visit our booth at the Clarion Hotel & Congress Malmö Live to learn more about our research in advanced therapy medicinal products (#ATMPs). Our researchers will also be presenting their work, beginning with: 💡 Prof. Anna Falk who helped kick off the conference with a presentation emphasizing the vital link between #healthcare, #academia, and #industry & #innovation to bring ATMPs to patients, and will also chair the session on "Human Pluripotent Stem Cell-Derived ATMPs" starting at 2:20 PM. 💡 Keynote speaker, Prof. Malin Parmar will present on "FIH hESC-derived dopaminergic neuron progenitors for Parkinson’s disease" at 1:40 PM today. We look forward to connecting with you! Drop by our booth to discuss the latest in ATMP research, pick up your copy of our 2024 ATMP Pipeline Report, and say hello 👋 #ATMP #CancerResearch #GeneTherapy #StemCellResearch #Parkinsons #Innovation #LundStemCellCenter #ATMPSweden

Genetic risk factors for diseases can vary between populations. The T369M variant in the GBA1 gene, which encodes a lysosomal membrane protein, has been linked to an 80% increased risk of Parkinson's disease. However, recent findings suggest this association might not apply to the Swedish population. Maria Swanberg and collaborators investigated this further by studying the T369M variant in a large Swedish Parkinson's cohort. Their results confirm earlier observations: this genetic variant does not appear to increase the risk of Parkinson’s disease in the Swedish population. Lead author: Kajsa Atterling Brolin, PhD Link to article 👉 https://lnkd.in/d_kP-yZy Co-authors: David Bäckström, Joel Wallenius, Ziv Gan-Or, Andreas Puschmann , Oskar Hansson Journal: Parkinsonism Related Disorders Are you intrigued by genes and Parkinson's disease? Then tune in to Maria's MultiPark podcast episode to hear about her journey as a scientist and her research 🎧 https://lnkd.in/di7yYK6v #Parkinson #genetics #GBA1 #neurodegeneration #neuroscience #LundUniversity

Interested in registering for the 7T symposium in Lund? See below. Professor Niklas Marklund is presenting his research.

Read the news article titled: Using light to create bioelectronics inside the body by Lunds universitet, where they highlight the important work from Roger Olsson and his team 👉 https://lnkd.in/di8fwVJm

Two Wednesdays each month, MultiPark hosts a lunch seminar. At the seminar, MultiPark's brilliant young scientists present their resent findings. Last weeks seminar offered fascinating talks from Noëlle Warmenhoven and Alina Blusch. Noëlle Warmenhoven, from the Oskar Hansson group, is tackling an important question within Alzheimer's disease biomarker research: which p-tau217 biomarker test performs best? Phosphorylation at tau position 217 (p-tau217) has emerged as a leading biomarker for Alzheimer’s detection, with multiple assays developed due to its huge potential. But until now, no one knew which test truly stands out. In her latest study, Noëlle conducts a head-to-head comparison of the key p-tau217 assays—paving the way for better diagnostics in Alzheimer’s disease! Read about her findings here 👉 https://lnkd.in/dA9a-_Nt Alina Blusch, a postdoc with Maria Björkqvist, presented her work on inflammation in the meninges in Huntington's disease. While it is know that the immune system and inflammation impact HD, the meninges—once thought to be just a protective barrier—are now emerging as key players in brain health and immune responses. Using a mouse model and flow cytometry, Alina is investigating how meningeal immune cells change in HD. This could open up new ways of understanding HD’s complex pathology and lead to fresh perspectives on brain-immune interactions! #neuroscience #seminar #biomarkers #Alzheimers #Huntington #meninges #pTau217 #LundUniversity Frame created by ChatGTP.

Read about MultiPark's special interest group: cellular reprogramming, where Henrik Ahlenius, the convening researcher, explains the purpose of the special interest group. Follow the link if you are interested in more special interest groups at MultiPark: https://lnkd.in/dCS9aVvH

Don't miss the defence of Jonas Fritze, a PhD student in Henrik Ahlenius' group Learn more about neurogenesis (the formation of new neurons) and how it is affected by aging. Time: 26th of November, 13:00 Place: Segerfalksalen, BMC A10 Lund 🚩Thesis abstract: Neurogenesis continues throughout life in two key regions, the subventricular zone (SVZ) and dentate gyrus (DG), but declines with age alongside increased chronic inflammation and microglial activation. These neurogenic niches differ in their susceptibility to systemic changes, with the SVZ located near cerebrospinal fluid and the DG influenced by local neural activity. We found that immune changes, including altered expression of microglia-specific Cx3cr1, leukocyte-specific Cxcr5, systemic cytokine IL-6, and local Cxcl12, specifically impact SVZ intermediate progenitors during aging, leading to distinct effects on neurogenesis in the SVZ compared to the DG. In addition, we identified a subset of SVZ neuroblasts that acquire an immune related transcriptional profile during aging, indicating a potential role in how immune changes influence neurogenesis. Our findings highlight inflammation as a central driver of age-related neurogenic decline and emphasize the need for niche- and age-specific therapeutic strategies that target immune cells or signalling pathways. Read more about the disputation here 👉 https://lnkd.in/dRFq8XSQ #ageing #neurogenesis #microglia #inflammation #brain #neuroscience