Microbial Signals to Distant Organs and External Influences - What you should know!
#Mysummary
The gut microbiota can send various signals to distant organs in the body and can be influenced by several factors:
1. Short-chain fatty acids (SCFAs): SCFAs like butyrate, propionate, and acetate are produced when gut bacteria ferment dietary fiber. These SCFAs enter the bloodstream and can have systemic effects. For example, butyrate has been found to cross the blood-brain barrier and influence gene expression in the brain.
2. Bile acids: Gut bacteria play an important role in bile acid metabolism by deconjugating and transforming primary bile acids into secondary bile acids. These bile acids can activate receptors like TGR5 and FXR found in many tissues, which influences lipid and glucose metabolism in the liver and immune responses.
My favorite:
3. Tryptophan metabolites: Gut bacteria produce metabolites like indole, indole propionic acid, and tryptamine from amino acids like tryptophan. These metabolites can cross the blood-brain barrier and influence the nervous system by binding to receptors. They may influence brain function and behavior.
4. Lipopolysaccharide (LPS): LPS is a component of Gram-negative bacterial cell walls. When there is imbalance of gut bacteria, LPS can enter the bloodstream (metabolic endotoxemia) and trigger low-grade chronic inflammation systemically by binding to Toll-like receptors. This has been linked to insulin resistance, obesity, and diabetes.
#Mythoughts
You may think it will be difficult for you to directly influence the signals, but you can definitely influence the influencers!
HAPPY to hear your THOUGHTS and Stay POSITIVE!
#Myinspiration
"Your time is limited, so don't waste it living someone else's life. Don't be trapped by dogma – which is living with the results of other people's thinking. Don't let the noise of others' opinions drown out your own inner voice. And most important, have the courage to follow your heart and intuition." - Steve Jobs
You can read more here on the specific case of cancer: https://lnkd.in/e9UU9M6D
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CEO, Director, Advisor, Consultant
2moEndless benefits from Omega3's. thanks for sharing