Male Breast Cancer Global Alliance’s Post

📃Scientific paper: Unraveling the microRNAs, key players in folliculogenesis and ovarian diseases Abstract: Background Folliculogenesis is an intricate process that involves the development and maturation of ovarian follicles in females. During folliculogenesis, multiple factors including hormones, growth factors, and signaling pathways regulate the growth and maturation of follicles. In recent years, microRNA, short non-coding RNA molecules, has gained attention due to its roles in the physiology and pathophysiology of various diseases in humans. It is known to have an important part in ovarian health and illness and its functions extend to several cellular processes. Main body In this overview, we look at the importance of microRNAs in ovarian illnesses and how they function during follicle growth in the ovaries. Short RNA molecules (22 nucleotides) called microRNAs may influence several mRNA targets in different biological processes. The expression patterns of these small non-coding RNAs undergo dynamic changes during the several phases of follicular development; they play a function in post-transcriptional gene regulation. Follicle development, follicular atresia (regression of the follicles), and ovulation are all intricately regulated by the dynamic expression of distinct miRNAs throughout the various phases of folliculogenesis. The role of microRNAs (miRNAs), which are known to regulate gene expression, has recently come to light as crucial in the development and advancement of a number of ovarian diseases. Abnormalities of the human ovary, such as ovarian cancer,... Continued on ES/IODE ➡️ https://etcse.fr/uLQlJ ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

Uncovering Mutations in Your DNA: The Key to Personalized Medicine! Have you ever wondered what secrets lie within your DNA? 🔬🔍 With advanced genetic testing, we can now uncover mutations that might influence your health. Whether it's understanding your risk for certain diseases or finding the best treatments just for you, your DNA holds the answers. 🧬 By exploring your genetic blueprint, you can: ✅ Identify potential health risks early ✅ Personalize your treatment plans ✅ Make informed decisions about your health To Learn More: https://lnkd.in/gJmjU4nv To know More About Our Range of Services: Website: [www.bioserve.in] Contact Form: [https://lnkd.in/duuytdzr] To Call: +91 912 122 9283 Email: bioserve.india@reprocell.com #BiomarkerTesting #CancerBiomarkers #CancerDiagnostics #PrecisionMedicine #OncologyResearch #CancerScreening #EarlyDetection #MolecularDiagnostics #CancerCare #PersonalizedMedicine #BiomarkerResearch #CancerTreatment #bioserve

Snapshot of #cancerimmunotherapy with #oncolyticviruses. Oncolytic viruses (OVs) preferentially infect and kill cancer cells without harming normal cells. OVs can revert cancer-associated immune suppression and initiate clinically meaningful antitumor immune responses. OVs and their resultant immunological events can act at both primary and metastatic sites. Thus, OVs can be exploited for cancer gene therapies and immunotherapies alone or in combination with other interventions, including immune checkpoint blockade. Find out how YXgene can help your research: https://lnkd.in/ek-92bbg #immunology #immunotherapy #cancertherapy #genetherapy #celltherapy Image from https://lnkd.in/eaqvVdaT

#Bcells "Get under the Skin" of #Cutaneous #Tcell #Lymphoma | Disease Atlas shows a B cell-rich #tumormicroenvironment supporting malignant #TH2 cells | Major Advance from Ruoyan Li et al online at Nature #Immunology 👏 | “Here*, Li et al identified a colocalization of CTCL cells with antigen-presenting dendritic cells and B cell subsets that may support CTCL survival through activation signals. Interestingly, they found a correlation between B cell abundance and survival outcome in advanced CTCL, and an interaction between malignant TH2 cells and B cells — ultimately proposing new therapies to deplete or block B cell functionality.” Iannis Aifantis *https://lnkd.in/eTENUk-f Celentyx Ltd #immunooncology www.celentyx.com Professor Nicholas Barnes PhD, FBPhS Omar Qureshi Catherine Brady SUMMARY FIGURE | The data suggest that malignant T cells coopt TH2-like gene programs that are supported by a TH2-permissive (TME). Formation of tertiary lymphoid-like structures (TLSs) fosters interactions between tumor cells, B cells and stromal cells and correlates with disease progression | Taken from accompanying 'Research Briefing' https://lnkd.in/e7k4mKYj |

A new study has found an interesting link between gene mutations in blood #cancer and #arthritis. The publication explains how specific gene mutations in blood cancer can impact autoimmune diseases such as seronegative RA. The study suggests that effective metabolic therapies in treating blood cancer may help arthritis patients.   → Conclusion: • IDH mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis. • High levels of 2-hydroxyglutarate mediate IDH-associated activation of innate immune response.   → Lih En Hong, Mihir D Wechalekar, and Devendra Hiwase led the research team at the Royal Adelaide Hospital in Australia for this study.    → Publication: Hong, Lih En, et al. "IDH Mutant Myeloid Neoplasms are Associated with Seronegative Rheumatoid Arthritis and Innate Immune Activation." Blood (2024).   📖 Read on…https://lnkd.in/egV5am-P   #Inflammation #Immunotherapy #DrugDevelopment

[ #metastasis #review ] Decoding the interplay between genetic and non-genetic drivers of metastasis This review mainly talks about: - A framework for non-genetic variation and somatic evolution in cancer - Genetic drivers of metastasis - Phenotypic plasticity as an important source of metastatic traits - The first phase of metastasis: dissemination - Dormancy and outbreak - Immune evasion - Metabolic plasticity - Adaptation to therapy and other macroenvironmental cues https://lnkd.in/dAuCyYpf

Methylation genes that are linked to Breast Cancer Methylation is a key biochemical process that helps regulate gene expression, detoxification, and hormone metabolism. When methylation is imbalanced, it can disrupt these critical metabolic functions, leading to a potential increase in the risk of chronic conditions like breast cancer. Here are 2 important methylation genes linked to breast cancer:  1. MTHFR: The MTHFR gene is key for proper methylation. When it's not functioning well, genes that protect against cancer can be silenced, increasing breast cancer risk. 2. Estrogen and COMT: The COMT gene helps break down estrogen. Poor methylation of COMT can lead to harmful estrogen build-up, raising breast cancer risk. With estrogen metabolism tests like the Dutch(R) test, the role of these genes can be tracked looking at the levels of methylated metabolites to assess risks. With advanced programs like our Willbe Female Hormone Optimisation Program, testing of these key methylation genes (and others) are included so a deeper understanding of estrogen pathways, detoxification and inflammation can be assessed.  If you want to understand more about your genetics and impacts on your health, including breast cancer, the team at Willbe are here to chat with you. #willbe #methylation #estrogen #hormonehealth #brca1 #genetics #epigenetics #biohacking #healthspan #breastcancer #breastcancerawareness #longevity #menopausecoach #dutchtest #breasties

Unlocking Genetic Clues in Lymphedema Research 🚨 Recent discoveries in the FLT4 gene have brought us closer to understanding hereditary lymphedema, particularly Milroy disease. A compelling study has revealed that mutations in VEGFR3 (FLT4) result in lymphatic vessel dysfunction, leading to congenital lymphedema. These findings are a step forward for targeted therapies and may pave the way for future gene-editing treatments. #Genetics #HealthcareInnovation #Lymphedema #FLT4 #GenomicMedicine #MedicalResearch

Space Crystals and the Search for a Cancer Cure: Using Microgravity to Improve Protein Crystallization "Proteins are complex molecules that drive cellular function to maintain our health. They are made of hundreds, or thousands, of amino acids arranged in a particular sequence, which determines a protein’s 3D structure and function. Genes provide cells with instructions to produce specific proteins for different purposes. However, when a gene mutates, the instructions it sends are not quite right. When cells produce proteins that do not function correctly, it can lead to disease." READ MORE: https://loom.ly/1XnZR_U

The incidence and prevalence of SLE in North America are 23.2 and 241 per 100,000 people per year respectively while the incidence in Africa is 0.3 per 100,000 people per year. The study aims to predict the autoimmune response of killer T-cells in a patient suffering from Systemic Lupus Erythematosus by searching for variations in genes regulating the activities of Killer T cells. An approximate matching algorithm applying the Boyer-Moore Algorithm for the matching algorithm. Nucleotide sequences of each of the genes liked to Killer T-cells in reference human genome to DNA sequences of SLE patients. The threshold on all single nucleotide polymorphisms (SNPs) is set to 10% of the nucleotide sequence length of the gene. For 50% of susceptibility genes with no match the patient is susceptible. Sixteen (16) patients show that they are all guaranteed to manifest autoimmune Killer T-cells. The algorithm can predict the response of killer T-cells and improve the early detection and treatment of SLE patients. A similar approach can be used for genetically linked diseases like cancer.  by Wai Lok Woo, Ephraim Nwoye, Fidelis P Obinna, Nwosu O I, Balogun O Jessy, Raid Rafi Al-Nima #snp #tcells #autoimmunedisease #computationalbiology #genome #genetics https://lnkd.in/gYQ_8FNP