Congratulations to the entire team! By the way: Jonas Motter is a testimonial for our 'Berlin Doctoral Programs' platform, which provides a great overview of over 100 PhD programs available in Berlin 👉 https://lnkd.in/dAheMXKE
✨ Our paper is published in Green Chemistry (Royal Society of Chemistry)! We present a sustainable biocatalytic process for the one-pot synthesis of Ribose-1-phosphate (Rip1P), a key substrate for the synthesis of new nucleoside-based drugs (e.g., antibiotics). However, its use in preparative synthesis has been hampered by low yields and low selectivity during conventional methods (also reflected in the high price). By coupling a guanine deaminase to the nucleoside phosphorylase-catalysed guanosine (Guo) cleavage, the reaction shifted towards almost complete Guo cleavage. Our cascade approach reduced the need for toxic reagents and purification steps inherent to previous methods, reducing the environmental burden of the route. Big thanks to all the authors: Sarah Westarp, Jonas Barsig, Christina Betz, Amin Dagane, Felix Kaspar, Lena Neumair, Sebastian Kemper, Peter Neubauer, and Anke Kurreck 📄 Please have a read (it is open access): https://lnkd.in/e6XC7wXJ Chair of Bioprocess Engineering-TU Berlin Einstein Foundation Berlin UniSysCat - Cluster of Excellence #biocatalysis #GreenChemistry #nucleosides
