Bioengineering MDPI’s Post

🧬 Ready to take organoid research to the next level? Dive into the intricate 3D vascular structures captured through advanced microscopy! 🌱✨This video highlights how our #OrganoidReagentKit enables precise analysis and development of complex tissue models. 🚀 With our innovative solutions, explore how 3D cell culture and organoid technology are transforming biomedical research! 🌐🔬 #OrganoidResearch #3DCellCulture #OrganoidReagentKit #VascularOrganoids #DrugDiscovery #BiotechInnovation #NestBiotech #RegenerativeMedicine #PharmaceuticalResearch

Can we treat #LungDisease with tissue engineering? ♻️ In today's #JournalClub paper, researchers from the University of Cambridge and Institute of Lung Health and Immunity developed a #Biomimetic lung scaffold using our IMR-90 #CellLine — learn more at MDPI: https://okt.to/6Z2aRx

A comprehensive kit driving transformation of biomedical research.

One step closer to long-term vascularization of 3D in vitro models? 📢 🎉 Our new paper is out in Advanced Functional Materials (Wiley) identifying promising conditions in PEG-based, glycosaminoglycan (GAG)-containing hydrogels: https://lnkd.in/eEaVRHxP 1. 💡 We found that the overall concentration as well as sulfation pattern of the GAG heparin are crucial in instructing 3D microvascular network formation and long-term stability.   2. 🔎 Formed dense and stable microvascular networks further supported mesenchymal stromal cell proliferation, ECM deposition and overall matrix stiffening. 3. 📈 Our systematic study gives great insights for future fine-tuning of stable long-term vascularization in other 3D tissue- and disease models. 👏 Congrats to Yanuar Dwi Putra Limasale and the team Marten Samulowitz, Passant Atallah, PhD, Jana Sievers-Liebschner, Nicholas Dennison, Uwe Freudenberg, Jens Friedrichs and Carsten Werner 🤝 Further support by our colleagues at Leibniz-Institut für Polymerforschung Dresden and funding by Deutsche Forschungsgemeinschaft (DFG) - German Research Foundation is highly appreciated #TissueEngineering #RegenerativeMedicine #Hydrogel

Developing and characterising nanofibrous scaffolds with extracellular vesicles loaded with curcumin: in their latest article, Adrienn Nochta-Kazsoki PharmD, PhD, Dr. Zelkó Romána at Semmelweis University incorporated large curcumin-loaded EVs into fast-dissolving poly(vinyl alcohol) nanofibers through electrospinning, using aqueous PVA solutions. Confocal laser scanning microscopy confirmed the presence of curcumin-loaded lEVs within the nanofibers. https://lnkd.in/gCqubadN Release studies showed high drug concentrations in lEV-containing nanofibers, underscoring the potential of EV-loaded nanofibrous systems for enhanced therapeutic applications and improved patient outcomes. An article co-authored by Krisztina Németh, TAMÁS VISNOVITZ, Dorina Lenzinger and Edit Buzás #extracellularvesicles #exosomes #drugloading #bioengineering #Vesiculab

🎉We are excited to share that our colleague, Dr. Aleksandar Janev, has been awarded the Best Poster Award at the IPLASS and CTESS Joint International Conference: "New Horizons in Cell and Tissue Engineering and Perinatal Derivatives", held in Izola, Slovenia from September 19th to 20th 🎉. Dr. Janev’s poster, titled "Identification of potential therapeutic targets by transcriptional profiling of normal and cancerous bladder urothelial cells treated with human amniotic membrane homogenate," provided insights into the transcriptomic responses of normal and cancerous bladder urothelial cells to treatment with hAM homogenate. #AmnioticMembrane #PerinatalDerivatives #Research #NovelTherapeutics #IPLASS

#cbt #academicpublishing Spatial analysis of the #osteoarthritis microenvironment: techniques, insights, and applications. Authors: Fan Xiwei, Antonia Sun, PhD Sun, Reuben Young Young (not pictured), Louis Ong, Ross Crawford and Indira Prasadam, in collaboration with (not pictured) Isaac Afaraand and Brett Hamilton. Published in Springer Nature Group - Bone Research. Read more: https://lnkd.in/e_aqmpM7 Osteoarthritis (OA) is a debilitating degenerative disease affecting multiple joint tissues, including cartilage, bone, synovium, and adipose tissues. It presents diverse clinical phenotypes and distinct molecular endotypes, including inflammatory, metabolic, mechanical, genetic, and synovial variants. Consequently, innovative technologies are needed to support the development of effective diagnostic and precision therapeutic approaches. Traditional analysis of bulk OA tissue extracts has limitations due to technical constraints, causing challenges in the differentiation between various physiological and pathological phenotypes in joint tissues. This issue has led to standardization difficulties and hindered the success of clinical trials. This review summarizes the recent advancements in the molecular imaging modalities and methodologies for in-depth spatial analysis. It explores their applications, challenges, and potential opportunities in the field of OA. Additionally, this review provides a perspective on the potential research directions for these contemporary approaches that can meet the requirements of clinical diagnoses and the establishment of therapeutic targets for OA. More publications from our Centre: https://lnkd.in/gwVZR7eR #medicalmanufacturing #biomedical #medicalengineering #medicalinnovation #medicalresearch #medical #roboticsurgery #3dbioprinting #tissueengineering #biomechanics #collaboration #qut #QUTResearch

My colleague, Margaret (Mache) Cruz, presented our research on "Facile Extraction of α2 Beta Casein Milk-Derived Extracellular Vesicles and Their Impact on C2C12 Cell Migration" at BMES. This research highlights how milk-derived EVs can enhance cell migration in C2C12 murine myoblasts, showcasing their potential in therapeutic applications for tissue healing. We are proud of our team's dedication to advancing biomedical engineering. #BiomedicalEngineering #ResearchInnovation #ExtracellularVesicles #TissueEngineering #CMUEngineering

Alliance for Regenerative Medicine published this whitepaper providing examples of the scientific advances in tissue engineering as well as insights from developers and regulators on chemistry, manufacturing, and controls considerations for the industry. Thanx for sharing Lindsay Gasch, PharmD, BCPS, BCACP!

🌟 Imagine a future where cartilage damage can be healed in just hours—it's now possible with 'dancing molecules'! 🌟 Northwestern University researchers have developed a new therapy using "dancing molecules" to heal cartilage damage. This innovative method mimics the natural signaling of the TGF-β1 protein with synthetic nanofibers, quickly activating the genes needed for cartilage regeneration in just four hours! By increasing the molecular motion within these nanofibers, the treatment effectively triggers cartilage growth and repair. Key Highlights: 🔹 Potential game-changer for osteoarthritis treatment, benefiting nearly 530 million people worldwide. 🔹 Proven effectiveness in both cartilage cells and spinal cord repair, showing a universal healing capability. 🔹 Early success in human cells, with animal studies and clinical trials coming soon. This discovery offers new, non-invasive solutions for joint and tissue repair, marking a significant advancement in the field of regenerative medicine! #innovation #innovationforall ##RegenerativeMedicine #Nanotechnology #Healthcare #Osteoarthritis Link: https://lnkd.in/gcnqygxN Post Credit - Dr. Himanshu Sharma (Ph.D.)